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Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?
Frontiers in Pharmacology, 2022 Dopamine and its receptors are currently recognized targets for the treatment of several neuropsychiatric disorders, including Parkinson’s disease, schizophrenia, some drug use addictions, as well as depression.
Fangyi Zhao +9 more
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European Psychiatry, 2022 One reason behind the failure to understand the neurobiological background of affective disorders and develop more effective treatments is their heterogeneity warranting identification of clinically meaningful endophenotypes.
X. Gonda +7 more
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Association of genetic variants of Glutamate Metabotropic Receptor 5 gene and state-anhedonia
European Psychiatry, 2022 Introduction Andedonia is one of the core symptoms of depression. It is known that in case of depressed individuals experiencing anhedonia, the classical antidepressants are often ineffective, thus investigation of this symptom would be essential ...
D. Török +6 more
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Translational Psychiatry, 2021 Although recently a large-sample GWASs identified significant loci in the background of depression, the heterogeneity of the depressive phenotype and the lack of accurate phenotyping hinders applicability of findings.
Xenia Gonda +11 more
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Epigenetic Mechanism of Early Life Stress-Induced Depression: Focus on the Neurotransmitter Systems
Frontiers in Cell and Developmental Biology, 2022 Depression has an alarmingly high prevalence worldwide. A growing body of evidence indicates that environmental factors significantly affect the neural development and function of the central nervous system and then induce psychiatric disorders.
Ziqian Cheng +7 more
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Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Psychedelic compounds, such as psilocybin, have beneficial actions in several psychiatric diseases. They also produce strong alterations of consciousness, which may be a barrier to their widespread use.
Natalie Hesselgrave +4 more
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Frontiers in Psychiatry, 2021 The interplay between tuberculosis and depression has been problematic since the humoralists. Over the centuries similarities in disease management have transpired.
Martie Van Der Walt, Karen H. Keddy
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Behavioral and Developmental Changes in Brown Trout After Exposure to the Antidepressant Venlafaxine
Frontiers in Environmental Science, 2021 During the last decades, depression has been diagnosed in increasing numbers, accompanied by rising prescription rates of antidepressants. Concomitantly, these pharmaceuticals are frequently detected in surface waters. Serotonin and noradrenalin reuptake
Michael Ziegler +9 more
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Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor
Molecular Psychiatry, 2021 The discovery of robust antidepressant actions exerted by the N -methyl-D-aspartate receptor (NMDAR) antagonist ( R,S )-ketamine has been a crucial breakthrough in mood disorder research.
Yan Wei, Lijia Chang, K. Hashimoto
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Frontiers in Nutrition, 2022 Since the 1990s, the prevalence of mental illnesses, such as depression, has been increasing annually and has become a major burden on society. Due to the many side effects of antidepressant drugs, the development of a complementary therapy from natural ...
Ming-Yu Chou +15 more
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