Results 41 to 50 of about 276,787 (297)
Molecules, 2022 Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for treatment of depression and other neurological disorders. Evidence has suggested that patients with atypical depression preferentially respond to natural product MAOIs ...
Narayan D. Chaurasiya +3 more
doaj +1 more source
An electroencephalographic signature predicts antidepressant response in major depression
Nature Biotechnology, 2019 Antidepressants are widely prescribed, but their efficacy relative to placebo is modest, in part because the clinical diagnosis of major depression encompasses biologically heterogeneous conditions. Here, we sought to identify a neurobiological signature
Wei Wu +26 more
semanticscholar +1 more source
The role of dissociation in ketamine’s antidepressant effects
Nature Communications, 2020 Ketamine produces immediate antidepressant effects and has inspired research into next-generation treatments. Ketamine also has short term dissociative effects, in which individuals report altered consciousness and perceptions of themselves and their ...
E. Ballard, C. Zarate
semanticscholar +1 more source
Arthritis Care &Research, EarlyView.Objective This study investigates the association between discordance in commonly collected clinical indicators of rheumatoid arthritis (RA) disease activity and abnormalities in quantitative sensory testing (QST) observed in individuals with nociplastic pain.
Clarice P. Lin +10 more
wiley +1 more source
Animals, 2020 Animal welfare assessment requires measures for positive affective state. Pharmacological agents that manipulate affective state can be used to evaluate novel biomarkers for affective state assessment.
Laura E. Marsh +4 more
doaj +1 more source
Biomolecules, 2022 The therapy of depression is challenging and still unsatisfactory despite the presence of many antidepressant drugs on the market. Consequently, there is a continuous need to search for new, safer, and more effective antidepressant therapeutics. Previous
Karthikkumar Venkatachalam +5 more
doaj +1 more source
Beyond Inflammation: Why Understanding the Brain Matters in Inflammatory Arthritis
Arthritis Care &Research, EarlyView.Persistent pain remains a major challenge in inflammatory arthritis, even when joint inflammation is well controlled. Pain and associated symptoms such as fatigue cannot be explained by peripheral inflammation alone but reflect altered central pain processing. These changes may arise through “top‐down” mechanisms, reflecting pre‐existing dysfunction in
Eoin M. Kelleher +2 more
wiley +1 more source
Frontiers in PsychiatryObjectiveAbnormal cognitive functioning is a core symptom of Major Depressive Disorder (MDD) and is strongly correlated with MDD prognosis. Current studies suggest that the occurrence of MDD may be related to oxidative stress-induced inflammation ...
Yan Qing Xi +22 more
doaj +1 more source
Pharmaceuticals, 2023 Two polyphenols–hyperoside (HYP) and protocatechuic acid (PCA) were reported to exert antidepressant activity in rodents after acute treatment. Our previous study also showed that this activity might have been influenced by the monoaminergic system and ...
Jolanta Orzelska-Górka +7 more
doaj +1 more source
GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions.
Journal of Clinical Investigation, 2019 A single sub-anesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients, addressing a major unmet need for the treatment of mood disorders.
Danielle M. Gerhard +11 more
semanticscholar +1 more source