Results 241 to 250 of about 6,557,782 (278)

Ki-67 Antibody Labeling Index in Colorectal Carcinoma

Journal of Clinical Gastroenterology, 1992
Ki-67 labeling index of 58 colorectal carcinomas and 10 normal colonic mucosa samples was determined by the use of an immunohistochemical staining technique. The Ki-67 labeling index in colorectal carcinomas ranged from 15.7 to 63.6% (mean +/- SD of 38.5 +/- 10.5) and was significantly higher than the index for normal colon mucosa (mean +/- SD of 14.1 +
H, Suzuki, K, Matsumoto, M, Terabe
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Anti-JC Virus (JCV) Antibody Index Differentiates Risk of Progressive Multifocal Leukoencephalopathy (PML) in Natalizumab-Treated Multiple Sclerosis (MS) Patients with No Prior Immunosuppressant (IS) Use: An Updated Analysis (P4.031)

Neurology, 2015
OBJECTIVE: To evaluate associations of anti-JCV antibody index with PML risk in natalizumab-treated MS patients without prior IS use (no-IS patients), using a recent data set.
G. Kuesters, T. Plavina, Sophia Lee, D. Campagnolo, S. Richman, S. Belachew, M. Subramanyam   +6 more
semanticscholar   +1 more source

Antibody efficacy as a keen index to evaluate influenza vaccine effectiveness

Vaccine, 1997
The efficacy of the influenza vaccine is often understimated, due to the dilution of the outcome by noninfluenzal illnesses. We thus explored the methodology to evaluate the effect of the inactivated influenza vaccine under the following strict conditions: an assessment of the effectiveness on clinical illness among healthy adults in a small-scale ...
Y, Hirota, M, Kaji, S, Ide, J, Kajiwara, K, Kataoka, S, Goto, T, Oka   +6 more
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Terminal latency index in neuropathy with antibodies against myelin‐associated glycoproteins

Muscle & Nerve, 2007
AbstractNeuropathy with antibodies against myelin‐associated glycoproteins (MAG/SGPG‐N) and hereditary sensorimotor neuropathy type 1 (HMSN1) are characterized by chronic demyelination with little conduction block. Electrodiagnostic studies suggest that in HMSN1 conduction slowing occurs uniformly along the nerve, whereas in MAG/SGPG‐N it is ...
Vitalie D, Lupu, Carlos A, Mora, Jim, Dambrosia, Jacob, Meer, Marinos, Dalakas, Mary Kay, Floeter   +5 more
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Heart-Reactive Antibody: An Index of Cardiac Rejection in Human Heart Transplantation

Circulation, 1970
Indirect immunofluorescent techniques used for detection of heart-reactive antibody have been used in both human and experimental cardiac transplantation. Definite evidence is presented which demonstrates the presence of circulating heart-reactive antibody preceding clinical or laboratory evidence of cardiac rejection.
R J, Ellis, C W, Lillehei, V A, Fischetti, J B, Zabriskie   +3 more
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Terminal latency index in polyneuropathy with IgM paraproteinemia and anti‐MAG antibody

Muscle & Nerve, 2001
AbstractCriteria for the diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) are met by the polyneuropathy associated with immunoglobulin M (IgM) paraproteinemia and anti‐myelin–associated glycoprotein (MAG) antibody (MAG‐CIDP). However, MAG‐CIDP differs from other types of CIDP, mainly in its poorer response to treatment. The utility
D, Cocito, G, Isoardo, P, Ciaramitaro, G, Migliaretti, A, Pipieri, P, Barbero, A, Cucci, L, Durelli   +7 more
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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Nature Biotechnology, 2008
Antibody-drug conjugates enhance the antitumor effects of antibodies and reduce adverse systemic effects of potent cytotoxic drugs. However, conventional drug conjugation strategies yield heterogenous conjugates with relatively narrow therapeutic index (maximum tolerated dose/curative dose). Using leads from our previously described phage display-based
Jagath R, Junutula, Helga, Raab, Suzanna, Clark, Sunil, Bhakta, Douglas D, Leipold, Sylvia, Weir, Yvonne, Chen, Michelle, Simpson, Siao Ping, Tsai, Mark S, Dennis, Yanmei, Lu, Y Gloria, Meng, Carl, Ng, Jihong, Yang, Chien C, Lee, Eileen, Duenas, Jeffrey, Gorrell, Viswanatham, Katta, Amy, Kim, Kevin, McDorman, Kelly, Flagella, Rayna, Venook, Sarajane, Ross, Susan D, Spencer, Wai, Lee Wong, Henry B, Lowman, Richard, Vandlen, Mark X, Sliwkowski, Richard H, Scheller, Paul, Polakis, William, Mallet   +30 more
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Developability Index: A Rapid In Silico Tool for the Screening of Antibody Aggregation Propensity

Journal of Pharmaceutical Sciences, 2012
Determining the aggregation propensity of protein-based biotherapeutics is an important step in the drug development process. Typically, a great deal of data collected over a large period of time is needed to estimate the aggregation propensity of biotherapeutics.
Timothy M, Lauer, Neeraj J, Agrawal, Naresh, Chennamsetty, Kamal, Egodage, Bernhard, Helk, Bernhardt L, Trout   +5 more
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Effect of Bovine Sperm‐Bound Antisperm Antibodies on Oviductal Binding Index

Reproduction in Domestic Animals, 2016
ContentsThis study was designed to test the hypothesis that sperm‐bound IgG and IgA decrease binding of bull spermatozoa to oviductal epithelial cells in vitro. Three ejaculates were cryopreserved from each of four antisperm antibody (ASA)‐negative satisfactory breeder bulls. Bulls were then immunized with autologous spermatozoa, and three ASA‐positive
M S, Ferrer, D E, Anderson, L M J, Miller, A, George, M, Miesner, M, Wilkerson   +5 more
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Assessment of the proliferation index in gastric carcinomas with the monoclonal antibody MIB 1

Journal of Cancer Research and Clinical Oncology, 1998
Our study aimed to reveal whether the proliferation index of tumor cells, calculated with the monoclonal antibody (mAb) MIB1, is of prognostic relevance in patients with a gastric carcinoma and shows any correlation to well-known clinicopathological factors (TNM categories, stage, grade, Laurén type).
R, Broll, C, Mahlke, R, Best, H, Schimmelpenning, M W, Strik, T, Schiedeck, H P, Bruch, M, Duchrow   +7 more
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