Neural correlates of outcome of the psychotherapy compared to antidepressant therapy in anxiety and depression disorders: a meta-analysis [PDF]
, 2017 The most prevalent mental disorders, anxiety and depression, are commonly associated with structural and functional changes in the fronto-limbic brain areas.
Aceto, Paola +6 more
core +3 more sources
Total and Partial Sleep Deprivation in Clomipramine-Treated Endogenous Depressives [PDF]
, 1990 Improvement in depression after total sleep deprivation (TSD) is, as a rule, followed by relapse after subsequent ad libitum sleep. This study is addressed to the question of how nocturnal partial sleep following TSD affects this relapse.
Beersma, Domien, +2 more
core +11 more sources
AM-251, A Cannabinoid Antagonist, Modifies the Dynamics of Sleep–Wake Cycles in Rats
Frontiers in Pharmacology, 2019 Study Objectives: (a) To describe the microarchitecture of wakefulness and sleep following administrations of 5- and 10-mg/kg AM-251 in rats. (b) To develop a new statistical method to follow bout-to-bout dynamics.Method: Wistar rats (n = 6) had been ...
Emese Bogáthy +9 more
doaj +1 more source
Preclinical discovery of duloxetine for the treatment of depression [PDF]
, 2012 Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María +4 more
core +2 more sources
Neural Predictors of the Antidepressant Placebo Response
Pharmaceuticals, 2019 The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates.
Danielle Rette +3 more
doaj +1 more source
Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]
, 2006 Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y +79 more
core +1 more source
Antidepressant use and glycemic control in diabetic population: A meta-analysis
Indian Journal of Endocrinology and Metabolism, 2020 Background: Depression is prevalent in the diabetic population. Primary care physician is busy in treating diabetes and depression among them goes unnoticed.
Meenakshi Khapre +3 more
doaj +1 more source
Serotonin antidepressants and atrial fibrillation burden from cardiac implantable electronic devices
Journal of Arrhythmia, 2023 Objective Depression and anxiety show a bidirectional relationship with atrial fibrillation (AF). Antidepressant use is associated with a reduction in the incidence of AF.
Youlin Koh +4 more
doaj +1 more source
Design, synthesis, molecular modelling and in vitro screening of monoamine oxidase inhibitory activities of novel quinazolyl hydrazine derivatives [PDF]
Royal Society Open Science, 2020 A new series of N'-substituted benzylidene-2-(4-oxo-2-phenyl-1,4-dihydroquinazolin-3(2H)-yl)acetohydrazide (5a–5h) has been synthesized, characterized by FT-IR, NMR spectroscopy and mass spectrometry and tested against human monoamine oxidase (MAO) A and
Adel Amer +6 more
doaj +1 more source
Experimental Pharmacological Research Regarding the Potential Antidepressant Activity Induced by Some Newly Synthesised Dibenzo[a,d]cycloheptene Compounds [PDF]
, 2015 Background. Depression is a relatively frequent encountered mental disorder in the general population, affecting both the quality of the individual life and its ability to perform the social tasks; it is generally accepted that new studies related to ...
Junghină, Adrian +3 more
core +4 more sources