Results 11 to 20 of about 253,402 (288)

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
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Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
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Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice [PDF]

, 2015
Poor micturition control may cause profound distress, because proper voiding is mandatory for an active social life. Micturition results from the subtle interplay of central and peripheral components.
Antonio, Caretta, Claus, Mirko, Mar\ueda Jimena, Ricatti, Maurizio, Ballabio, Mucignat, Carla, Redaelli, Marco, Simonetto, Marialaura   +6 more
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AM-251, A Cannabinoid Antagonist, Modifies the Dynamics of Sleep–Wake Cycles in Rats

Frontiers in Pharmacology, 2019
Study Objectives: (a) To describe the microarchitecture of wakefulness and sleep following administrations of 5- and 10-mg/kg AM-251 in rats. (b) To develop a new statistical method to follow bout-to-bout dynamics.Method: Wistar rats (n = 6) had been ...
Emese Bogáthy, Noémi Papp, Szilvia Vas, Szilvia Vas, Szilvia Vas, György Bagdy, György Bagdy, György Bagdy, György Bagdy, László Tóthfalusi   +9 more
doaj   +1 more source

Ketamine: NMDA receptors and beyond [PDF]

, 2016
Human studies examining the effects of the dissociative anesthetic ketamine as a model for psychosis and as a rapidly acting antidepressant have spurred great interest in understanding ketamine's actions at molecular, cellular, and network levels ...
Izumi, Yukitoshi, Mennerick, Steven, Zorumski, Charles F   +2 more
core   +2 more sources

Neural Predictors of the Antidepressant Placebo Response

Pharmaceuticals, 2019
The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates.
Danielle Rette, Erin McDonald, Dan V. Iosifescu, Katherine A. Collins   +3 more
doaj   +1 more source

Neural correlates of outcome of the psychotherapy compared to antidepressant therapy in anxiety and depression disorders: a meta-analysis [PDF]

, 2017
The most prevalent mental disorders, anxiety and depression, are commonly associated with structural and functional changes in the fronto-limbic brain areas.
Aceto, Paola, Altavilla, Daniela, Di Giorgio, Chiara, Kalsi, Navkiran, Lai, Carlo, Tambelli, Renata, Trentini, Cristina   +6 more
core   +3 more sources

Incidence and drug treatment of emotional distress after cancer diagnosis : a matched primary care case-control study [PDF]

, 2012
Notes This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.Peer ...
A J Lee, C Bond, C Burton, C Burton, DR Cox, E Martin-Merino, F Desplenter, F Hansen, G Laekeman, G Rait, J Madden, JC Holland, JL Roffman, K Lefevre, KC Yung, L Hodges, M Miovic, M Sharpe, M Vahdaninia, M Watson, MB First, MJ Massie, NF Khan, P Lockhart, P Murchie, PP Roy-Byrne, R Morris, R Munoz-Arroyo, RA Lewis, S Simoens, S Wein, SB Patten, TL Deshields, V Strong   +33 more
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Association between insight and internalized stigma and other clinical factors among patients with depression: A cross-sectional study

Indian Journal of Psychiatry, 2020
Background: Insight influences treatment adherence among patients with depression. These patients also experience considerable social and self-stigma. The relationship between insight and internalized stigma has been extensively studied among patients ...
Luke Sy-Cherng Woon, Siew Im Khoo, Azlin Baharudin, Marhani Midin   +3 more
doaj   +1 more source

Biochemical and immunocytochemical studies of the testicular alteration caused by Amitriptyline in adult male rat [PDF]

Journal of Bioscience and Applied Research, 2018
Amitriptyline is one of the first reference tricyclic antidepressants (TCAs) with sedative and analgesic properties. This study aimed to investigate the testicular indices that influenced by amitriptyline treatment and examined it by biochemical ...
Ehab Tousson, Somia Zaki, Ezar Hafez, Amani Gad   +3 more
doaj   +1 more source