Results 141 to 150 of about 10,530,811 (405)
Redox control of multidrug resistance and Its possible modulation by antioxidants [PDF]
, 2016 Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
Cort, A. +4 more
core +3 more sources
Role of Endoplasmic Reticulum Stress in the Anticancer Activity of Natural Compounds
International Journal of Molecular Sciences, 2019 Cancer represents a serious global health problem, and its incidence and mortality are rapidly growing worldwide. One of the main causes of the failure of an anticancer treatment is the development of drug resistance by cancer cells.
P. Limonta +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 A series of novel pyrazolo[3,4-d]pyrimidines was synthesised. Twelve synthesised compounds were evaluated for their anticancer activity against 60 human tumour cell lines by NCI (USA). Compound 7d proved prominent anticancer activity.
Mai Maher +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Anti-cancer peptides from bacteria
Bangladesh Journal of Pharmacology, 2013 Cancer is a leading cause of death in the world. The rapid development of medicine and pharmacology allows to create new and effective anticancer drugs. Among modern anticancer drugs are bacterial proteins.
Tomasz M. Karpinski +1 more
doaj +2 more sources
Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
International Journal of Biomaterials, 2018 Tailoring of chitosan through the involvement of its amino, acetamido, and hydroxy groups can give derivatives of enhanced solubility and remarkable anticancer activity. The general mechanism of such activity is associated with the disturbances in normal
Hari Sharan Adhikari, P. Yadav
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Anticancer Activity of Centaurea babylonica L.
Proceedings, 2017 Today, new agents are required to protect from cancer due to the side effects and some deficiencies in the medical drugs used to treat cancer. Because of this reason, active substances used in drugs which is herbal origin of the treatment of tumors as an
Elif Dündar +2 more
doaj +1 more source
In Vivo Anticancer Activity of a Rhenium(I) Tricarbonyl Complex.
ACS Medicinal Chemistry Letters, 2019 The rhenium(I) complex fac-[Re(CO)3(2,9-dimethyl-1,10-phenanthroline)(OH2)]+ (1) was previously shown to exhibit potent in vitro anticancer activity in a manner distinct from conventional platinum-based drugs (J. Am. Chem. Soc.
Chilaluck C. Konkankit +4 more
semanticscholar +1 more source