Results 1 to 10 of about 24,700 (187)

An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting [PDF]

Nature Communications
RNA post-transcriptional modifications act by stabilizing the functional conformations of RNA. While their role in messenger RNA (mRNA) decoding is well established, it is less clear how transfer RNA (tRNA) modifications outside the anticodon contribute ...
Evelyn M. Kimbrough, Ha An Nguyen, Haixing Li, Jacob M. Mattingly, Nevette A. Bailey, Wei Ning, Howard Gamper, Ya-Ming Hou, Ruben L. Gonzalez, Christine M. Dunham   +9 more
doaj   +2 more sources

Anticodon table of the chloroplast genome and identification of putative quadruplet anticodons in chloroplast tRNAs

Scientific Reports, 2023
The chloroplast genome of 5959 species was analyzed to construct the anticodon table of the chloroplast genome. Analysis of the chloroplast transfer ribonucleic acid (tRNA) revealed the presence of a putative quadruplet anticodon containing tRNAs in the ...
Tapan Kumar Mohanta, Yugal Kishore Mohanta, Nanaocha Sharma   +2 more
doaj   +3 more sources

Integrating tRNA gene epigenomics and expression with codon usage unravels an intricate connection with translatome dynamics in Trypanosoma cruzi [PDF]

mBio
Codon usage bias impacts protein expression across all kingdoms of life, including trypanosomatids. These protozoa, such as the Trypanosoma cruzi, primarily regulate their protein-coding genes through posttranscriptional mechanisms.
Herbert G. S. Silva, Satoshi Kimura, Pedro L. C. Lima, David S. Pires, Matthew K. Waldor, Julia P. C. da Cunha   +5 more
doaj   +2 more sources

Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center [PDF]

Nature Communications
Frameshifts can be caused by specific combinations of tRNA and mRNA. The wildtype AGC-decoding E. coli tRNASer3 GCU has been shown to induce −1 ribosomal frameshifting on GCA alanine codons, and proposed to read a two-base codon instead of a canonical ...
Shruthi Krishnaswamy, Shirin Akbar, Daniel S. D. Larsson, Yang Chen, Maria Selmer   +4 more
doaj   +2 more sources

Anticodon sequence determines the impact of mistranslating tRNAAla variants

RNA Biology, 2023
Transfer RNAs (tRNAs) maintain translation fidelity through accurate charging by their cognate aminoacyl-tRNA synthetase and codon:anticodon base pairing with the mRNA at the ribosome. Mistranslation occurs when an amino acid not specified by the genetic
Ecaterina Cozma, Megha Rao, Madison Dusick, Julie Genereaux, Ricard A. Rodriguez-Mias, Judit Villén, Christopher J. Brandl, Matthew D. Berg   +7 more
doaj   +1 more source

Examining the Gm18 and mG Modification Positions in tRNA Sequences [PDF]

Genomics & Informatics, 2014
The tRNA structure contains conserved modifications that are responsible for its stability and are involved in the initiation and accuracy of the translation process. tRNA modification enzymes are prevalent in bacteria, archaea, and eukaryotes. tRNA Gm18
Mayavan Subramanian, Thangavelu Srinivasan, Dorairaj Sudarsanam   +2 more
doaj   +1 more source

Overview of tRNA Modifications in Chloroplasts

Microorganisms, 2022
The chloroplast is a promising platform for biotechnological innovation due to its compact translation machinery. Nucleotide modifications within a minimal set of tRNAs modulate codon–anticodon interactions that are crucial for translation efficiency ...
Maxime Fages-Lartaud, Martin Frank Hohmann-Marriott   +1 more
doaj   +1 more source

Anticodon-anticodon interactions in solution

Journal of Molecular Biology, 1985
Anticodon-anticodon pairing of complementary tRNA’s has been studied by fluorescence temperature jump measurements in the presence of different ligands as an approach for the evaluation of ligand binding to tRNA. This procedure is particularly useful for ligands which do not show spectroscopic changes upon binding, but affect the pairing potential of ...
Pascale Romby, Richard Giegé, Claude Houssier, Henri Grosjean   +3 more
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Mutation and selection on the wobble nucleotide in tRNA anticodons in marine bivalve mitochondrial genomes. [PDF]

PLoS ONE, 2011
BACKGROUND: Animal mitochondrial genomes typically encode one tRNA for each synonymous codon family, so that each tRNA anticodon essentially has to wobble to recognize two or four synonymous codons. Several factors have been hypothesized to determine the
Hong Yu, Qi Li
doaj   +1 more source

Phylogeny and evolution of chloroplast tRNAs in Adoxaceae

Ecology and Evolution, 2021
Chloroplasts are semiautonomous organelles found in photosynthetic plants. The major functions of chloroplasts include photosynthesis and carbon fixation, which are mainly regulated by its circular genomes. In the highly conserved chloroplast genome, the
Qiu‐Yi Zhong, Xiao‐Gang Fu, Ting‐Ting Zhang, Tong Zhou, Ming Yue, Jian‐Ni Liu, Zhong‐Hu Li   +6 more
doaj   +1 more source