Results 71 to 80 of about 31,015 (230)
Chemistry – A European Journal, EarlyView.One‐step, highly efficient, and scalable synthesis of acp3U phosphoramidite is described, as well as a new alternative synthesis of cmnm5U phosphoramidite from a highly versatile intermediate. Latter could be scaled‐up, split, and aliquots turned simultaneously into cmnm5U, nm5U, and mnm5U.
Ewa Mejdr +3 more
wiley +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Cell Reports, 2014 Summary: tRNA restriction by anticodon nucleases underlies cellular stress responses and self-nonself discrimination in a wide range of taxa. Anticodon breakage inhibits protein synthesis, which, in turn, results in growth arrest or cell death.
Anupam K. Chakravarty +3 more
doaj +1 more source
Crystal structure analysis reveals functional flexibility in the selenocysteine-specific tRNA from mouse. [PDF]
PLoS ONE, 2011 Selenocysteine tRNAs (tRNA(Sec)) exhibit a number of unique identity elements that are recognized specifically by proteins of the selenocysteine biosynthetic pathways and decoding machineries.
Oleg M Ganichkin +2 more
doaj +1 more source
Molecular Dynamics Simulations Suggest a Non-Doublet Decoding Model of −1 Frameshifting by tRNASer3
Biomolecules, 2019 In-frame decoding in the ribosome occurs through canonical or wobble Watson−Crick pairing of three mRNA codon bases (a triplet) with a triplet of anticodon bases in tRNA.
Thomas Caulfield +3 more
doaj +1 more source
Selection of start codon during mRNA scanning in eukaryotic translation initiation
Communications Biology, 2022 Molecular simulations of start codon selection by the eukaryotic ribosome during mRNA scanning provide further insight into high speed of scanning and how initiation factors contribute toward codon-anticodon-ribosome network stability.
Ipsita Basu +4 more
doaj +1 more source
Role of the particle's stepping cycle in an asymmetric exclusion process: A model of mRNA translation [PDF]
, 2010 Messenger RNA translation is often studied by means of statistical-mechanical models based on the Asymmetric Simple Exclusion Process (ASEP), which considers hopping particles (the ribosomes) on a lattice (the polynucleotide chain).
Ciandrini, L. +2 more
core +3 more sources
Loss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling
PLoS Genetics, 2013 Transfer RNA (tRNA) modifications enhance the efficiency, specificity and fidelity of translation in all organisms. The anticodon modification mcm5s2U34 is required for normal growth and stress resistance in yeast; mutants lacking this modification have ...
Boris Zinshteyn, Wendy V. Gilbert
semanticscholar +1 more source
The FEBS Journal, EarlyView.The eukaryote‐specific N‐terminal domain (NTD) of eS31 uses two distinct strategies to maintain translation fidelity. During elongation, a positively charged “hotspot” fine‐tunes the selection of incoming aa‐tRNA. During termination, the entire NTD acts as a structural scaffold to ensure the correct positioning of the release factor eRF1.
Qingxuan Gao +3 more
wiley +1 more source
Role of Pseudouridine Formation by Deg1 for Functionality of Two Glutamine Isoacceptor tRNAs
Biomolecules, 2017 Loss of Deg1/Pus3 and concomitant elimination of pseudouridine in tRNA at positions 38 and 39 (ψ38/39) was shown to specifically impair the function of tRNAGlnUUG under conditions of temperature-induced down-regulation of wobble uridine thiolation in ...
Roland Klassen, Raffael Schaffrath
doaj +1 more source