Results 41 to 50 of about 267,421 (217)
Subcutaneous Ketamine in Depression: A Systematic Review
Frontiers in Psychiatry, 2021 Background: Ketamine has been shown to produce a rapid and robust antidepressant effect. Though numerous routes of administration have been studied, subcutaneous (SC) has proven to be a convenient and cost-effective route making its use particularly ...
Vitor Breseghello Cavenaghi +6 more
doaj +1 more source
Nonparametric Bayesian Approach to Treatment Ranking in Network Meta-Analysis with Application to Comparisons of Antidepressants [PDF]
arXiv, 2022 Network meta-analysis is a powerful tool to synthesize evidence from independent studies and compare multiple treatments simultaneously. A critical task of performing a network meta-analysis is to offer ranks of all available treatment options for a specific disease outcome. Frequently, the estimated treatment rankings are accompanied by a large amount
arxiv
NMDA Receptor Blockade at Rest Triggers Rapid Behavioural Antidepressant Responses
Nature, 2011 Clinical studies consistently demonstrate that a single sub-psychomimetic dose of ketamine, an ionotropic glutamatergic NMDAR (N-methyl-D-aspartate receptor) antagonist, produces fast-acting antidepressant responses in patients suffering from major ...
Anita E. Autry +7 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2019 Psychiatric disorders, including depression and schizophrenia, affect millions of individuals worldwide. However, the precise neurobiology of psychiatric disorders remains unclear. Accumulating evidence suggests that various inflammatory processes play a
Qian Ren, Qian Ren
doaj +1 more source
Frontiers in Behavioral Neuroscience, 2021 The serendipitous discovery of ketamine’s antidepressant effects represents one of the major landmarks in neuropsychopharmacological research of the last 50 years.
Michael Colla +4 more
doaj +1 more source
Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin
Neuropsychopharmacology, 2020 Twenty-four hours after administration, ketamine exerts rapid and robust antidepressant effects that are thought to be mediated by activation of the mechanistic target of rapamycin complex 1 (mTORC1).
C. Abdallah +13 more
semanticscholar +1 more source
The pharmacological management of depression – Update 2017
South African Family Practice, 2017 Depression affects nearly 350 million people worldwide. Local data indicates that approximately 17% of all South Africans will experience at least one episode of depression in their lifetime.
Elzbieta Osuch, Andre Marais
doaj +1 more source
Antidepressant-like Effects of Neuropeptide SF (NPSF) [PDF]
World Journal of Research and Review (WJRR) ISSN:2455-3956,
Volume-4, Issue-5, May 2017 Pages 26-30, 2020 Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and ...
arxiv
Treatments for pregestational chronic conditions during pregnancy: emulating a target trial with a treatment decision design [PDF]
arXiv, 2023 As a solution to methodologic challenges inherent to estimating causal effects of exposures in early pregnancy, we suggest emulating a target trial using a treatment decision design, wherein time zero is centered around clinical landmarks where treatment decisions may occur, such as the date of preconception counseling or prenatal care initiation ...
arxiv
Psychiatry and Clinical Neurosciences, 2019 Major depressive disorder (MDD) is one of the most disabling psychiatric disorders. Approximately one‐third of the patients with MDD are treatment resistant to the current antidepressants.
K. Hashimoto
semanticscholar +1 more source