SSRN Electronic Journal, 2011 Antidepressants as a commodity have been remarkably little-studied by economists. This study shows in new data for 27 European countries that 8% of people (and 10% of those middle-aged) take antidepressants each year.
Blanchflower, David G. +1 more
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Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice [PDF]
, 2015 Poor micturition control may cause profound distress, because proper voiding is mandatory for an active social life. Micturition results from the subtle interplay of central and peripheral components.
Antonio, Caretta +6 more
core +16 more sources
Pharmacogenetics of Antidepressants [PDF]
Frontiers in Pharmacology, 2011 Up to 60% of depressed patients do not respond completely to antidepressants (ADs) and up to 30% do not respond at all. Genetic factors contribute for about 50% of the AD response. During the recent years the possible influence of a set of candidate genes as genetic predictors of AD response efficacy was investigated by us and others.
Crisafulli C +6 more
openaire +6 more sources
A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. [PDF]
, 2020 Predicting antidepressant response has been a clinical challenge for mood disorder. Although several genome-wide association studies have suggested a number of genetic variants to be associated with antidepressant response, the sample sizes are small and
Aitchison, Katherine J +14 more
core +2 more sources
Experimental pharmacological research regarding the antidepressant effect of associating doxepin and selegiline in normal mice [PDF]
, 2019 The severity and complexity of depression can vary widely among individuals, thus making single drug therapy ineffective in some cases. Taking this fact into account and using a mouse model, we set on investigating the possibility of obtaining a ...
Chiriță, Cornel +8 more
core +2 more sources
Neural correlates of emotion processing comparing antidepressants and exogenous oxytocin in postpartum depressed women: An exploratory study [PDF]
, 2019 Despite common use of antidepressants to treat postpartum depression, little is known about the impact of antidepressant use on postpartum brain activity.
Cheng, Hu +2 more
core +3 more sources
Pharmacology of Antidepressants [PDF]
Psychopathology, 1987 Presently in the United States, 21 compounds have been approved by the Food and Drug Administration as antidepressants. Two additional drugs marketed outside the United States as antidepressants have been approved for obsessive-compulsive disorder.
openaire +3 more sources
Fluoxetine: a case history of its discovery and preclinical development [PDF]
, 2014 Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N +20 more
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The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus [PDF]
, 2016 Indexación: Web of Science; Scopus.Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression.
Aguayo, F. +12 more
core +1 more source
Australian Prescriber, 2021 A biopsychosocial and lifestyle approach should be used when managing depression. Many patients seen in primary care do not require drug therapy Evidence-based treatments such as psychological therapies and antidepressant drugs are effective for depression.
Boyce, Philip, Ma, Cassandra
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