Results 1 to 10 of about 396,509 (381)
Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?
Frontiers in Pharmacology, 2022 Dopamine and its receptors are currently recognized targets for the treatment of several neuropsychiatric disorders, including Parkinson’s disease, schizophrenia, some drug use addictions, as well as depression.
Fangyi Zhao +9 more
doaj +1 more source
European Psychiatry, 2022 One reason behind the failure to understand the neurobiological background of affective disorders and develop more effective treatments is their heterogeneity warranting identification of clinically meaningful endophenotypes.
X. Gonda +7 more
doaj +1 more source
Association of genetic variants of Glutamate Metabotropic Receptor 5 gene and state-anhedonia
European Psychiatry, 2022 Introduction Andedonia is one of the core symptoms of depression. It is known that in case of depressed individuals experiencing anhedonia, the classical antidepressants are often ineffective, thus investigation of this symptom would be essential ...
D. Török +6 more
doaj +1 more source
Translational Psychiatry, 2021 Although recently a large-sample GWASs identified significant loci in the background of depression, the heterogeneity of the depressive phenotype and the lack of accurate phenotyping hinders applicability of findings.
Xenia Gonda +11 more
doaj +1 more source
Epigenetic Mechanism of Early Life Stress-Induced Depression: Focus on the Neurotransmitter Systems
Frontiers in Cell and Developmental Biology, 2022 Depression has an alarmingly high prevalence worldwide. A growing body of evidence indicates that environmental factors significantly affect the neural development and function of the central nervous system and then induce psychiatric disorders.
Ziqian Cheng +7 more
doaj +1 more source
Frontiers in Psychiatry, 2021 The interplay between tuberculosis and depression has been problematic since the humoralists. Over the centuries similarities in disease management have transpired.
Martie Van Der Walt, Karen H. Keddy
doaj +1 more source
Behavioral and Developmental Changes in Brown Trout After Exposure to the Antidepressant Venlafaxine
Frontiers in Environmental Science, 2021 During the last decades, depression has been diagnosed in increasing numbers, accompanied by rising prescription rates of antidepressants. Concomitantly, these pharmaceuticals are frequently detected in surface waters. Serotonin and noradrenalin reuptake
Michael Ziegler +9 more
doaj +1 more source
Frontiers in Nutrition, 2022 Since the 1990s, the prevalence of mental illnesses, such as depression, has been increasing annually and has become a major burden on society. Due to the many side effects of antidepressant drugs, the development of a complementary therapy from natural ...
Ming-Yu Chou +15 more
doaj +1 more source
FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy
Microbiology Spectrum, 2022 Antibiotic resistance poses a significant hurdle in combating global public health crises, prompting the development of novel therapeutics. Strategies to enhance the intracellular killing of mycobacteria by targeting host defense mechanisms offer ...
Jia Wang +4 more
doaj +1 more source
Design, synthesis, molecular modelling and in vitro screening of monoamine oxidase inhibitory activities of novel quinazolyl hydrazine derivatives [PDF]
Royal Society Open Science, 2020 A new series of N'-substituted benzylidene-2-(4-oxo-2-phenyl-1,4-dihydroquinazolin-3(2H)-yl)acetohydrazide (5a–5h) has been synthesized, characterized by FT-IR, NMR spectroscopy and mass spectrometry and tested against human monoamine oxidase (MAO) A and
Adel Amer +6 more
doaj +1 more source