Results 11 to 20 of about 12,529 (195)

Cytokine transcriptome profiling in acute experimental canine atopic dermatitis skin lesions after IL‐31 inhibition with lokivetmab

Veterinary Dermatology, Volume 34, Issue 4, Page 327-338, August 2023., 2023
Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki, Natalie Crawford, Jordan M. Eder, Andrea J. Gonzales, Thierry Olivry   +4 more
wiley   +1 more source

A masked, randomised clinical trial evaluating the efficacy and safety of lokivetmab compared to saline control in client‐owned dogs with allergic dermatitis

Veterinary Dermatology, Volume 32, Issue 5, Page 477-e131, October 2021., 2021
Background – Interleukin (IL)‐31 is an important mediator in canine atopic dermatitis (cAD) and also may be dysregulated in other allergic diseases. Hypothesis/Objectives – To demonstrate the efficacy and safety of lokivetmab (canine anti‐IL‐31 monoclonal antibody) for treatment of pruritus associated with allergic dermatitis in dogs.
Leen Van Brussel, Hilde Moyaert, Monica Escalada, Sean P. Mahabir, Michael R. Stegemann   +4 more
wiley   +1 more source

Detection and Inhibition of IgE for cross‐reactive carbohydrate determinants evident in an enzyme‐linked immunosorbent assay for detection of allergen‐specific IgE in the sera of dogs and cats

Veterinary Dermatology, Volume 31, Issue 6, Page 439-e116, December 2020., 2020
Background It has been demonstrated recently that immunoglobulin (Ig)E specific for cross‐reactive carbohydrate determinants (CCD) is present in the serum of allergen‐sensitized dogs and cats, and that these CCD‐specific antibodies might confound serological testing. Hypothesis/Objective The objective was to document the prevalence of CCD detectable in
Kenneth W. Lee, Brennan H. McKinney, Karen D. Blankenship, Daniel O. Morris   +3 more
wiley   +1 more source

Discrepancies in the bilateral intradermal test and serum tests in atopic horses

Veterinary Dermatology, Volume 31, Issue 5, Page 390-e104, October 2020., 2020
Background – In equine atopic patients intradermal testing (IDT) and immunoglobulin (Ig)E serology are used frequently. There is little evidence regarding the reproducibility of the IDT and IgE serology in horses. Objectives – To compare the results of a simultaneously performed IDT on the left and right side of the neck in atopic horses, and to ...
Catharina M. M. van Damme, Jan van den Broek, Marianne M. Sloet van Oldruitenborgh‐Oosterbaan   +2 more
wiley   +1 more source

Use of monoclonal antibodies in cancer immunotherapy: types and mechanisms of action

Boletín Médico del Hospital Infantil de México, 2023
Immunotherapy is one of the most innovative treatments in the current field of oncology and consists of stimulating the immune system to eliminate tumoral cells.
Paola Damián-Blanco, Selene Ahuexoteco-Sánchez, Adrián A. Carbajal-Gallardo, Fredi C. Coctecon-Chávelas, Cynthia Rodríguez-Nava, Amalia Vences-Velázquez, Yolanda Medina-Flores, Olga Mata-Ruíz, Lourdes Lloret-Sánchez, Karen Cortés-Sarabia   +9 more
doaj   +1 more source

Anticuerpos monoclonales: aplicaciones en infectología

Diagnóstico, 2021
La terapia basada en anticuerpos pre formados, precede al uso de antibióticos, en enfermedades infecciosas. Se clasifican en anticuerpos monoclonales y policlonales, y pueden ser administradas previo al contacto con el agente infeccioso (pre exposición), o posterior al mismo (post exposición).
openaire   +1 more source

Endothelium capture‐based liver segment imaging using vascular endothelial growth factor receptor 2 in preclinical ex vivo models

BJS Open, Volume 4, Issue 2, Page 332-341, April 2020., 2020
Imaging of liver segments provides substantial information for surgeons when performing liver resection. The anti‐vascular endothelial growth factor receptor (VEGFR) 2 antibody ramucirumab conjugated with near‐infrared dye could visualize selected liver segments using an endothelial capture‐based approach in an isolated perfusion liver model.
D. Kyuno, B. Qian, W. Groß, M. Schäfer, E. Ryschich   +4 more
wiley   +1 more source

Terapia con anticuerpos monoclonales en Cardiología y Medicina Interna

Revista Colombiana de Cardiología, 2016
La terapia biológica basada en anticuerpos monoclonales, constituyen una nueva herramienta terapéutica, que de la mano del desarrollo de la biología molecular permiten intervenir puntos claves en la etiopatogenia de la enfermedad, permitiendo una terapia
Christian David Adams-Sánchez, Gabriel Jaime Tobón-García   +1 more
doaj   +1 more source

Monoclonal antibodies. Basic features

Neurología (English Edition), 2011
Introduction: Monoclonal antibodies are a powerful tool in laboratory diagnosis and are increasingly used in the treatment of several diseases. Development: Antibody development and characterization has a long history and goes back to immunology itself ...
A. García Merino
doaj   +1 more source

Successful capture of Toxocara canis larva antigens from human serum samples

Parasites & Vectors, 2015
Background Toxocara canis is a nematode that parasitizes dogs, while humans are paratenic hosts. When humans are infected the migrating larvae damage the liver, lungs and even the nervous system.
Aarón Rodríguez-Caballero, Mario Noé Martínez-Gordillo, Yolanda Medina-Flores, María Edith Medina-Escutia, Antonio Meza-Lucas, Dolores Correa, Silvia Caballero-Salazar, Martha Ponce-Macotela   +7 more
doaj   +1 more source