Results 1 to 10 of about 412,505 (386)

Knowledge Gaps and Systemic Challenges in Antidepressant Prescribing: Insights from Jordanian Psychiatry Practice. [PDF]

Healthcare (Basel)
Abdulhaq B, Sarhan W, Saadeh M, Alkayid S, Libzo DT, Sadaqa M, Dardas LA.   +6 more
europepmc   +3 more sources

Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?

Frontiers in Pharmacology, 2022
Dopamine and its receptors are currently recognized targets for the treatment of several neuropsychiatric disorders, including Parkinson’s disease, schizophrenia, some drug use addictions, as well as depression.
Fangyi Zhao, Fangyi Zhao, Ziqian Cheng, Ziqian Cheng, Jingjing Piao, Jingjing Piao, Ranji Cui, Ranji Cui, Bingjin Li, Bingjin Li   +9 more
doaj   +1 more source

The Genetic Underpinnings of Affective Temperaments: Identifying Novel Risk Variants with a Whole Genome Analytical Approach

European Psychiatry, 2022
One reason behind the failure to understand the neurobiological background of affective disorders and develop more effective treatments is their heterogeneity warranting identification of clinically meaningful endophenotypes.
X. Gonda, N. Eszlari, D. Torok, Z. Gal, A. Millinghoffer, P. Antal, G. Juhasz, G. Bagdy   +7 more
doaj   +1 more source

Association of genetic variants of Glutamate Metabotropic Receptor 5 gene and state-anhedonia

European Psychiatry, 2022
Introduction Andedonia is one of the core symptoms of depression. It is known that in case of depressed individuals experiencing anhedonia, the classical antidepressants are often ineffective, thus investigation of this symptom would be essential ...
D. Török, X. Gonda, Z. Gal, N. Eszlari, G. Bagdy, G. Juhasz, P. Petschner   +6 more
doaj   +1 more source

Genetic underpinnings of affective temperaments: a pilot GWAS investigation identifies a new genome-wide significant SNP for anxious temperament in ADGRB3 gene

Translational Psychiatry, 2021
Although recently a large-sample GWASs identified significant loci in the background of depression, the heterogeneity of the depressive phenotype and the lack of accurate phenotyping hinders applicability of findings.
Xenia Gonda, Nora Eszlari, Dora Torok, Zsofia Gal, Janos Bokor, Andras Millinghoffer, Daniel Baksa, Peter Petschner, Peter Antal, Gerome Breen, Gabriella Juhasz, Gyorgy Bagdy   +11 more
doaj   +1 more source

Epigenetic Mechanism of Early Life Stress-Induced Depression: Focus on the Neurotransmitter Systems

Frontiers in Cell and Developmental Biology, 2022
Depression has an alarmingly high prevalence worldwide. A growing body of evidence indicates that environmental factors significantly affect the neural development and function of the central nervous system and then induce psychiatric disorders.
Ziqian Cheng, Ziqian Cheng, Jingyun Su, Jingyun Su, Kai Zhang, Huiyi Jiang, Bingjin Li, Bingjin Li   +7 more
doaj   +1 more source

Effectiveness of vortioxetine in patients with major depressive disorder and comorbid Alzheimer’s disease in routine clinical practice: An analysis of a post-marketing surveillance study in South Korea

Frontiers in Aging Neuroscience, 2023
BackgroundVortioxetine has demonstrated procognitive effects in patients with major depressive disorder (MDD). We assessed the effectiveness and safety of vortioxetine in a cohort of patients with MDD and comorbid Alzheimer’s disease participating in a ...
Eduardo Cumbo, Michael Adair, Daniel Oudin Åstrom, Michael Cronquist Christensen   +3 more
doaj   +1 more source

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]

, 2013
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
A McQuillin, A Scimemi, AA Boucher, AD Michel, AJ Law, AM Basso, AN Guerra, AV Gourine, B Sperlagh, B Sperlagh, B Sperlagh, Beáta Sperlágh, BP Guiard, C Csolle, C Delarasse, C Lavebratt, C Toro, C Verderio, Cecilia Csölle, CG Thomas, CM Anderson, DS Hasin, DT Balu, E Castren, E Fuchs, E Mundo, E Shimizu, E. Sylvester Vizi, Edit Papp, EJ Nestler, EK Green, F Frenois, F Karege, Flóra Gölöncsér, G Nagy, G Nowak, G Sanacora, G Sanacora, G Sanacora, Gabriella Zsilla, GE Hardingham, GE Wood, JE Malberg, JF Cryan, JF Cryan, JH Meador-Woodruff, JL Warner-Schmidt, JM Boyce-Rustay, JM Krueger, JO Groves, JS Barnholtz, K Hashimoto, K Hejjas, K Martinowich, K Viwatpinyo, K Wager-Smith, KR Tovar, L Backlund, L Bocchio-Chiavetto, L Papp, L Papp, L Patti, L Santarelli, L Stokes, L Zhang, LM Monteggia, M Baranyi, M Barbera-Cremades, M Diaz-Hernandez, M Grigoroiu-Serbanescu, M Koehl, M Masin, M Solle, ME Kozisek, ME Kozisek, ME Szapacs, ML Barbaccia, MT Miras-Portugal, MW Pfaffl, Mária Baranyi, N Barden, N Drigues, O Berton, OH Lowry, P Fossati, P Skolnick, P Soronen, P Vanhoutte, PA Lapchak, Peter Illes, R Dantzer, RC Hogg, RJ Griffiths, RJ Rodrigues, RS Duman, S Alloisio, S Duan, S Lucae, S Monleon, S Schnydrig, SN Williams, SP Banerjee, T Balazsa, T Deltheil, T Deltheil, T Zigova, Thierry Amédée, V Shukla, VF Labrousse, VM Brautigam, W Peng, Y Dwivedi, Y Shirayama, Z Hracskó, Ágnes Kittel   +114 more
core   +7 more sources

The Effect of the 5-HT4 Agonist, Prucalopride, on a Functional Magnetic Resonance Imaging Faces Task in the Healthy Human Brain

Frontiers in Psychiatry, 2022
Depression is a common and often recurrent illness with significant negative impact on a global scale. Current antidepressants are ineffective for up to one third of people with depression, many of whom experience persistent symptomatology.
Angharad N. de Cates, Angharad N. de Cates, Marieke A. G. Martens, Marieke A. G. Martens, Lucy C. Wright, Lucy C. Wright, Cassandra D. Gould van Praag, Cassandra D. Gould van Praag, Liliana P. Capitão, Liliana P. Capitão, Daisy Gibson, Daisy Gibson, Philip J. Cowen, Philip J. Cowen, Catherine J. Harmer, Catherine J. Harmer, Catherine J. Harmer, Susannah E. Murphy, Susannah E. Murphy   +18 more
doaj   +1 more source

Experimental pharmacological research regarding the antidepressant effect of associating doxepin and selegiline in normal mice [PDF]

, 2019
The severity and complexity of depression can vary widely among individuals, thus making single drug therapy ineffective in some cases. Taking this fact into account and using a mouse model, we set on investigating the possibility of obtaining a ...
Chiriță, Cornel, Dănciulescu Miulescu, Rucsandra E, Limban, Carmen, Marineci, Cristina D, Mireșan, Horațiu, Negreș, Simona, Nuță, Diana C, Zbârcea, Cristina E, Ștefănescu, Emil   +8 more
core   +2 more sources