Results 71 to 80 of about 10,530,811 (405)

Anticancer Activity of Some Bisbenzimidazoles

Zeitschrift für Naturforschung C, 2011
The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. Bisbenzimidazole derivatives are important compounds known as DNA topoisomerase I inhibitors. In the present study, some symmetrical bisbenzimidazole derivatives were synthesized and investigated for their anticancer activity.
Işıkdağ, İlhan, Özkay, Yusuf, İncesu, Zerrin, Akalın Çiftçi, Gülsen   +3 more
openaire   +3 more sources

Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy. [PDF]

, 2016
Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II ...
Falchook, Gerald S., Fanale, Michelle A., Fu, Siqing, Garrido-Laguna, Ignacio, Hong, David S., Janku, Filip, Kaseb, Ahmed O., Kurzrock, Razelle, Meric-Bernstam, Funda, Naing, Aung, Park, Haeseong, Patel, Shreyaskumar, Piha-Paul, Sarina A., Subbiah, Vivek, Tsimberidou, Apostolia M., Velez-Bravo, Vivianne M M., Wheler, Jennifer J., Zinner, Ralph G.   +17 more
core   +2 more sources

Anticancer Activity of Rosmarinus officinalis L.: Mechanisms of Action and Therapeutic Potentials

Nutrients, 2020
Alternative treatments for neoplastic diseases with new drugs are necessary because the clinical effectiveness of chemotherapy is often reduced by collateral effects.
A. Allegra, A. Tonacci, G. Pioggia, C. Musolino, S. Gangemi   +4 more
semanticscholar   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Antitumor Effects of Ursolic Acid through Mediating the Inhibition of STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer Cells

Biomedicines, 2021
Targeted therapy based on natural compounds is one of the best approaches against non-small cell lung cancer. Ursolic acid (UA), a pentacyclic triterpenoid derived from medicinal herbs, has anticancer activity.
Dong Young Kang, Nipin Sp, Jin-Moo Lee, Kyoung-Jin Jang   +3 more
doaj   +1 more source

Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads [PDF]

, 2017
Allosteric compounds that stimulate Hsp90 adenosine triphosphatase (ATPase) activity were rationally designed, showing anticancer potencies in the low micromolar to nanomolar range.
Agard, Da, Bernardi, A, Colombo, G. 1., D'Annessa, I, Moroni, E, Pennati, M, Rasola, Andrea, SANCHEZ MARTIN, Carlos, Sattin, S, Tao, J, Zaffaroni, N   +10 more
core   +1 more source

Peptides with Dual Antimicrobial–Anticancer Activity: Strategies to Overcome Peptide Limitations and Rational Design of Anticancer Peptides

Molecules, 2020
Peptides are naturally produced by all organisms and exhibit a wide range of physiological, immunomodulatory, and wound healing functions. Furthermore, they can provide with protection against microorganisms and tumor cells.
Yamil Liscano, José Oñate-Garzón, J. Delgado   +2 more
semanticscholar   +1 more source

Bis-Pyridazine Derivatives with Anticancer Activity

Proceedings, 2019
Over the last decades, pyridazine derivatives are considered “privileged structures” in medicinal chemistry, with special attention being given to pyridazinones derivatives, which were found to have a large range of biological activities ...
Amariucai-Mantu Dorina, Mangalagiu I. Ionel, Antoci Vasilichia, Mangalagiu Violeta   +3 more
doaj   +1 more source

Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex [PDF]

, 2011
This first in vivo antitumour activity for an organometallic osmium arene complex, [Os(eta(6)-p-cym)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF(6), is reported. The complex delays the growth of HCT116 human colon cancer xenografts in mice, with negligible
Cooper, Patricia A., Fu, Y. (Ying), Habtemariam, Abraha, Loadman, Paul M., Rijt, Sabine H. van, Sadler, P. J., Shnyder, Steve D.   +6 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source