Results 181 to 190 of about 170,034 (262)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

A Silibinin-Poly(ε-Caprolactone) Conjugate as an Enhanced Anticancer Agent. [PDF]

Macromol Biosci
Vento F, Privitera A, Caruso G, Nicosia A.   +3 more
europepmc   +1 more source

Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy

Advanced Science, EarlyView.
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru, Priyanka Bhattacharyya, Mingxu You   +2 more
wiley   +1 more source

Green-synthesized zinc oxide nanoparticles using Echinops spinosus extract: A promising anticancer agent for hepatocellular carcinoma. [PDF]

PLoS One
Hamad RS, Elshaer MAA, El-Mahdy HA, Mohammed OA, Jeelani M, Doghish AS, Abd-Elraheem MAM, Abdel Mageed MM, Darwish AA, Ibrahim EK, El-Dakroury WA.   +10 more
europepmc   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

A Silver-Copper-Aluminum Layered Double Hydroxide Sensor for Sensitive Determination of Anticancer Agent Afatinib in Bulk and Biological Fluids. [PDF]

ACS Omega
Gabiam EN, Erk N, Bay MS, Genc AA, Ahmed HEH, Soylak M.   +5 more
europepmc   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Novel 3-Methyl-1,6-Diazaphenothiazine as an Anticancer Agent-Synthesis, Structure, and In Vitro Anticancer Evaluation. [PDF]

Molecules
Morak-Młodawska B, Martula E, Jeleń M, Beberok A, Rzepka Z, Musiał S, Małek S, Karkoszka-Stanowska M, Wrześniok D.   +8 more
europepmc   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Repurposing an antimicrobial arginine-rich decapeptide as a novel anticancer agent: Evidence from <i>in vitro</i> and <i>in vivo</i> breast cancer models. [PDF]

Iran J Basic Med Sci
Chamani R, Mohammadi M.
europepmc   +1 more source