Results 91 to 100 of about 6,504,034 (299)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Comparative Phytochemical Characterization of Turkish Propolis Extracts and Their Antioxidant, Antibacterial, and Anticancer Activities

Molecules
Geographical and botanical origin dominate the chemical composition and biological activity of propolis samples. In this study, thirty Turkish propolis samples collected from different regions within the Black Sea region were comprehensively evaluated to
Serhat Karabıcak, Oktay Bıyıklıoğlu, Şeymanur Aktaş, Derya Keleşoğlu Kalemkaş, Demet Erdağ, Tarık Mecit, Selin Çeter, Idris Yazgan, Talip Çeter   +8 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Bioactivity-Guided Fractionation, Characterization, and Mechanistic Insights of Anticancer Agents from Simarouba glauca DC. Leaves

Molecules
Although Simarouba glauca DC. has been recognized for its therapeutic properties, its anticancer effects against oral cancer have not been adequately investigated. The present study aimed to evaluate the activity of S.
Sushma Rudraswamy, Yashaswini Devi G. V., Sreeshyla H. Sheshanna, Nagabhushana Doggalli, SubbaRao V. Madhunapantula   +4 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Anticancer Effects of Synthetic Phosphoethanolamine on Ehrlich Ascites Tumor: An Experimental Study

, 2012
Background: Antineoplastic phospholipids (ALPs) represent a promising class of drugs with a novel mode of action undergoes rapid turnover in the cell membrane of tumors, interfering with lipid signal transduction, inducing cell death.
Meneguelo, Renato, Ribeiro Filho, Otaviano Mendonça, Chierice, Gilberto Orivaldo, Maria, Durvanei Augusto, Pereira, Alexandre, Ferreira, Adilson Kleber   +5 more
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Carotenoids, their structure, properties and biological action

Біологічні студії, 2010
Dependence of antioxidant properties upon structural features of carotenoids and structure of carotenoids itself are reviewed in this paper. Literature data concerning assimilation and accumulation of these substances in cell generalized in the article ...
M. Simonova
doaj   +1 more source

Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC “click” chemistry as potential anticancer agents

, 2014
Xin Jin1,2,* Tian-Hua Yan,3,* Lan Yan,1 Qian Li,4 Rui-Lian Wang,1 Zhen-Lin Hu,1 Yuan-Ying Jiang,1 Qing-Yan Sun,1 Yong-Bing Cao1 1School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China; 2School of Pharmacy, FuJian
Yan L, Jin X, Yan TH, Wang RL, Cao YB, Hu ZL, Sun QY, Li Q, Jiang YY   +8 more
core  

Anticancer activity of ML6 against a cancer cell line panel.

, 2020
Anticancer activity of ML6 against a cancer cell line panel.
Erica A. Langford (8491575), Carly E. Hawkins (8491578), Janna N. Sloand (3594338), Jacob A. Halle (8491584), Atip Lawanprasert (8491569), Scott H. Medina (1641949), James H. Marden (8491587), Caitlin A. Guinan (8491572), Matthew R. Aronson (8491581), Howard W. Fescemyer (3295140)   +9 more
core   +1 more source