Results 41 to 50 of about 529,650 (310)

Bioassays for Anticancer Activities

, 2013
The MTT/MTS in vitro cell proliferation assay is one of the most widely used assays for evaluating preliminary anticancer activity of both synthetic derivatives and natural products and natural product extracts. The highly reliable, colorimetric based assay is readily performed on a wide range of cell lines. This assay gives an indication of whole cell
McCauley, Janice, Zivanovic, Ana, Skropeta, Danielle   +2 more
openaire   +3 more sources

Advances in the design and development of oncolytic measles viruses. [PDF]

, 2015
A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian, Raffel, Corey, Studebaker, Adam W   +2 more
core   +1 more source

Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine [PDF]

, 2020
The organisms thriving under extreme conditions better than any other organism living on Earth, fascinate by their hostile growing parameters, physiological features, and their production of valuable bioactive metabolites.
Amoozegar, Mohammad Ali, Corral Villa, Paulina, Ventosa Ucero, Antonio   +2 more
core   +1 more source

In vitro study of pinostrobin propionate and pinostrobin butyrate: Cytotoxic activity against breast cancer cell T47D and its selectivity index

Journal of Public Health in Africa, 2023
Backgrounds: Pinostrobin has the potential activity as an anti-cancer. However, its activity is still lower than the anticancer drugs on the market. To increase its activity, pinostrobin derivatives have been synthesized, namely pinostrobin propionate ...
Tri Widiandani, Tiffany Tandian, Bagus D. Zufar, Andi Suryadi, Bambang T. Purwanto, Suko Hardjono, Siswandono Siswandono   +6 more
doaj   +1 more source

Anticancer activity of luteolin glycosides

EXCLI journal, 2020
EXCLI Journal;Vol.
openaire   +3 more sources

Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads [PDF]

, 2017
Allosteric compounds that stimulate Hsp90 adenosine triphosphatase (ATPase) activity were rationally designed, showing anticancer potencies in the low micromolar to nanomolar range.
Agard, Da, Bernardi, A, Colombo, G. 1., D'Annessa, I, Moroni, E, Pennati, M, Rasola, Andrea, SANCHEZ MARTIN, Carlos, Sattin, S, Tao, J, Zaffaroni, N   +10 more
core   +1 more source

Antimicrobial activity, antiproliferative activity, amylase inhibitory activity and phytochemical analysis of ethanol extract of corn (Zea mays L.) silk

Current Research in Green and Sustainable Chemistry, 2021
In this study, ethanolic extract of Zea mays L was utilized against urinary tract infection (UTI) causing bacteria, vegetable spoilage causing fungi and anticancer activity.
S. Abirami, M. Priyalakshmi, A. Soundariya, Antony V. Samrot, S. Saigeetha, Renitta R. Emilin, S. Dhiva, L. Inbathamizh   +7 more
doaj   +1 more source

Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy. [PDF]

, 2016
Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II ...
Falchook, Gerald S., Fanale, Michelle A., Fu, Siqing, Garrido-Laguna, Ignacio, Hong, David S., Janku, Filip, Kaseb, Ahmed O., Kurzrock, Razelle, Meric-Bernstam, Funda, Naing, Aung, Park, Haeseong, Patel, Shreyaskumar, Piha-Paul, Sarina A., Subbiah, Vivek, Tsimberidou, Apostolia M., Velez-Bravo, Vivianne M M., Wheler, Jennifer J., Zinner, Ralph G.   +17 more
core   +2 more sources

Anticancer Activity of 4-Aryl-1,4-Dihydropyridines

Future Pharmacology
We have synthesized 22 symmetric and asymmetric 4-aryl-1,4-dihydropyridines (1,4-DHPs) by a “green” microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their cytotoxicity to three human cancer cell lines regarding U-251MG (human ...
Thaís A. S. Oliveira, Jackson B. A. Silva, Tábata R. Esperandim, Nathália O. Acésio, Denise C. Tavares, Antônio E. M. Crotti   +5 more
doaj   +1 more source

Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines [PDF]

Frontiers of Agricultural Science and Engineering, 2015
Twelve (+)-nopinone-based 2-amino-3-cyanopyridines 4a—l were synthesized from (—)-β-pinene. The structures of these compounds were characterized by FT-IR, 1H NMR, and ESI-MS.
Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG
doaj   +1 more source