Results 161 to 170 of about 170,034 (262)

Cardamonin as a potential anticancer agent: Preclinical insights and clinical implications. [PDF]

World J Clin Oncol
Badroon NA, Alsalahi A, Aljaberi MA, Abdul Majid N, Alshawsh MA.   +4 more
europepmc   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Efficacy of DNA Intercalator-Conjugated Triplex-Forming Oligonucleotide as Anticancer Agent. [PDF]

ChemMedChem
Toyama H, Toriba A, Shibata A, Wada T, Yamayoshi A, Mikame Y.   +5 more
europepmc   +1 more source

Human‐Centered Innovation: Precision Nutrition and the Future of Food

Advanced Science, EarlyView.
ABSTRACT Nutritional science is moving beyond one‐size‐fits‐all recommendations toward more precise and personalized approaches, yet its implementation pathway remains unclear. This paper proposes a human‐centered precision nutrition framework that highlights the central roles of artificial intelligence (AI), food innovation, and human agency.
Shanshan Zhang, Yonggan Sun, Jiaqi Jiang, Shaoping Nie   +3 more
wiley   +1 more source

A novel synthetic melanin as a potential anticancer agent that induces apoptosis and cyclin D downregulation through distinct pathways. [PDF]

J Biol Chem
Kawamoto Y, Furuhashi Y, Ilmiyah SZ, Yamaguchi S, Nishimura N, Iwata R, Imoto A, Murate T, Ohmi Y, Permana S, Endharti AT, Ueno Y, Iida M, Yajima I, Ohgami N, Kato M, Takeda K.   +16 more
europepmc   +1 more source

Forced Bcl-2 expression induced prevented roscovitine induced-autophagy via in PC3 cells” 3rd AntiCancer Agent Development Congress [PDF]

, 2015
Acar, Sevilay, YERLİKAYA, PINAR OBAKAN, ARISAN, ELİF DAMLA, Gümüşkaptan, Çağrı, Berrak, Özge   +4 more
core  

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Recent Advances in the Application of Cucurbitacin B as an Anticancer Agent. [PDF]

Int J Mol Sci
Yin D, Chen H, Lin S, Sun Y, Jing X, Chang R, Feng Y, Dong X, Qu C, Ni J, Yin X.   +10 more
europepmc   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Cephalomannine as in vitro and in vivo anticancer agent in mesothelioma cells: mechanisms of action. [PDF]

BMC Cancer
Morani F, Dell'Anno I, Daga A, Doccini S, Bisceglia L, Gemignani F, Landi S.   +6 more
europepmc   +1 more source