Results 21 to 30 of about 31,015 (230)

Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center [PDF]

Nature Communications
Frameshifts can be caused by specific combinations of tRNA and mRNA. The wildtype AGC-decoding E. coli tRNASer3 GCU has been shown to induce −1 ribosomal frameshifting on GCA alanine codons, and proposed to read a two-base codon instead of a canonical ...
Shruthi Krishnaswamy, Shirin Akbar, Daniel S. D. Larsson, Yang Chen, Maria Selmer   +4 more
doaj   +2 more sources

Integrating tRNA gene epigenomics and expression with codon usage unravels an intricate connection with translatome dynamics in Trypanosoma cruzi [PDF]

mBio
Codon usage bias impacts protein expression across all kingdoms of life, including trypanosomatids. These protozoa, such as the Trypanosoma cruzi, primarily regulate their protein-coding genes through posttranscriptional mechanisms.
Herbert G. S. Silva, Satoshi Kimura, Pedro L. C. Lima, David S. Pires, Matthew K. Waldor, Julia P. C. da Cunha   +5 more
doaj   +2 more sources

tRNA anticodon cleavage by target-activated CRISPR-Cas13a effector

bioRxiv, 2021
Type VI CRISPR-Cas systems are the only CRISPR variety that cleaves exclusively RNA1,2. In addition to the CRISPR RNA (crRNA)-guided, sequence-specific binding and cleavage of target RNAs, such as phage transcripts, the type VI effector, Cas13, causes ...
Ishita Jain, Matvey Kolesnik, L. Minakhin, N. Morozova, A. Shiriaeva, A. Kirillov, Sofia Medvedeva, K. Kuznedelov, S. Borukhov, K. Makarova, E. Koonin, K. Severinov, E. Semenova   +12 more
semanticscholar   +1 more source

Anticodon sequence determines the impact of mistranslating tRNAAla variants

RNA Biology, 2023
Transfer RNAs (tRNAs) maintain translation fidelity through accurate charging by their cognate aminoacyl-tRNA synthetase and codon:anticodon base pairing with the mRNA at the ribosome. Mistranslation occurs when an amino acid not specified by the genetic
Ecaterina Cozma, Megha Rao, Madison Dusick, Julie Genereaux, Ricard A. Rodriguez-Mias, Judit Villén, Christopher J. Brandl, Matthew D. Berg   +7 more
doaj   +1 more source

Examining the Gm18 and mG Modification Positions in tRNA Sequences [PDF]

Genomics & Informatics, 2014
The tRNA structure contains conserved modifications that are responsible for its stability and are involved in the initiation and accuracy of the translation process. tRNA modification enzymes are prevalent in bacteria, archaea, and eukaryotes. tRNA Gm18
Mayavan Subramanian, Thangavelu Srinivasan, Dorairaj Sudarsanam   +2 more
doaj   +1 more source

Overview of tRNA Modifications in Chloroplasts

Microorganisms, 2022
The chloroplast is a promising platform for biotechnological innovation due to its compact translation machinery. Nucleotide modifications within a minimal set of tRNAs modulate codon–anticodon interactions that are crucial for translation efficiency ...
Maxime Fages-Lartaud, Martin Frank Hohmann-Marriott   +1 more
doaj   +1 more source

Anticodon-anticodon interactions in solution

Journal of Molecular Biology, 1985
Anticodon-anticodon pairing of complementary tRNA’s has been studied by fluorescence temperature jump measurements in the presence of different ligands as an approach for the evaluation of ligand binding to tRNA. This procedure is particularly useful for ligands which do not show spectroscopic changes upon binding, but affect the pairing potential of ...
Pascale Romby, Richard Giegé, Claude Houssier, Henri Grosjean   +3 more
  +7 more sources

Mutation and selection on the wobble nucleotide in tRNA anticodons in marine bivalve mitochondrial genomes. [PDF]

PLoS ONE, 2011
BACKGROUND: Animal mitochondrial genomes typically encode one tRNA for each synonymous codon family, so that each tRNA anticodon essentially has to wobble to recognize two or four synonymous codons. Several factors have been hypothesized to determine the
Hong Yu, Qi Li
doaj   +1 more source

Phylogeny and evolution of chloroplast tRNAs in Adoxaceae

Ecology and Evolution, 2021
Chloroplasts are semiautonomous organelles found in photosynthetic plants. The major functions of chloroplasts include photosynthesis and carbon fixation, which are mainly regulated by its circular genomes. In the highly conserved chloroplast genome, the
Qiu‐Yi Zhong, Xiao‐Gang Fu, Ting‐Ting Zhang, Tong Zhou, Ming Yue, Jian‐Ni Liu, Zhong‐Hu Li   +6 more
doaj   +1 more source

Biophysical Interactions Underpin the Emergence of Information in the Genetic Code

Life, 2023
The genetic code conceals a ‘code within the codons’, which hints at biophysical interactions between amino acids and their cognate nucleotides. Yet, research over decades has failed to corroborate systematic biophysical interactions across the code ...
Aaron Halpern, Lilly R. Bartsch, Kaan Ibrahim, Stuart A. Harrison, Minkoo Ahn, John Christodoulou, Nick Lane   +6 more
doaj   +1 more source