Results 1 to 10 of about 4,550 (183)

Quality Assessment of Therapeutic Drug Monitoring Assays of Therapeutic Antibodies Across Europe: An Update. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Immune mediated inflammatory diseases (IMIDs) are common, chronic, inflammatory diseases. There has been an expansion of monoclonal antibodies to treat the disease. However, the response is not universal; reasons for non‐response may include suboptimal drug concentrations for which therapeutic drug monitoring (TDM) may lead to improved ...
Bluett J, Rumano M, Martínez Becerra MJ, Loeff F, Itik M, Ternant D, Desvignes C, Mulleman D, Skrede S.   +8 more
europepmc   +2 more sources

Recherche des anticorps antiplaquettaires par cytométrie en flux, chez les patients présentant un purpura thrombopénique immunologique [PDF]

Batna Journal of Medical Sciences, 2021
En raison de la non disponibilité d’un test biologique qui confirme le diagnostic du PTI « « purpura thrombopénique immunologique », ce dernier se pose par élimination de toutes les autres causes secondaires d’une thrombopénie.
Raouf Zouitene, Mohamed Brahimi
doaj   +1 more source

The Proteolytic Cleavage of Therapeutic Monoclonal Antibody Hinge Region: More Than a Matter of Subclass

Frontiers in Immunology, 2020
The hinge region of immunoglobulin G (IgG) is involved in C1q and FcγRIIIA-expressing natural killer (NK) cell recruitment. Both heavy chains (HCs) of the hinge region can be cleaved sequentially by several proteases of the tumor/inflammatory/infectious ...
Quentin Deveuve, Laurie Lajoie, Benjamin Barrault, Gilles Thibault, Gilles Thibault   +4 more
doaj   +1 more source

Efficacy and safety of intravenous bevacizumab on severe bleeding associated with hemorrhagic hereditary telangiectasia: A national, randomized multicenter trial

Journal of Internal Medicine, Volume 294, Issue 6, Page 761-774, December 2023., 2023
Abstract Background Bevacizumab—a humanized monoclonal antibody—has been widely used to treat patients with hereditary hemorrhagic telangiectasia (HHT), but no randomized trial has yet been conducted. Methods This study is a double‐blind multicenter randomized phase 2 trial with a 1:1 active‐treatment‐to‐placebo ratio. We included patients over the age
Sophie Dupuis‐Girod, Sophie Rivière, Christian Lavigne, Anne‐Emmanuelle Fargeton, Brigitte Gilbert‐Dussardier, Vincent Grobost, Vanessa Leguy‐Seguin, Hélène Maillard, Shirine Mohamed, Evelyne Decullier, Adeline Roux, Lorraine Bernard, Jean‐Christophe Saurin, Nicolas Saroul, Frédéric Faure, Cesar Cartier, Romain Altwegg, Laurent Laccourreye, Frédéric Oberti, Marjolaine Beaudoin, Carole Dhelens, Céline Desvignes, Nicolas Azzopardi, Gilles Paintaud, Ruben Hermann, Thierry Chinet   +25 more
wiley   +1 more source

Cytokine transcriptome profiling in acute experimental canine atopic dermatitis skin lesions after IL‐31 inhibition with lokivetmab

Veterinary Dermatology, Volume 34, Issue 4, Page 327-338, August 2023., 2023
Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki, Natalie Crawford, Jordan M. Eder, Andrea J. Gonzales, Thierry Olivry   +4 more
wiley   +1 more source

Long Non‐Coding RNA HOTAIR Promotes Human Osteosarcoma Proliferation, Migration through Activation of the Wnt/b‐Catenin Signaling Pathway

Journal of Oncology, Volume 2023, Issue 1, 2023., 2023
LncRNA HOTAIR exhibited different effects in human cancers. However, the role of HOTAIR was not reported in osteosarcoma. This study aimed to explore the function of HOTAIR in osteosarcoma. Firstly, we examined HOTAIR expression in breast cancer tissues by the RT‐qPCR assay and examined HOTAIR protein expression via immunocytochemistry, to chemical ...
Hang Li, Shijian Fu, Wenbo Wang, Muhammad Muddassir Ali   +3 more
wiley   +1 more source

Hsa_circ_0001666 suppresses the progression of colorectal cancer through the miR‐576‐5p/PCDH10 axis

Clinical and Translational Medicine, Volume 11, Issue 11, November 2021., 2021
This study demonstrates that hsa_circ_0001666 suppresses the progression of colorectal cancer. Hsa_circ_0001666 can regulate the PCDH10 expression by competitively interacting with miR‐576‐5p. Hsa_circ_0001666 inhibits the Wnt/β‐catenin signalling pathway.
Jiahui Zhou, Lu Wang, Qingyang Sun, Ranran Chen, Chuan Zhang, Peng Yang, Yuqian Tan, Chaofan Peng, Tuo Wang, Chi Jin, Jiangzhou Ji, Kangpeng Jin, Yueming Sun   +12 more
wiley   +1 more source

A masked, randomised clinical trial evaluating the efficacy and safety of lokivetmab compared to saline control in client‐owned dogs with allergic dermatitis

Veterinary Dermatology, Volume 32, Issue 5, Page 477-e131, October 2021., 2021
Background – Interleukin (IL)‐31 is an important mediator in canine atopic dermatitis (cAD) and also may be dysregulated in other allergic diseases. Hypothesis/Objectives – To demonstrate the efficacy and safety of lokivetmab (canine anti‐IL‐31 monoclonal antibody) for treatment of pruritus associated with allergic dermatitis in dogs.
Leen Van Brussel, Hilde Moyaert, Monica Escalada, Sean P. Mahabir, Michael R. Stegemann   +4 more
wiley   +1 more source

Immunopathogenesis of the feline atopic syndrome

Veterinary Dermatology, Volume 32, Issue 1, Page 13-e4, February 2021., 2021
Résumé Contexte Les maladies félines supposées d’origine allergique avec des phénotypes cliniques semblables, peuvent avoir de nombreuses pathogénies différentes sous jacentes. Le phénotype clinque, l’étiologie précise et l’immunopathogénie sous jacente doivent tous être considérés si des avancées veulent être faites dans ces domaines négligés de la ...
Richard Halliwell, Frane Banovic, Ralf S. Mueller, Thierry Olivry   +3 more
wiley   +1 more source

Guide pratique à l’intention des laboratoires cliniques pour les tests de sérologie du SRAS-CoV-2

Canada Communicable Disease Report, 2021
Le répertoire des tests de diagnostic disponibles du coronavirus du syndrome respiratoire aigu sévère 2 (SRAS-CoV-2) évolue rapidement. Bien que les tests sérologiques aient une capacité de diagnostic limitée concernant l’infection aiguë, leur rôle dans ...
Carmen Charlton, Jamil Kanji, Vanessa Tran, Julianne Kus, Jonathan Gubbay, Carla Osiowy, Jason Robinson, Inna Sekirov, Michael Drebot, Todd Hatchette, Derek Stein, Nadia El-Gabalawy, Amanda Lang, Lei Jiao, Paul Levett, Heidi Wood, Christian Therrien, L Robbin Lindsay, Muhammad Morshed, Jessica Forbes, Antonia Dibernardo   +20 more
doaj   +1 more source