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Pathology of Antibody-Mediated Rejection
, 2016 Antibody-mediated rejection (AMR) is now recognized as an important clinical complication of pediatric and adult cardiac transplantation. In addition to causing graft dysfunction, it has been associated with the accelerated development of transplant vasculopathy and graft loss.
Samuel Rotman +3 more
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Clinics in Chest Medicine, 2023
Antibody-mediated rejection (AMR) is a form of lung allograft rejection that is emerging as an important risk factor for chronic lung allograft dysfunction and decreased long-term survival. In this review, we provide a brief overview of our current understanding of its pathophysiology with an emphasis on donor-specific antibodies before moving on to ...
Laura P, Halverson, Ramsey R, Hachem
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Antibody-mediated rejection (AMR) is a form of lung allograft rejection that is emerging as an important risk factor for chronic lung allograft dysfunction and decreased long-term survival. In this review, we provide a brief overview of our current understanding of its pathophysiology with an emphasis on donor-specific antibodies before moving on to ...
Laura P, Halverson, Ramsey R, Hachem
openaire +2 more sources
Current Opinion in Organ Transplantation, 2015
Pulmonary antibody-mediated rejection (AMR) while contributing to acute and chronic allograft dysfunction remains a diagnostic and therapeutic challenge. The diagnostic tenets upon which AMR is defined will be reviewed in the light of recent studies.The introduction of solid phase assays such as the Luminex platform has provided a wealth of ...
Glen P, Westall +2 more
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Pulmonary antibody-mediated rejection (AMR) while contributing to acute and chronic allograft dysfunction remains a diagnostic and therapeutic challenge. The diagnostic tenets upon which AMR is defined will be reviewed in the light of recent studies.The introduction of solid phase assays such as the Luminex platform has provided a wealth of ...
Glen P, Westall +2 more
openaire +4 more sources
Current Opinion in Organ Transplantation, 2017
The review outlines the diagnosis, clinical implications, and treatment strategies for acute and chronic antibody-mediated rejection (AMR) after orthotopic liver transplantation (OLT).A combination of clinical work-up, histopathology, C4d staining, and donor-specific antibody (DSA) should be used to diagnose AMR.
Rachel, Hogen +2 more
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The review outlines the diagnosis, clinical implications, and treatment strategies for acute and chronic antibody-mediated rejection (AMR) after orthotopic liver transplantation (OLT).A combination of clinical work-up, histopathology, C4d staining, and donor-specific antibody (DSA) should be used to diagnose AMR.
Rachel, Hogen +2 more
+5 more sources
Current Opinion in Organ Transplantation, 2012
The diagnosis of antibody-mediated rejection (AMR) has been revolutionized in recent years by advances in the detection of human leukocyte antigen (HLA) and non-HLA antibodies and by the standardized classification of histologic and immunologic changes in endomyocardial biopsies.
Michelle M, Kittleson +1 more
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The diagnosis of antibody-mediated rejection (AMR) has been revolutionized in recent years by advances in the detection of human leukocyte antigen (HLA) and non-HLA antibodies and by the standardized classification of histologic and immunologic changes in endomyocardial biopsies.
Michelle M, Kittleson +1 more
openaire +2 more sources
Antibody-Mediated Rejection and Lung Transplantation
Seminars in Respiratory and Critical Care Medicine, 2021AbstractAntibody-mediated rejection (AMR) is now a widely recognized form of lung allograft rejection, with mounting evidence for AMR as an important risk factor for the development of chronic lung allograft dysfunction and markedly decreased long-term survival.
Laura P, Halverson, Ramsey R, Hachem
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Seminars in Nephrology, 2007
The introduction of both complement 4d (C4d) staining in renal allograft biopsies and sensitive methods to detect anti-human leukocyte antigen antibodies, such as single antigen bead flow assays, into tissue-typing techniques have shown the importance of antibody-mediated alloimmune response in kidney transplantation. The use of these sensitive methods,
Enver, Akalin, Bruno, Watschinger
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The introduction of both complement 4d (C4d) staining in renal allograft biopsies and sensitive methods to detect anti-human leukocyte antigen antibodies, such as single antigen bead flow assays, into tissue-typing techniques have shown the importance of antibody-mediated alloimmune response in kidney transplantation. The use of these sensitive methods,
Enver, Akalin, Bruno, Watschinger
openaire +2 more sources
Antibody-Mediated rejection in the kidney
Transplantation Proceedings, 2004Antibody-mediated rejection is increasingly recognized as a cause of acute and chronic rejection in kidney as well as other organ allografts. New diagnostic criteria have been drafted to diagnose this entity and enable timely therapy.
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Emerging strategies for antibody-mediated rejection
Current Opinion in Organ Transplantation, 2022Purpose of the review Antibody-mediated rejection (AMR) is the leading cause of kidney graft loss. Very few treatment options are available to the clinician to counter this disease process. In this review we describe the available therapeutics and the novel approaches that are being currently developed.
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Cardiac antibody–mediated rejection
Pediatric Transplantation, 2012Chin C. Cardiac antibody–mediated rejection.Abstract: Many factors limit short‐ and long‐term survival after pediatric heart transplantation. Historically, attention had been directed toward T‐cell responses and acute cellular rejection. Presence of pretransplant antibodies against HLA is associated with increased donor wait times and poor post ...
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