Results 11 to 20 of about 276,787 (297)

Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus

Journal of Neuroscience, 2000
Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may contribute to the pathophysiology of depression. The aim of this study was to investigate the effect of antidepressants on hippocampal neurogenesis in the adult rat ...
J. Malberg, A. Eisch, E. Nestler, R. Duman   +3 more
semanticscholar   +1 more source

3D-ALMOND-QSAR Models to Predict the Antidepressant Effect of Some Natural Compounds

Pharmaceutics, 2021
The current treatment of depression involves antidepressant synthetic drugs that have a variety of side effects. In searching for alternatives, natural compounds could represent a solution, as many studies reported that such compounds modulate the ...
Speranta Avram, Miruna Silvia Stan, Ana Maria Udrea, Cătălin Buiu, Anca Andreea Boboc, Maria Mernea   +5 more
doaj   +1 more source

Design, Synthesis, and In Vivo and In Silico Evaluation of Coumarin Derivatives with Potential Antidepressant Effects

Molecules, 2021
In this study, a series of coumarin derivatives were designed and synthesized, their structures were characterized using nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS) testing methods. In the pharmacological experiment, two
Xuekun Wang, Hao Zhou, Xinyu Wang, Kang Lei, Shiben Wang   +4 more
doaj   +1 more source

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Nature, 2016
Major depressive disorder affects around 16 per cent of the world population at some point in their lives. Despite the availability of numerous monoaminergic-based antidepressants, most patients require several weeks, if not months, to respond to these ...
P. Zanos, R. Moaddel, Patrick J. Morris, Polymnia Georgiou, J. Fischell, G. Elmer, M. Alkondon, P. Yuan, H. Pribut, Nagendra S. Singh, K. Dossou, Yuhong Fang, Xi-Ping Huang, Cheryl L. Mayo, I. Wainer, E. Albuquerque, S. Thompson, Craig J. Thomas, C. Zarate, T. Gould   +19 more
semanticscholar   +1 more source

AM-251, A Cannabinoid Antagonist, Modifies the Dynamics of Sleep–Wake Cycles in Rats

Frontiers in Pharmacology, 2019
Study Objectives: (a) To describe the microarchitecture of wakefulness and sleep following administrations of 5- and 10-mg/kg AM-251 in rats. (b) To develop a new statistical method to follow bout-to-bout dynamics.Method: Wistar rats (n = 6) had been ...
Emese Bogáthy, Noémi Papp, Szilvia Vas, Szilvia Vas, Szilvia Vas, György Bagdy, György Bagdy, György Bagdy, György Bagdy, László Tóthfalusi   +9 more
doaj   +1 more source

Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study.

American Journal of Psychiatry, 2019
OBJECTIVE About one-third of patients with depression fail to achieve remission despite treatment with multiple antidepressants. This study compared the efficacy and safety of switching patients with treatment-resistant depression from an ineffective ...
V. Popova, E. Daly, M. Trivedi, K. Cooper, R. Lane, P. Lim, Christine Mazzucco, D. Hough, M. Thase, R. Shelton, P. Molero, E. Vieta, M. Bajbouj, H. Manji, W. Drevets, Jaskaran Singh   +15 more
semanticscholar   +1 more source

Neural Predictors of the Antidepressant Placebo Response

Pharmaceuticals, 2019
The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates.
Danielle Rette, Erin McDonald, Dan V. Iosifescu, Katherine A. Collins   +3 more
doaj   +1 more source

Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation

Science, 2019
Why is ketamine an antidepressant? A better understanding of the mechanisms underlying the action of antidepressants is urgently needed. Moda-Sava et al.
R. N. Moda-Sava, Mitchell H. Murdock, P. Parekh, R. Fetcho, Ben S. Huang, T. N. Huynh, Jonathan Witztum, D. Shaver, D. Rosenthal, E. Alway, Katherine Lopez, Y. Meng, L. Nellissen, L. Grosenick, L. Grosenick, T. Milner, K. Deisseroth, H. Bito, H. Kasai, C. Liston   +19 more
semanticscholar   +1 more source

Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial.

JAMA psychiatry, 2019
Importance Controlled studies have shown short-term efficacy of esketamine for treatment-resistant depression (TRD), but long-term effects remain to be established.
E. Daly, M. Trivedi, A. Janik, Honglan Li, Yun Zhang, Xiang Li, R. Lane, P. Lim, A. Duca, D. Hough, M. Thase, J. Zajecka, A. Winokur, I. Divacka, A. Fagiolini, W. Cubała, I. Bitter, P. Blier, R. Shelton, P. Molero, H. Manji, W. Drevets, Jaskaran Singh   +22 more
semanticscholar   +1 more source

Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

Psychological Medicine, 2018
Background Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression.
Fernanda Palhano-Fontes, Dayanna Barreto, H. Onias, K. Andrade, Morgana M. Novaes, J. Pessoa, S. Mota-Rolim, F. Osório, R. Sanches, R. G. dos Santos, L. F. Tófoli, Gabriela de Oliveira Silveira, M. Yonamine, J. Riba, F. Santos, Antonio A Silva-Junior, J. Alchieri, N. Galvão-Coelho, B. Lobão-Soares, J. Hallak, Emerson Arcoverde, J. P. Maia-de-Oliveira, D. Araujo   +22 more
semanticscholar   +1 more source