Results 181 to 190 of about 2,253,953 (246)

Gap‐Free Cannabis sativa Assemblies Reveal Post‐Polyploid Genome Remodelling and Refine the Evolution of Cannabinoid Synthase Genes

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Despite the therapeutic importance of cannabinoids, the scarcity of gap‐free Cannabis genomes has limited the dissection of the genetic and genomic basis of cannabinoid biosynthesis and genome evolution. Here, we generated two haplotype‐phased, gap‐free, gold‐standard assemblies and used them to investigate post‐polyploid genome remodelling ...
Jiangjiang Zhang   +9 more
wiley   +1 more source

Cis‐urocanic acid formation following far‐UVC exposure and associated signaling responses in keratinocytes

open access: yesPhotochemistry and Photobiology, EarlyView.
Far‐UVC (200–235 nm) has emerged as a safe and effective indoor disinfection tool, but effects on skin immunomodulation remain unclear. This study demonstrates that 222 nm far‐UVC converts trans‐urocanic acid (UCA) to its biologically active cis isomer at levels comparable with solar radiation. In keratinocytes, far‐UVC alone caused modest increases in
Lizzie Thomas   +4 more
wiley   +1 more source

The role of acquired host immunity in periodontal diseases

open access: yesPeriodontology 2000, EarlyView.
Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane   +2 more
wiley   +1 more source

Hepatitis B in Organ Transplantation—Current Evidence and Clinical Gaps

open access: yesTransplant Infectious Disease, EarlyView.
ABSTRACT Over the past several decades there have been significant advances in nucleos(t)ide analogue (NA) antiviral therapy for hepatitis B virus (HBV) and global expansion of primary prevention through immunization. Despite this, HBV remains a leading cause of chronic liver disease globally, affecting over 250 million people.
Oscar A. Fernandez‐Garcia   +3 more
wiley   +1 more source

Clinical Effectiveness of the Recombinant Zoster Vaccine for Preventing Herpes Zoster in Individuals With Kidney Transplants: A Retrospective Cohort Study

open access: yesTransplant Infectious Disease, EarlyView.
In this retrospective cohort of kidney transplant recipients, no herpes zoster cases occurred during 398 vaccinated person‐years, compared with 78 cases (16.4 per 1000 person‐years) among unvaccinated recipients. These findings support a protective association of the recombinant zoster vaccine (RZV) and reinforce current recommendations for ...
Kyungsup Kwon   +12 more
wiley   +1 more source

Invasive Fungal Infections in Heart Transplants: A 10‐Year, Single Centre Retrospective Cohort Study From Subtropical Australia

open access: yesTransplant Infectious Disease, EarlyView.
In this 10‐year retrospective cohort study of heart transplant recipients in subtropical Australia, we characterize the incidence and microbiological profile of invasive fungal infections, highlighting the underappreciated burden of late‐onset and non‐Aspergillus mold infections and the potential underdiagnosis of polymicrobial disease.
Angus Lane   +7 more
wiley   +1 more source

WCN25-1826 Tocilizumab – A Hope for Chronic Antibody Mediated Rejection

open access: yesKidney International Reports
Abhishek Vashisth   +8 more
doaj   +1 more source

Post‐Pyloric Enteral Immunoglobulin for Treatment of Chronic Norovirus Diarrhea in Solid Organ Transplant Recipients: A Single Center Retrospective Study

open access: yesTransplant Infectious Disease, EarlyView.
Post‐pyloric enteral Ig was associated with 100% resolution of diarrhea in our small cohort of solid organ transplant recipients with chronic norovirus diarrhea refractory to commonly used interventions like immunosuppression reduction, nitazoxanide, and IVIg.
Fahad Buskandar   +3 more
wiley   +1 more source

Breakthrough Hemolysis in Paroxysmal Nocturnal Hemoglobinuria: Mechanistic Insights and Management Strategies

open access: yesTransfusion, EarlyView.
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder caused by somatic mutations in the PIGA gene, resulting in loss of glycosylphosphatidylinositol (GPI)‐anchored proteins, including the complement regulatory proteins, CD55 and CD59.
Ganesh Raman   +4 more
wiley   +1 more source

Development of a systematic drug screening method for cord blood donation for transfusion to extremely preterm neonates

open access: yesTransfusion, EarlyView.
Abstract Background Cord blood‐derived red blood cell transfusions (CB‐RBCs) are being developed for extremely preterm neonates to preserve physiological fetal hemoglobin levels. We assessed how standard blood donor medication screening could be adapted for this novel donor population.
Jip H. van Daelen   +12 more
wiley   +1 more source

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