Results 91 to 100 of about 715,175 (219)

Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Down syndrome (DS) entails widespread age‐related functional decline affecting multiple organ systems, including genetically determined early‐onset Alzheimer disease (DSAD), resulting in an increased vulnerability to frailty early in life.
Georg Nübling, Lena Marth, Katja Sandkühler, Anna Stockbauer, Elisabeth Wlasich, Alexander Jäck, Olivia Wagemann, Julia Kustermann, Steffen Halbgebauer, Hayrettin Tumani, Günter Höglinger, Johannes Levin   +11 more
wiley   +1 more source

Anticholinergic Medication Burden Scales: A Systematic Review

Journal of the American Geriatrics Society
ABSTRACT Background Anticholinergic burden refers to the cumulative anticholinergic effect of all medications taken by an individual. Anticholinergic burden scales help identify patients at risk of anticholinergic adverse effects and guide prescribing.
Orla Vennard, Carrie Stewart, Mansi Tolia, Roy L. Soiza, Phyo K. Myint   +4 more
openaire   +2 more sources

Cancer co‐medication quality in older patients with polypharmacy: A large randomized trial testing a medication review versus usual care

Journal of Internal Medicine, EarlyView.
Abstract Background Evidence from randomized controlled trials (RCTs) testing medication reviews in geriatric oncology is sparse. Methods We conducted a single‐blinded RCT in ten rehabilitation clinics across Germany. Patients with common cancers, aged ≥ 65 years, and polypharmacy (regularly ≥ five drugs) were randomly allocated in equal proportions to
Miriam Degen, Annette Kopp‐Schneider, Tomislav Vlaski, Sigrid Carlsson, Peter Hallermann, Ludmilla Jewlanowa, Jana Barinoff, Valentin Goede, Christian Lüders, Thomas Kiefer‐Trendelenburg, Diana Lüftner, Jasmin Doll, Jürgen Wagner, Birgit Leibbrand, Hermann Brenner, Ben Schöttker   +15 more
wiley   +1 more source

Anticholinergic burden and dry mouth among Finnish, community-dwelling older adults [PDF]

, 2017
Objective: The aim was to study whether the anticholinergic burden of drugs is related to xerostomia and salivary secretion among community‐dwelling elderly people.Background: Anticholinergic drugs have been shown to be a risk factor for dry mouth, but ...
Pekka Ylöstalo, Taipale, Heidi, Heidi Taipale, Sirpa Hartikainen, Anna-Maija Syrjälä, Lampela, Pasi, Knuuttila, Matti, Ylöstalo, Pekka, Tiisanoja, Antti, Antti Tiisanoja, Matti Knuuttila, Syrjälä, Anna-Maija, Hartikainen, Sirpa, Komulainen, Kaija, Pasi Lampela, Kaija Komulainen   +15 more
core   +1 more source

Recurrent UTIs in Children With CAKUT

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Congenital abnormalities of the kidney and urinary tract (CAKUT) encompass diverse diagnoses that commonly present as urinary tract dilatation and are the leading cause of kidney failure in children. Antenatal hydronephrosis occurs in ~1% of pregnancies; most resolve spontaneously, but conditions such as posterior urethral valves (PUV ...
Lucielle Standish, Holly Campbell, Shehryar Saharan, Lilian M. Johnstone, Neil Price, Chris Kimber, Kiarash Taghavi   +6 more
wiley   +1 more source

Disentangling drug contributions: anticholinergic burden in older adults linked to individual medications: a cross-sectional population-based study

BMC Geriatrics
Background Medications with potent anticholinergic properties have well-documented adverse effects. A high cumulative anticholinergic burden may arise from the concurrent use of multiple medications with weaker anticholinergic effects.
Gauri Bhatkhande, Niteesh K. Choudhry, Mufaddal Mahesri, Nancy Haff, Julie C. Lauffenburger   +4 more
doaj   +1 more source

A Pilot Placebo‐Controlled Randomized Trial of Repeated High‐Dose Intravenous Magnesium Sulphate and High‐Dose Nebulized Budesonide for Severe Asthma in the Paediatric Emergency Department

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Objective Determine if high‐dose intravenous magnesium with/without nebulized budesonide for children with acute severe asthma is safe and reduces time to medical readiness for discharge compared to standard intravenous magnesium. Methods Either 2 doses of intravenous magnesium or 1 dose and placebo, each with/without high‐dose nebulized ...
Khalid Alansari, Fatin Abou Moussa, Hadi Abu Rasheed, Bruce L. Davidson, Khalid Yousif Ibrahim, Mahmoud Alrifaai   +5 more
wiley   +1 more source

Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy

Acta Pharmaceutica
This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population.
Jazbar Janja, Locatelli Igor, Kos Mitja
doaj   +1 more source

Management of Monosymptomatic Nocturnal Enuresis in Children: A Pilot Randomised Control Trial of Body‐Worn Versus Bell‐and‐Pad Alarm Device

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim To compare bell‐and‐pad alarm therapy to body‐worn alarm therapy for the management of monosymptomatic enuresis in children 6–16 years of age in Victoria, Australia. Method A sample of 76 children with monosymptomatic enuresis were randomly allocated to a control group (bell‐and‐pad alarm, n = 38) or an experimental group (body‐worn alarm,
Blake Peck, Daniel Terry, Bronwyn Peck, Andrea Green, Kerrie Svedas, Shirley Whitaker, Monica Harrop, Erica Pearce, Mark Nethercote, Natasha Burgess, Ha N. D. Le, Sithara Wanni Arachchige Dona, Susan Gibb   +12 more
wiley   +1 more source

Association of anticholinergic cognitive load with the appointment of potentially not recommended drugs and the frequency of hospitalization of elderly and senile patients

Качественная клиническая практика, 2019
Actuality. The pharmacotherapy practice in elderly and senile patients is characterized by a widespread use of drugs with anticholinergic properties. Available data indicate that the combined anticholinergic cognitive burden correlates with the risk of ...
A. M. Al-Rajawi, S. K. Zyryanov, E. A. Ushkalova, O. I. Butranova, A. P. Pereverzev   +4 more
doaj   +1 more source