Results 81 to 90 of about 715,175 (219)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

A 1% glycopyrronium bromide cream for topical treatment of severe primary axillary hyperhidrosis in adolescents: safety, local tolerability, systemic exposure and efficacy from an open‐label phase II study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Primary axillary hyperhidrosis (PAHH) results from dysregulation of the autonomic nervous system and typically begins during puberty. Treatment options for adolescents remain limited. This open‐label phase II study evaluated the safety, local tolerability, systemic exposure, and efficacy of 1% GPB cream over 8 weeks in
Rolf‐Markus Szeimies, Ana Kilic, Hubert Reich, Birgit Berger, Erik Schulze zur Wiesche, Leonie Litzka, Katharina Schramm, Susanne Heimstaedt‐Muskett, Clarissa Masur   +8 more
wiley   +1 more source

Anticholinergic burden and chronic kidney disease progression

International audienceBackground and objective(s)A growing body of evidence highlights the role of the anticholinergic system through anti-inflammatory and vasoregulatory pathways.
Metzger, M., Massy, Z., Laville, S., Mouheb, A., Liabeuf, S., Levassort, H., Pinho, N. Alencarde, Pépin, M., Laville, M.   +8 more
core   +1 more source

Effects of Anticholinergic Burden on Verbal Memory Performance in First-Episode Psychosis

, 2023
Antipsychotics are widely used to treat first-episode psychosis but may have an anticholinergic burden, i.e., a cumulative effect of medications that block the cholinergic system.
Ashok Malla, Jai Shah, Carolina Makowski, Agnès Belkacem, M. Mallar Chakravarty, Martin Lepage, Katie M. Lavigne, Ridha Joober   +7 more
core   +3 more sources

Charting the course of Sjögren's disease: A historical analysis of scientific progress

European Journal of Oral Sciences, EarlyView.
Abstract Sjögren's disease (SjD) bears the name of the Swedish ophthalmologist Henrik Sjögren. His 1933 doctoral thesis on keratoconjunctivitis sicca ignited interest, yet much remains under debate. SjD is an autoimmune disorder that primarily affects the exocrine glands, particularly the salivary and lacrimal glands, leading to a dryness of the eyes ...
Diego Ustárroz Cantali, Fabiola Reis de Oliveira, Denise Cantarelli Machado, Moisés Evandro Bauer   +3 more
wiley   +1 more source

Anticholinergic burden and clinical outcomes among older adults admitted in a tertiary hospital: a prospective cohort study.

PLoS ONE
BackgroundAnticholinergic medication use is associated with adverse clinical outcomes, especially in older adults. However, few studies have assessed the anticholinergic burden in the Thai geriatric population.
Pornkamol Tiranaprakij, Sahaphume Srisuma, Krongtong Putthipokin, Sirasa Ruangritchankul   +3 more
doaj   +1 more source

Management of chronic urticaria: Current status and future prospect

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman, Mona Al‐Ahmad, Maryam Al‐Nesf, Chia‐Yu Chu, Luis Felipe Ensina, Ana M. Gimenez‐Arnau, Margarida Gonçalo, Clive Grattan, Michihiro Hide, Pavel Kolkhir, Martin Metz, Iman Nasr, Romi Saini, Simon Francis Thomsen, Torsten Zuberbier, Emek Kocaturk   +15 more
wiley   +1 more source

Patient Outcomes Associated With a Composite Measure of 4Ms Care Adherence in the Inpatient Setting

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background The 4Ms (what matters, medication, mentation, and mobility) is a widely adopted age‐friendly care framework. However, there is no evidence on inpatient 4Ms adherence thresholds associated with improved outcomes. Methods In a retrospective cross‐sectional analysis, we measured encounter‐level adherence to the 4Ms for inpatients 65 ...
Benjamin I. Rosner, Robert L. Thombley, Stephanie E. Rogers, Julia Adler‐Milstein   +3 more
wiley   +1 more source

Anticholinergic Burden and its Association with Sleep

, 2017
As people age they are more likely to develop chronic conditions and will tend to be on multiple medications for long periods of time to manage those conditions. Some of these medications have side effects that are anticholinergic in nature.
Barker, Craig D.
core   +1 more source

Association between drugs with anticholinergic effects and mortality in patients on hemodialysis

Renal Replacement Therapy
Background Patients undergoing hemodialysis frequently receive medications with anticholinergic effects, yet evidence linking cumulative anticholinergic burden to outcomes in this population is scarce.
Yu Honda, Shunichiro Orihara, Suguru Yamamoto, Shingo Fukuma, Yoshihiro Onishi, Takashi Yokoo, Kazuhiko Tsuruya   +6 more
doaj   +1 more source