Results 41 to 50 of about 31,015 (230)
Solving the riddle of codon usage preferences: a test for translational selection [PDF]
, 1998 Translational selection is responsible for the unequal usage of synonymous codons in protein coding genes in a wide variety of organisms. It is one of the most subtle and pervasive forces of molecular evolution, yet, establishing the underlying causes ...
A Kaminskii +17 more
core +3 more sources
eLife, 2017 Messenger RNA function is controlled by the 3' poly(A) tail (PAT) and poly(A)-binding protein (PABP). La-related protein-4 (LARP4) binds poly(A) and PABP.
Sandy Mattijssen +6 more
doaj +1 more source
eLife, 2022 Engineering transfer RNAs to read codons consisting of four bases requires changes in tRNA that go beyond the anticodon sequence.
Tarana Siddika +2 more
doaj +1 more source
An Unnatural Amino Acid-Regulated Growth Controller Based on Informational Disturbance
Life, 2021 We designed a novel growth controller regulated by feeding of an unnatural amino acid, Nε-benzyloxycarbonyl-l-lysine (ZK), using a specific incorporation system at a sense codon. This system is constructed by a pair of modified pyrrolisyl-tRNA synthetase
Yusuke Kato
doaj +1 more source
The Genetic Code as a Periodic Table: Algebraic Aspects [PDF]
, 2000 The systematics of indices of physico-chemical properties of codons and amino acids across the genetic code are examined. Using a simple numerical labelling scheme for nucleic acid bases, data can be fitted as low-order polynomials of the 6 coordinates ...
Bashford +30 more
core +3 more sources
The ribosome prohibits the G•U wobble geometry at the first position of the codon–anticodon helix
Nucleic Acids Research, 2016 Precise conversion of genetic information into proteins is essential to cellular health. However, a margin of error exists and is at its highest on the stage of translation of mRNA by the ribosome. Here we present three crystal structures of 70S ribosome
A. Rozov +3 more
semanticscholar +1 more source
Ordering events in a developing genetic code
RNA BiologyPreexisting partial genetic codes can fuse to evolve towards the complete Standard Genetic Code (SGC). Such code fusion provides a path of ‘least selection’, readily generating precursor codes that resemble the SGC.
Michael Yarus
doaj +1 more source
Symmetry and Minimum Principle at the Basis of the Genetic Code
, 2017 The importance of the notion of symmetry in physics is well established: could it also be the case for the genetic code? In this spirit, a model for the Genetic Code based on continuous symmetries and entitled the "Crystal Basis Model" has been proposed ...
Sciarrino, A., Sorba, P.
core +1 more source
Selective gene expression maintains human tRNA anticodon pools during differentiation
Nature Cell BiologyTransfer RNAs are essential for translating genetic information into proteins. The human genome contains hundreds of predicted tRNA genes, many in multiple copies. How their expression is regulated to control tRNA repertoires is unknown. Here we combined
Lexi Gao +6 more
semanticscholar +1 more source
tRNA anticodon loop modifications ensure protein homeostasis and cell morphogenesis in yeast
Nucleic Acids Research, 2016 Using budding yeast, we investigated a negative interaction network among genes for tRNA modifications previously implicated in anticodon-codon interaction: 5-methoxy-carbonyl-methyl-2-thio-uridine (mcm5s2U34: ELP3, URM1), pseudouridine (Ψ38/39: DEG1 ...
Roland Klassen +5 more
semanticscholar +1 more source