Results 101 to 110 of about 715,175 (219)

Anterior Drooling Versus Posterior Drooling: A Comparative Analysis

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aims To examine the patient population of a tertiary Interdisciplinary Saliva Control Clinic, describe management pathways and identify patients suitable for primary care. Methods Retrospective single‐centre cohort study in a tertiary hospital reviewing patients referred to the Saliva Control Clinic over a 5‐year period.
Kaitlin Duell, Eric Levi, Will Alexander, David Chong, Monica S. Cooper   +4 more
wiley   +1 more source

Nationwide trends in psychiatric prescription practices for drugs with putative cognitive adverse effects in schizophrenia spectrum and bipolar disorders from 2013 to 2022

Journal of Pharmaceutical Policy and Practice
Background The management of schizophrenia spectrum (SZ) and bipolar disorders (BD) can involve psychotropic polypharmacy, high psychotropic doses, a high anticholinergic burden, and the use of anticholinergic agents and benzodiazepines, which are ...
Nathan Vidal, Solène Frileux, Nadia Younès, Emmanuelle Corruble, Christine Passerieux, Eric Brunet-Gouet, Paul Roux   +6 more
doaj   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review

, 2015
Background: The cumulative effect of taking multiple medicines with anticholinergic properties termed as anticholinergic burden can adversely impact cognition, physical function and increase the risk of mortality. Expert opinion derived risk scales are
Nishtala, PS (15593765), Mohammed Salahudeen (14748604), Duffull, SB (15674789)   +2 more
core  

Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling

Oral Diseases, EarlyView.
ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung, Soohyun Kim, Yoo‐Bin Kim, Hee‐Kyung Park, Se‐Young Choi   +4 more
wiley   +1 more source

Assessing the Anticholinergic Cognitive Burden Classification of Putative Anticholinergic Drugs Using ADME Properties

British Journal of Clinical Pharmacology
Aim: This study evaluated the use of machine learning in leveraging drug ADME data to develop a novel anticholinergic burden (AB) scale and compared its performance to previously published scales. Methods: Experimental and in silico ADME data were collected for antimuscarinic activity, blood-brain barrier penetration, bioavailability, chemical ...
Geofrey Oteng Phutietsile, Nikoletta Fotaki, Prasad S. Nishtala   +2 more
openaire   +2 more sources

Salivary Apelin Levels and Periodontal Findings in Individuals With/Without Type 1 Diabetes and Varying Degrees of Gingival Inflammation

Oral Diseases, EarlyView.
ABSTRACT Objective To evaluate salivary apelin levels in individuals with and without type 1 diabetes presenting an intact periodontium and varying degrees of plaque‐induced gingival inflammation. Methods Saliva samples were collected; and whole‐mouth clinical periodontal measurements were recorded in type 1 diabetes and systemically healthy ...
Demet Efe Yavaşoğlu, Andressa V. B. Nogueira, Mehmet Demirbaş, Timur Köse, Sebahat Kaya, James Deschner, Nurcan Buduneli   +6 more
wiley   +1 more source

Anticholinergic and sedative medication burden in older adults: an observational analysis

Geriatric Care
The cumulative effects of multiple medications with anticholinergic and sedative properties, referred to as anticholinergic and sedative burdens, can result in adverse effects in older adults.
Jehath Syed, Prathibha Pereira, Tejaswini C J, Shilpa Avarebeel, Kshama Ramesh, Madhan Ramesh, Krishna Undela, Sri Harsha Chalasani   +7 more
doaj   +1 more source

Intestinal epithelial injury and inflammation after physical work in temperate and hot environments in older men with hypertension or type 2 diabetes

Experimental Physiology, EarlyView.
Abstract We tested whether older adults with well‐controlled type 2 diabetes or hypertension, compared with age‐matched adults without chronic disease, exhibit greater intestinal damage, microbial translocation and inflammation during exertional heat stress.
Ben J. Lee, Tessa R. Flood, Sophie L. Russell, James J. McCormick, Kelli E. King, Naoto Fujii, Tatsuro Amano, Sean Notley, Glen P. Kenny   +8 more
wiley   +1 more source

Pneumonia Risk, Antipsychotic Dosing, and Anticholinergic Burden in Schizophrenia

JAMA Psychiatry
ImportanceAntipsychotic drugs (particularly clozapine) have been associated with pneumonia in observational studies. Despite studies of the associations between antipsychotic use and incident pneumonia, it remains unclear to what degree antipsychotic use is associated with increased risk of pneumonia, whether dose-response associations exist, and what ...
Luykx, Jurjen J., Correll, Christoph U., Manu, Peter, Tanskanen, Antti, Hasan, Alkomiet, Tiihonen, Jari, Taipale, Heidi   +6 more
openaire   +6 more sources