Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
Editorial: Discovery of small molecule lead compounds: a driving force to unravel new anti-cancer targets and mechanisms, volume III. [PDF]
Zhang Y, Fu L, Wang Y.
europepmc +1 more source
Development of a questionnaire to assess the medication literacy of patients receiving oral anticancer drugs. [PDF]
Fehrmann W +6 more
europepmc +1 more source
Rare-Earth Elements at the Interface of Chemistry and Cancer Therapy. [PDF]
Goldiș C +8 more
europepmc +1 more source
Enhancing anticancer peptide discovery: A fusion-centric framework with conditional diffusion for prediction and generation. [PDF]
Li B +6 more
europepmc +1 more source
Metabolic profiling and systems biology analysis of Flammulina filiformis Fv19 extract: an integrated computational and experimental approach for dual anti-cancer and immunomodulatory therapy. [PDF]
El-Sayed H +4 more
europepmc +1 more source
Fifth International Conference of Anticancer Research October 17 - 22, 1995, Corfu, Greece
International Conference of Anticancer Research 1995 Kerkira +1 more
core
Evolution of Thiosemicarbazones: From First- to Second-Generation Metal Chelators and Their Reactive Oxygen Species-Mediated Effects in Melanoma. [PDF]
Alim R, Andrew SD, Parkinson CJ.
europepmc +1 more source
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