Results 31 to 40 of about 31,015 (230)
Epigenomes, 2020 First identified 20 years ago as an RNA polymerase II-associated putative histone acetyltransferase, the conserved Elongator complex has since been recognized as the central player of a complex, regulated, and biologically relevant epitranscriptomic ...
Damien Hermand
doaj +1 more source
Conflict between translation initiation and elongation in vertebrate mitochondrial genomes. [PDF]
PLoS ONE, 2007 The strand-biased mutation spectrum in vertebrate mitochondrial genomes results in an AC-rich L-strand and a GT-rich H-strand. Because the L-strand is the sense strand of 12 protein-coding genes out of the 13, the third codon position is overall strongly
Xuhua Xia +4 more
doaj +1 more source
Chronic Progressive External Ophthalmoplegia Is Associated with a Novel Mutation in the Mitochondrial tRNA(Asn) Gene [PDF]
, 1994 Chronic progressive external ophthalmoplegia (CPEO) is caused by a decreased oxidative phosphorylation (OXPHOS) activity due to large-scale deletions of the mitochondrial genome in 50 % of the patients.
Kadenbach, B. +5 more
core +1 more source
The biogenesis pathway of tRNA-derived piRNAs in Bombyx germ cells. [PDF]
, 2017 Transfer RNAs (tRNAs) function in translational machinery and further serves as a source of short non-coding RNAs (ncRNAs). tRNA-derived ncRNAs show differential expression profiles and play roles in many biological processes beyond translation ...
Honda, Shozo +5 more
core +2 more sources
Codon Bias Patterns of $E.coli$'s Interacting Proteins [PDF]
, 2015 Synonymous codons, i.e., DNA nucleotide triplets coding for the same amino acid, are used differently across the variety of living organisms. The biological meaning of this phenomenon, known as codon usage bias, is still controversial.
Cimini, Giulio +4 more
core +8 more sources
Functional plasticity of antibacterial EndoU toxins. [PDF]
, 2018 Bacteria use several different secretion systems to deliver toxic EndoU ribonucleases into neighboring cells. Here, we present the first structure of a prokaryotic EndoU toxin in complex with its cognate immunity protein.
Eschenfeldt, William H +11 more
core +1 more source
A rationale for tRNA modification circuits in the anticodon loop
RNA: A publication of the RNA Society, 2018 The numerous post-transcriptional modifications of tRNA play a crucial role in tRNA function. While most modifications are introduced to tRNA independently, several sets of modifications are found to be interconnected such that the presence of one set of
Lu Han, E. Phizicky
semanticscholar +1 more source
High-affinity recognition of specific tRNAs by an mRNA anticodon-binding groove
Nature Structural & Molecular Biology, 2019 T-box riboswitches are modular bacterial noncoding RNAs that sense and regulate amino acid availability through direct interactions with tRNAs. Between the 5′ anticodon-binding stem I domain and the 3′ amino acid sensing domains of most T-boxes lies the ...
K. Suddala, Jinwei Zhang
semanticscholar +1 more source
Journal of Biological Chemistry, 2019 Modification of anticodon nucleotides allows tRNAs to decode multiple codons, expanding the genetic code. Additionally, modifications located in the anticodon loop, but outside the anticodon itself, stabilize tRNA–codon interactions, increasing decoding ...
Ha An Nguyen, E. Hoffer, C. Dunham
semanticscholar +1 more source
RNA: A publication of the RNA Society, 2017 The 3-methylcytidine (m3C) modification is ubiquitous in eukaryotic tRNA, widely found at C32 in the anticodon loop of tRNAThr, tRNASer, and some tRNAArg species, as well as in the variable loop (V-loop) of certain tRNASer species.
Lu Han +3 more
semanticscholar +1 more source