Results 111 to 120 of about 346,610 (333)

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

open access: yesAdvanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu   +11 more
wiley   +1 more source

State of plasma hemostasis in patients with hypertension in combination with non-alcoholic fatty liver disease

open access: yesJournal of Education, Health and Sport, 2018
Background. Among liver diseases, non-alcoholic fatty liver disease (NAFLD) is the most common. NAFLD is an independent risk factor for the development and progression of cardiovascular diseases. Objective.
N. Bazhenova
doaj  

Prior Direct Oral Anticoagulant Therapy is Related to Small Infarct Volume and No Major Artery Occlusion in Patients With Stroke and Non‐Valvular Atrial Fibrillation

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background The aims of the present study were to investigate the relationships between prior direct oral anticoagulant (DOAC) therapy and infarct volume and the site of arterial occlusion in patients with acute ischemic stroke and non‐valvular atrial ...
Yuki Sakamoto   +12 more
doaj   +1 more source

Enantioselective Alkoxycarbonyl‐Lactonization of Alkenes via the Merger of Photoredox and Copper Catalysis

open access: yesAdvanced Science, EarlyView.
A highly enantioselective alkoxycarbonyl‐lactonization of alkenes is reported through a photoredox/copper dual‐catalyzed alkoxycarbonyl radical addition/cyclization reaction. Abstract The synthesis of ester derivatives represents one of the most significant and fundamental tasks in modern organic chemistry, and numerous methods have been developed in ...
Yuping Xiong   +5 more
wiley   +1 more source

Successful treatment of massive thrombosis of the vena cava inferior with nephrоtic syndrome and chronic bilateral pulmonary artery thromboembolism in a patient with genetic thrombophilia

open access: yesТерапевтический архив, 2012
A case is reported of a 23-year-old male patient who developed, after severe blunt injury of the lumbar region, massive thrombosis of the vena cava inferior (VCI), both renal veins, bilateral pulmonary artery thromboembolism (PATE), nephrоtic syndrome ...
Ol'ga Vladimirovna Blagova   +31 more
doaj  

Risk Stratification Using the CHA2DS2‐VASc Score in Takotsubo Syndrome: Data From the Takotsubo Italian Network

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe CHA2DS2‐VASc score predicts stroke in patients with atrial fibrillation and has been reported to have a prognostic role even in acute coronary syndrome patients.
Guido Parodi   +12 more
doaj   +1 more source

Preliminary Report on the Clinical Use of a New Anticoagulant, Phenylindandione [PDF]

open access: bronze, 1950
ANCEL U. BLAUSTEIN   +3 more
openalex   +1 more source

Aloe‐Emodin Targeting FOXC2 Disrupts NETs Formation and EMT‐Driven Postoperative Peritoneal Adhesion Through TGF‐β1‐Smad2/3 Pathway

open access: yesAdvanced Science, EarlyView.
Forkhead box protein C2 (FOXC2) is highlighted as a pivotal effector in postoperative peritoneal adhesion (PPA) formation. Mechanically, FOXC2 mediates NETs‐induced EMT alterations through the TGF‐β1‐Smad2/3 pathway. Aloe‐emodin (AE) ameliorates FOXC2‐driven fibrosis by blocking NETs formation and EMT changes through this pathway.
Lili Yang   +10 more
wiley   +1 more source

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