Results 251 to 260 of about 670,787 (298)
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Nature Biotechnology, 2015
The in vitro potency of antibody-drug conjugates (ADCs) increases with the drug-to-antibody ratio (DAR); however, ADC plasma clearance also increases with DAR, reducing exposure and in vivo efficacy. Here we show that accelerated clearance arises from ADC hydrophobicity, which can be modulated through drug-linker design.
Robert P, Lyon +9 more
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The in vitro potency of antibody-drug conjugates (ADCs) increases with the drug-to-antibody ratio (DAR); however, ADC plasma clearance also increases with DAR, reducing exposure and in vivo efficacy. Here we show that accelerated clearance arises from ADC hydrophobicity, which can be modulated through drug-linker design.
Robert P, Lyon +9 more
openaire +4 more sources
Diffusion-Precipitin Index to Antibody Avidity
Science, 1961Antigen, diffusing into converging edges of an antibody depot, inhibits the precipitation unless the reaction is completed before an inhibiting antigen excess is established. Since the rate of the increase of antigen concentration depends on the size of the angle, relative avidities of similar preparations of antibody may be estimated from the angle ...
R K, JENNINGS, M A, KAPLAN
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Ki-67 Antibody Labeling Index in Colorectal Carcinoma
Journal of Clinical Gastroenterology, 1992Ki-67 labeling index of 58 colorectal carcinomas and 10 normal colonic mucosa samples was determined by the use of an immunohistochemical staining technique. The Ki-67 labeling index in colorectal carcinomas ranged from 15.7 to 63.6% (mean +/- SD of 38.5 +/- 10.5) and was significantly higher than the index for normal colon mucosa (mean +/- SD of 14.1 +
H, Suzuki, K, Matsumoto, M, Terabe
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Journal of Infectious Diseases, 1987
Naturally occurring antibodies reactive with the phosphocholine (PC) determinant of pneumococcal teichoic acids may be useful for evaluating the potential of patients to make antibodies to polysaccharides. Antibodies to PC are present in most adults under the age of 60 years, are absent in very young children, and are present at low levels in Wiscott ...
D E, Briles +7 more
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Naturally occurring antibodies reactive with the phosphocholine (PC) determinant of pneumococcal teichoic acids may be useful for evaluating the potential of patients to make antibodies to polysaccharides. Antibodies to PC are present in most adults under the age of 60 years, are absent in very young children, and are present at low levels in Wiscott ...
D E, Briles +7 more
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American Journal of Veterinary Research, 2008
Abstract Objective—To investigate the use of a specific antibody index (AI) that relates Sarcocystis neurona–specific IgG quotient (QSN) to total IgG quotient (QIgG) for the detection of the anti–S neurona antibody fraction of CNS origin in CSF samples obtained from horses after intragastric administration of S neurona sporocysts.
Katherine A, Heskett, Robert J, Mackay
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Abstract Objective—To investigate the use of a specific antibody index (AI) that relates Sarcocystis neurona–specific IgG quotient (QSN) to total IgG quotient (QIgG) for the detection of the anti–S neurona antibody fraction of CNS origin in CSF samples obtained from horses after intragastric administration of S neurona sporocysts.
Katherine A, Heskett, Robert J, Mackay
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Therapeutic Index (TI) of Antibody-drug conjugates
2023Therapeutic Index (TI) of Antibody-drug conjugates.
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Antibody efficacy as a keen index to evaluate influenza vaccine effectiveness
Vaccine, 1997The efficacy of the influenza vaccine is often understimated, due to the dilution of the outcome by noninfluenzal illnesses. We thus explored the methodology to evaluate the effect of the inactivated influenza vaccine under the following strict conditions: an assessment of the effectiveness on clinical illness among healthy adults in a small-scale ...
Y, Hirota +6 more
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Terminal latency index in neuropathy with antibodies against myelin‐associated glycoproteins
Muscle & Nerve, 2007AbstractNeuropathy with antibodies against myelin‐associated glycoproteins (MAG/SGPG‐N) and hereditary sensorimotor neuropathy type 1 (HMSN1) are characterized by chronic demyelination with little conduction block. Electrodiagnostic studies suggest that in HMSN1 conduction slowing occurs uniformly along the nerve, whereas in MAG/SGPG‐N it is ...
Vitalie D, Lupu +5 more
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