Results 11 to 20 of about 31,015 (230)
eLife, 2020 Modifications in the tRNA anticodon loop, adjacent to the three-nucleotide anticodon, influence translation fidelity by stabilizing the tRNA to allow for accurate reading of the mRNA genetic code.
Eric D Hoffer +6 more
doaj +2 more sources
Phage tRNAs evade tRNA-targeting host defenses through anticodon loop mutations
eLife, 2023 Transfer RNAs (tRNAs) in bacteriophage genomes are widespread across bacterial host genera, but their exact function has remained unclear for more than 50 years.
Daan F van den Berg +3 more
doaj +2 more sources
Nature Communications, 2018 The recognition of the mRNA codon by the tRNA anticodon is crucial for protein synthesis. Here the authors introduce non-standard nucleotides in bacterial and eukaryotic mRNA to reveal the minimal hydrogen bond requirement of codon-anticodon interaction ...
Thomas Philipp Hoernes +15 more
doaj +2 more sources
Factors That Shape Eukaryotic tRNAomes: Processing, Modification and Anticodon–Codon Use
Biomolecules, 2017 Transfer RNAs (tRNAs) contain sequence diversity beyond their anticodons and the large variety of nucleotide modifications found in all kingdoms of life.
Richard J. Maraia +1 more
doaj +2 more sources
PLoS Biology, 2019 Aminoacyl-tRNA synthetases (aaRSs) are well studied for their role in binding and charging tRNAs with cognate amino acids. Recent RNA interactome studies had suggested that these enzymes can also bind polyadenylated RNAs.
Ofri Levi, Yoav Arava
doaj +2 more sources
Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway. [PDF]
PLoS Genetics, 2018 Modification defects in the tRNA anticodon loop often impair yeast growth and cause human disease. In the budding yeast Saccharomyces cerevisiae and the phylogenetically distant fission yeast Schizosaccharomyces pombe, trm7Δ mutants grow poorly due to ...
Lu Han +3 more
doaj +2 more sources
tRNA anticodon shifts in eukaryotic genomes [PDF]
RNA, 2014 Embedded in the sequence of each transfer RNA are elements that promote specific interactions with its cognate aminoacyl tRNA-synthetase. Although many such “identity elements” are known, their detection is difficult since they rely on unique structural signatures and the combinatorial action of multiple elements spread throughout the tRNA molecule ...
Rogers, Hubert H., Griffiths-Jones, Sam
openaire +4 more sources
A Minimum Principle in Codon-Anticodon Interaction [PDF]
Biosystems, 2011 Imposing a minimum principle in the framework of the so called crystal basis model of the genetic code, we determine the structure of the minimum set of anticodons which allows the translational-transcription for animal mitochondrial code.
Sciarrino, A., Sorba, P.
core +8 more sources
An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting [PDF]
Nature CommunicationsRNA post-transcriptional modifications act by stabilizing the functional conformations of RNA. While their role in messenger RNA (mRNA) decoding is well established, it is less clear how transfer RNA (tRNA) modifications outside the anticodon contribute ...
Evelyn M. Kimbrough +9 more
doaj +2 more sources
Scientific Reports, 2023 The chloroplast genome of 5959 species was analyzed to construct the anticodon table of the chloroplast genome. Analysis of the chloroplast transfer ribonucleic acid (tRNA) revealed the presence of a putative quadruplet anticodon containing tRNAs in the ...
Tapan Kumar Mohanta +2 more
doaj +3 more sources