Results 61 to 70 of about 170,034 (262)

Advanced non-linear mathematical model for the prediction of the activity of a putative anticancer agent in human-to-mouse cancer xenografts [PDF]

, 2020
Summarization: Background/Aim: Mathematical models have long been considered as important tools in cancer biology and therapy. Herein, we present an advanced non-linear mathematical model that can predict accurately the effect of an anticancer agent on ...
Λιλιοπουλος Σωτηριος(http://users.isc.tuc.gr/~sliliopoulos), Dimas Konstantinos S., Σταυρακακης Γεωργιος(http://users.isc.tuc.gr/~gstavrakakis), Liliopoulos Sotirios(http://users.isc.tuc.gr/~sliliopoulos), Stavrakakis Georgios(http://users.isc.tuc.gr/~gstavrakakis)   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Development and Characterization of Solid Lipid Nanoparticles Loaded with a Highly Active Doxorubicin Derivative

Nanomaterials, 2018
Solid lipid nanoparticles (SLNs) comprise a versatile drug delivery system that has been developed for the treatment of a variety of diseases. The present study will investigate the feasibility of entrapping an active doxorubicin prodrug (a squalenoyl ...
Barbara Stella, Elena Peira, Chiara Dianzani, Marina Gallarate, Luigi Battaglia, Casimiro Luca Gigliotti, Elena Boggio, Umberto Dianzani, Franco Dosio   +8 more
doaj   +1 more source

Trioxacarcin A Interactions with G‑Quadruplex DNA Reveal Its Potential New Targets as an Anticancer Agent [PDF]

, 2023
Trioxacarcin (TXN) A was reported to be an anticancer agent through alkylation of dsDNA. G-quadruplex DNA (G4-DNA) is frequently formed in the promoter regions of oncogenes and the ends of telomerase genes, considered as promising drug targets for ...
Chunxi Wang (3120366), Chunxi Wang, Chunyang Cao, Wenxian Lan, Xianfeng Hou (15425975), Wenxian Lan (197512), Hongjuan Xue, Shaowen Yin, Zhijun Liu (35566), Xianfeng Hou, Zhijun Liu, Hongjuan Xue (15425978), Gong-Li Tang, Shaowen Yin (15425972), Gong-Li Tang (1829416), Chunyang Cao (197526)   +15 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Determining the Anticancer Activity of Sphingosine Kinase Inhibitors Containing Heteroatoms in Their Tail Structure

Pharmaceutics, 2022
Sphingosine kinase (SK) enzyme, a central player of sphingolipid rheostat, catalyzes the phosphorylation of sphingosine to the bioactive lipid mediator sphingosine 1 phosphate (S1P), which regulates cancer cell proliferation, migration, differentiation ...
Jitendra Shrestha, Seong Woong Kim, Su-Bin Kim, Yoon Sin Oh, Sung Hwan Ki, Taeho Lee, Sang-Bum Kim, Taeuk Park, Dong Jae Baek, Eun-Young Park   +9 more
doaj   +1 more source

Vitamin C and K3 Combination Causes Enhanced Anticancer Activity against RT-4 Bladder Cancer Cells [PDF]

, 2013
Introduction: Vitamin C (VC), Vitamin K3 (VK3) and the combination (VC:VK3) were evaluated against human bladder cancer cell lines RT-4 and T24 to evaluate their synergistic anticancer activity.
Gilloteaux, Jacques, Summers, Jack, Jamison, James, McGuire, Karen   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Systemic delivery of the anticancer agent arenobufagin using polymeric nanomicelles [PDF]

, 2017
Xue Yuan,1,2 Qian Xie,1 Keyu Su,1 Zhijie Li,3 Dong Dong,3 Baojian Wu1,2 1Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, 2Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research ...
Dong D, Li Z, Wu B, Su K, Yuan X, Xie Q
core  

Newly Modified Nanoformulation of Quercetin as Promising Chemotherapeutic Anticancer Agent [PDF]

, 2023
Previous studies have demonstrated the potential anticancer effect of quercetin (QUR). However, water insolubility and less bioavailability of QUR reduce its efficiency in cancer therapy.
El-Far, Mohamed, Abd El-Azim, Amira O., Yahia, Sarah, El-Sherbiny, Ibrahim M., El-Senduny, Fardous F., Essam, Alaa   +5 more
core   +1 more source