Results 71 to 80 of about 11,879,963 (351)

The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis [PDF]

, 2012
Recent data from the AZURE, ABCSG-12, and ZO-FAST clinical trials have challenged our understanding of the potential anticancer activity of zoledronic acid (ZOL). Although the results of these studies may appear to be conflicting on the surface, a deeper
Arrington, Avcu, Baum, Bilezikjian, Binkley, Bismar, Black, Bourdeau, Brown, Bundred, Burger, Burger, Centrella, Chapman, Cheleuitte, Chiu, Clowes, Coleman, Coscia, Coxon, Croucher, de Boer, Del Mastro, Dixon, Duivenvoorden, Edlund, Edlund, Esparza-Lopez, Folkerd, Gasser, Gasser, Geisler, Giraudo, Gnant, Gnant, Gnant, Gnant, Gordon, Guo, Hackshaw, Hamilton, Hampl, Hershman, Hershman, Hines, Hiraga, Hofbauer, Hornby, Ibrahim, Jimenez-Gordo, Juarez, Kaplan, Kaplan, Kardassis, Khosla, Kirkbride, Labrinidis, Le Goff, Lee, Lewis, Lindberg, Little, Little, Meads, Melani, Monkkonen, Muller, Nicks, Ogata, Ottewell, Ottewell, Ottewell, Pataki, Perrien, Perrien, Peyruchaud, Pfeilschifter, Podworny, Rachner, Rannevik, Roelofs, Rogers, Rosen, Rosen, Saika, Sasser, Sasser, Shiozawa, Shipman, Sims, Sirola, Skerjanec, Sowers, Studebaker, Sun, Tang, Thompson, Thurlimann, Uncu, van de Velde, Weiss, Wels, Welt, Wiater, Winter   +104 more
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines [PDF]

Frontiers of Agricultural Science and Engineering, 2015
Twelve (+)-nopinone-based 2-amino-3-cyanopyridines 4a—l were synthesized from (—)-β-pinene. The structures of these compounds were characterized by FT-IR, 1H NMR, and ESI-MS.
Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG
doaj   +1 more source

PEGylated nano-graphene oxide as a nanocarrier for delivering mixed anticancer drugs to improve anticancer activity

Scientific Reports, 2020
Due to their high specific surface area, graphene oxide and graphene oxide-base nanoparticles have great potential both in dual-drug delivery and combination chemotherapy.
X. Pei, Zhou Zhu, Zhoujie Gan, Junyu Chen, Xin Zhang, Xinting Cheng, Q. Wan, Jian Wang   +7 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Bis-Pyridazine Derivatives with Anticancer Activity

Proceedings, 2019
Over the last decades, pyridazine derivatives are considered “privileged structures” in medicinal chemistry, with special attention being given to pyridazinones derivatives, which were found to have a large range of biological activities ...
Amariucai-Mantu Dorina, Mangalagiu I. Ionel, Antoci Vasilichia, Mangalagiu Violeta   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]

, 2019
Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y., Kankia, Ibrahim H., Langdon, Simon P., Paramasivan, Poornima   +3 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Berberine hydrochloride: anticancer activity and nanoparticulate delivery system

International Journal of Nanomedicine, 2011
Wen Tan, Yingbo Li, Meiwan Chen, Yitao WangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, ChinaBackground: Berberine hydrochloride is a ...
Tan W, Li YB, Chen MW, Wang YT
doaj