Results 41 to 50 of about 285,368 (185)

Soluble Epoxide Hydrolase Inhibitor: A Novel Potential Therapeutic or Prophylactic Drug for Psychiatric Disorders

Frontiers in Pharmacology, 2019
Psychiatric disorders, including depression and schizophrenia, affect millions of individuals worldwide. However, the precise neurobiology of psychiatric disorders remains unclear. Accumulating evidence suggests that various inflammatory processes play a
Qian Ren, Qian Ren
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FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy

Microbiology Spectrum, 2022
Antibiotic resistance poses a significant hurdle in combating global public health crises, prompting the development of novel therapeutics. Strategies to enhance the intracellular killing of mycobacteria by targeting host defense mechanisms offer ...
Jia Wang, Jian Sha, Emily Strong, Ashok K. Chopra, Sunhee Lee   +4 more
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Intermittent fasting produces antidepressant-like effects by modulating dopamine D1 receptors in the medial prefrontal cortex

Neurobiology of Disease
Nutritional psychiatry has gained increasing attention, particularly in exploring dietary interventions for depression treatment. As a potential non-drug intervention, intermittent fasting (IF) has gradually attracted the interest of researchers, but its
Jingjing Piao, Hongyu Chen, Xinmiao Piao, Ziqian Cheng, Fangyi Zhao, Ranji Cui, Bingjin Li   +6 more
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Functional connectivity of brain structures correlates with treatment outcome in Major Depressive Disorder

Frontiers in Psychiatry, 2011
Identifying biosignatures to assess the probability of response to an antidepressant for patients with Major Depressive Disorder (MDD) is critically needed. Functional connectivity MRI (fcMRI) offers the promise to provide such a measure.
F. Andrew eKozel, Uma eRao, Hanzhang eLu, Paul A. Nakonezny, Paul A. Nakonezny, Bruce eGrannemann, Tamara eMcGregor, Paul E. Croarkin, Kimberly S. Mapes, Carol A Tamminga, Madhukar H. Trivedi   +10 more
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Incidence and drug treatment of emotional distress after cancer diagnosis : a matched primary care case-control study [PDF]

, 2012
Notes This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.Peer ...
A J Lee, C Bond, C Burton, C Burton, DR Cox, E Martin-Merino, F Desplenter, F Hansen, G Laekeman, G Rait, J Madden, JC Holland, JL Roffman, K Lefevre, KC Yung, L Hodges, M Miovic, M Sharpe, M Vahdaninia, M Watson, MB First, MJ Massie, NF Khan, P Lockhart, P Murchie, PP Roy-Byrne, R Morris, R Munoz-Arroyo, RA Lewis, S Simoens, S Wein, SB Patten, TL Deshields, V Strong   +33 more
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Subcutaneous Ketamine in Depression: A Systematic Review

Frontiers in Psychiatry, 2021
Background: Ketamine has been shown to produce a rapid and robust antidepressant effect. Though numerous routes of administration have been studied, subcutaneous (SC) has proven to be a convenient and cost-effective route making its use particularly ...
Vitor Breseghello Cavenaghi, Leandro Paulino da Costa, Acioly Luiz Tavares Lacerda, Edson Shiguemi Hirata, Eurípedes Constantino Miguel, Renério Fraguas, Renério Fraguas   +6 more
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Experimental pharmacological research regarding the antidepressant effect of associating doxepin and selegiline in normal mice [PDF]

, 2019
The severity and complexity of depression can vary widely among individuals, thus making single drug therapy ineffective in some cases. Taking this fact into account and using a mouse model, we set on investigating the possibility of obtaining a ...
Chiriță, Cornel, Dănciulescu Miulescu, Rucsandra E, Limban, Carmen, Marineci, Cristina D, Mireșan, Horațiu, Negreș, Simona, Nuță, Diana C, Zbârcea, Cristina E, Ștefănescu, Emil   +8 more
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Comparative characteristics of proton pump inhibitor effectiveness in the treatment of gastric ulcer and duodenal ulcer

Current Issues in Pharmacy and Medical Sciences, 2020
Aim. The aim of this study is to evaluate the efficiency of proton pump inhibitors in the treatment of gastric and duodenal ulcers as based on literature.
Balitska Olesya P., Germanyuk Tamara A., Hryhoruk Yuliia M., Ivko Tatiana I., Tomashevska Yuliia O., Koval Vasyl M., Polishchuk Yuliia M., Hutsol Viktoriia V., Artemchuk Myhailo A.   +8 more
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Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications. [PDF]

, 2017
Current therapeutic approaches to depression fail for millions of patients due to lag in clinical response and non-adherence. Here we provide new support for the antidepressant effect of an anesthetic drug, ketamine, by Inverse-Frequency Analysis of ...
Abagyan, Ruben, Atayee, Rabia, Cohen, Isaac V, Makunts, Tigran   +3 more
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Pharmacological Characterization of Toludesvenlafaxine as a Triple Reuptake Inhibitor

Frontiers in Pharmacology, 2021
Toludesvenlafaxine hydrochloride dihydrate is a novel chemical entity and a potential triple monoamine reuptake inhibitor. This study characterized the in vitro triple reuptake inhibition activity, antidepressant-like activity in animals, and ...
Haibo Zhu, Wenyan Wang, Chunjie Sha, Wei Guo, Chunmei Li, Fengjuan Zhao, Hongbo Wang, Wanglin Jiang, Jingwei Tian, Jingwei Tian   +9 more
doaj   +1 more source