Results 191 to 200 of about 10,319,593 (322)

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Molecular and clinical dissection of CD24 antibody specificity by a comprehensive comparative analysis

Laboratory Investigation, 2010
G. Kristiansen, Eda Machado, Niko P. Bretz, C. Rupp, K. Winzer, A. König, G. Moldenhauer, F. Marmé, Júlia Costa, P. Altevogt   +9 more
semanticscholar   +1 more source

IgG1 versus IgG3: influence of antibody-specificity and allotypic variance on virus neutralization efficacy. [PDF]

Front Immunol
Kallolimath S, Sun L, Palt R, Föderl-Höbenreich E, Hermle A, Voss L, Kleim M, Nimmerjahn F, Gach JS, Hitchcock L, Chen Q, Melnik S, Eminger F, Lux A, Steinkellner H.   +14 more
europepmc   +1 more source

HCV avidity as a tool for detection of recent HCV infection: sensitivity depends on HCV genotype [PDF]

, 2018
Araujo, Barreiro, Coppola, Coppola, Coughlin, Cunningham, Dominguez, Dore, Feld, Gaudy-Graffin, Genders, Giese, Gower, Grebely, Grebely, Grebely, Grebely, Greiner, Gutiérrez, Hajarizadeh, Hajarizadeh, Hajarizadeh, Hauser, Kanno, Kassanjee, Kassanjee, Kassanjee, Klimashevskaya, Mangia, Martin, Netski, Parekh, Patel, Pawlotsky, Pawlotsky, Polanec, Sacks-Davis, Sagnelli, Shepherd, Sulkowski, Thacker, Thomson, Tomkins, Vickerman, Ward, Wiessing   +45 more
core   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure.

Proceedings of the National Academy of Sciences of the United States of America, 1979
J. Renart, J. Reiser, George R Stark
semanticscholar   +1 more source

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies. [PDF]

Immunity
Wang Y, Lv H, Teo QW, Lei R, Gopal AB, Ouyang WO, Yeung YH, Tan TJC, Choi D, Shen IR, Chen X, Graham CS, Wu NC.   +12 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Molecular and structural basis of anti-DNA antibody specificity for pyrrolated proteins. [PDF]

Commun Biol
Anan Y, Itakura M, Shimoda T, Yamaguchi K, Lu P, Nagata K, Dong J, Ueda H, Uchida K.   +8 more
europepmc   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source