Results 1 to 10 of about 251,609 (285)

Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?

Frontiers in Pharmacology, 2022
Dopamine and its receptors are currently recognized targets for the treatment of several neuropsychiatric disorders, including Parkinson’s disease, schizophrenia, some drug use addictions, as well as depression.
Fangyi Zhao, Fangyi Zhao, Ziqian Cheng, Ziqian Cheng, Jingjing Piao, Jingjing Piao, Ranji Cui, Ranji Cui, Bingjin Li, Bingjin Li   +9 more
doaj   +1 more source

The Genetic Underpinnings of Affective Temperaments: Identifying Novel Risk Variants with a Whole Genome Analytical Approach

European Psychiatry, 2022
One reason behind the failure to understand the neurobiological background of affective disorders and develop more effective treatments is their heterogeneity warranting identification of clinically meaningful endophenotypes.
X. Gonda, N. Eszlari, D. Torok, Z. Gal, A. Millinghoffer, P. Antal, G. Juhasz, G. Bagdy   +7 more
doaj   +1 more source

Association of genetic variants of Glutamate Metabotropic Receptor 5 gene and state-anhedonia

European Psychiatry, 2022
Introduction Andedonia is one of the core symptoms of depression. It is known that in case of depressed individuals experiencing anhedonia, the classical antidepressants are often ineffective, thus investigation of this symptom would be essential ...
D. Török, X. Gonda, Z. Gal, N. Eszlari, G. Bagdy, G. Juhasz, P. Petschner   +6 more
doaj   +1 more source

Genetic underpinnings of affective temperaments: a pilot GWAS investigation identifies a new genome-wide significant SNP for anxious temperament in ADGRB3 gene

Translational Psychiatry, 2021
Although recently a large-sample GWASs identified significant loci in the background of depression, the heterogeneity of the depressive phenotype and the lack of accurate phenotyping hinders applicability of findings.
Xenia Gonda, Nora Eszlari, Dora Torok, Zsofia Gal, Janos Bokor, Andras Millinghoffer, Daniel Baksa, Peter Petschner, Peter Antal, Gerome Breen, Gabriella Juhasz, Gyorgy Bagdy   +11 more
doaj   +1 more source

Epigenetic Mechanism of Early Life Stress-Induced Depression: Focus on the Neurotransmitter Systems

Frontiers in Cell and Developmental Biology, 2022
Depression has an alarmingly high prevalence worldwide. A growing body of evidence indicates that environmental factors significantly affect the neural development and function of the central nervous system and then induce psychiatric disorders.
Ziqian Cheng, Ziqian Cheng, Jingyun Su, Jingyun Su, Kai Zhang, Huiyi Jiang, Bingjin Li, Bingjin Li   +7 more
doaj   +1 more source

Improvement of hedonic perception of odors as a marker of treatment response to escitalopram: olfactory changes through an open-label antidepressant trial [PDF]

Brazilian Journal of Psychiatry, 2023
Objectives: To assess olfactory functions (threshold, identification, and hedonic valence) of depressed subjects before and after an 8-week trial of escitalopram and compare the results of responders and nonresponders.
François Kazour, Boriana Atanasova, Thomas Desmidt, Valérie Gissot, Apolline Lefevre, Vincent Camus, Catherine Belzung, Wissam El-Hage   +7 more
doaj   +1 more source

Effectiveness of vortioxetine in patients with major depressive disorder and comorbid Alzheimer’s disease in routine clinical practice: An analysis of a post-marketing surveillance study in South Korea

Frontiers in Aging Neuroscience, 2023
BackgroundVortioxetine has demonstrated procognitive effects in patients with major depressive disorder (MDD). We assessed the effectiveness and safety of vortioxetine in a cohort of patients with MDD and comorbid Alzheimer’s disease participating in a ...
Eduardo Cumbo, Michael Adair, Daniel Oudin Åstrom, Michael Cronquist Christensen   +3 more
doaj   +1 more source

AM-251, A Cannabinoid Antagonist, Modifies the Dynamics of Sleep–Wake Cycles in Rats

Frontiers in Pharmacology, 2019
Study Objectives: (a) To describe the microarchitecture of wakefulness and sleep following administrations of 5- and 10-mg/kg AM-251 in rats. (b) To develop a new statistical method to follow bout-to-bout dynamics.Method: Wistar rats (n = 6) had been ...
Emese Bogáthy, Noémi Papp, Szilvia Vas, Szilvia Vas, Szilvia Vas, György Bagdy, György Bagdy, György Bagdy, György Bagdy, László Tóthfalusi   +9 more
doaj   +1 more source

Neural Predictors of the Antidepressant Placebo Response

Pharmaceuticals, 2019
The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates.
Danielle Rette, Erin McDonald, Dan V. Iosifescu, Katherine A. Collins   +3 more
doaj   +1 more source

Association between insight and internalized stigma and other clinical factors among patients with depression: A cross-sectional study

Indian Journal of Psychiatry, 2020
Background: Insight influences treatment adherence among patients with depression. These patients also experience considerable social and self-stigma. The relationship between insight and internalized stigma has been extensively studied among patients ...
Luke Sy-Cherng Woon, Siew Im Khoo, Azlin Baharudin, Marhani Midin   +3 more
doaj   +1 more source