Results 161 to 170 of about 10,170,244 (414)

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Multiple Tolerization Subtractive Immunization (MTSI) Protocol: Effects on Mice and Monoclonal Antibody Specificity. [PDF]

Front Immunol, 2021
de Lima Fontes M, Neves FML, Santos KS, Fusco-Almeida AM, Giannini MJSM, Felisbino SL, Deffune E, Moroz A.   +7 more
europepmc   +1 more source

INVESTIGATION OF THE SPECIFICITY OF SUBSTANCES IN SOME HUMAN SERA WHICH ARE INHIBITORY IN CERTAIN VIRAL AND RICKETTSIAL COMPLEMENT-FIXING ANTIGEN-ANTIBODY SYSTEMS [PDF]

, 1956
Nathalie J. Schmidt, Harry B. Harding
openalex   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

THE HUMAN ANTIBODY RESPONSE TO SIMULTANEOUS INJECTION OF SIX SPECIFIC POLYSACCHARIDES OF PNEUMOCOCCUS [PDF]

, 1948
Michael Heidelberger, Colin M. MacLeod, Marie M. di Lapi   +2 more
openalex   +1 more source

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

Molecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen   +13 more
wiley   +1 more source

Sensing antibody functions with a novel CCR8-responsive engineered cell

Acta Biochimica Polonica
Human chemokine receptor 8 (CCR8) is a promising drug target for immunotherapy of cancer and autoimmune diseases. Monoclonal antibody-based CCR8 targeted treatment shows significant inhibition in tumor growth.
Jianyu Hao, Yitong Lv, Xufeng Xiao, Lidan Li, Changyuan Yu   +4 more
doaj   +1 more source

Bayesian Optimization of Antibodies Informed by a Generative Model of Evolving Sequences [PDF]

arXiv
To build effective therapeutics, biologists iteratively mutate antibody sequences to improve binding and stability. Proposed mutations can be informed by previous measurements or by learning from large antibody databases to predict only typical antibodies.
arxiv  

Nature inspired antibody design and optimization [PDF]

, 2017
The biotech industry has seen an explosion in the development of therapeutic antibodies in the last decade. The advantages of antibodies as therapeutics – namely their high affinity, specificity, potency, stability, manufacturability and low toxicity ...
Chowdhury, Ratul, Garde, Shekhar, Julian, Mark, Kumar, Sandeep, Li, Lijuan, Ludwig, Seth, Maranas, Costas, Rabia, Lilia, Tessier, Peter, Tiller, Kathryn   +9 more
core   +1 more source

The purification of azoprotein antibodies by the dissociation of specific precipitates [PDF]

, 1947
Felix Haurowitz, S. Tekman, M Bilen, Paula Schwerin   +3 more
openalex   +1 more source