Results 111 to 120 of about 31,015 (230)
Engineered transfer RNAs for suppression of premature termination codons
Nature Communications, 2019 Premature termination codon suppression therapy could be used to treat a range of genetic disorders. Here the authors present a high-throughput cell-based assay to identify anticodon engineered tRNAs with high suppression activity.
John D. Lueck +10 more
doaj +1 more source
The Triplet Genetic Code had a Doublet Predecessor
, 2004 Information theoretic analysis of genetic languages indicates that the naturally occurring 20 amino acids and the triplet genetic code arose by duplication of 10 amino acids of class-II and a doublet genetic code having codons NNY and anticodons ...
Patel, Apoorva
core
5\u27-Terminal nucleotide variations in human cytoplasmic tRNAHisGUG and its 5\u27-halves. [PDF]
, 2017 Transfer RNAs (tRNAs) are fundamental adapter components of translational machinery. tRNAs can further serve as a source of tRNA-derived noncoding RNAs that play important roles in various biological processes beyond translation.
Kirino, Yohei, Shigematsu, Megumi
core +1 more source
Genes & Development, 2004 The 40S subunit in 48S complexes formed at the initiation codon of mRNA is bound to eukaryotic initiation factor (eIF) 3, eIF1, eIF1A, and an eIF2/GTP/Met-tRNAi(Met) ternary complex and can therefore not join a 60S subunit directly to form an 80S ...
A. Unbehaun +3 more
semanticscholar +1 more source
PLoS Genetics, 2014 Identifying the genetic basis for mitochondrial diseases is technically challenging given the size of the mitochondrial proteome and the heterogeneity of disease presentations.
John W Yarham +17 more
doaj +1 more source
Application of a periodic table for the genetic code to influenza A/H3N2 virus [PDF]
, 2007 If biologists can utilize a table to have access to biological phenomena in the manner analogous to the periodic table for chemical elements, they may get hold of a directing post in life science.
Susumu Morimoto
core +1 more source
Nucleic Acids Research, 2009 Mitochondrial (mt) tRNAMet has the unusual modified nucleotide 5-formylcytidine (f5C) in the first position of the anticodon. This tRNA must translate both AUG and AUA as methionine.
C. Takemoto +5 more
semanticscholar +1 more source
Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code
Biology Direct, 2008 Background Transfer RNA (tRNA) is the means by which the cell translates DNA sequence into protein according to the rules of the genetic code. A credible proposition is that tRNA was formed from the duplication of an RNA hairpin half the length of the ...
Tate Warren P, Bernhardt Harold S
doaj +1 more source
Towards Understanding the Origin of Genetic Languages
, 2008 Molecular biology is a nanotechnology that works--it has worked for billions of years and in an amazing variety of circumstances. At its core is a system for acquiring, processing and communicating information that is universal, from viruses and bacteria
Patel, Apoorva D.
core +1 more source
BMC Evolutionary Biology, 2011 Background The Hemichordata comprises solitary-living Enteropneusta and colonial-living Pterobranchia, sharing morphological features with both Chordata and Echinodermata.
Stadler Peter F +5 more
doaj +1 more source