Results 41 to 50 of about 295,419 (335)

Ketamine: NMDA receptors and beyond [PDF]

, 2016
Human studies examining the effects of the dissociative anesthetic ketamine as a model for psychosis and as a rapidly acting antidepressant have spurred great interest in understanding ketamine's actions at molecular, cellular, and network levels ...
Izumi, Yukitoshi, Mennerick, Steven, Zorumski, Charles F   +2 more
core   +2 more sources

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Total and Partial Sleep Deprivation in Clomipramine-Treated Endogenous Depressives [PDF]

, 1990
Improvement in depression after total sleep deprivation (TSD) is, as a rule, followed by relapse after subsequent ad libitum sleep. This study is addressed to the question of how nocturnal partial sleep following TSD affects this relapse.
Beersma, Domien,, Elsenga, Simon,, Hoofdakker, Rutger H. van den,   +2 more
core   +11 more sources

Functional connectivity of brain structures correlates with treatment outcome in Major Depressive Disorder

Frontiers in Psychiatry, 2011
Identifying biosignatures to assess the probability of response to an antidepressant for patients with Major Depressive Disorder (MDD) is critically needed. Functional connectivity MRI (fcMRI) offers the promise to provide such a measure.
F. Andrew eKozel, Uma eRao, Hanzhang eLu, Paul A. Nakonezny, Paul A. Nakonezny, Bruce eGrannemann, Tamara eMcGregor, Paul E. Croarkin, Kimberly S. Mapes, Carol A Tamminga, Madhukar H. Trivedi   +10 more
doaj   +1 more source

Natural Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma

Molecules, 2022
Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for treatment of depression and other neurological disorders. Evidence has suggested that patients with atypical depression preferentially respond to natural product MAOIs ...
Narayan D. Chaurasiya, Francisco Leon, Ilias Muhammad, Babu L. Tekwani   +3 more
doaj   +1 more source

Experimental pharmacological research regarding some new quinazolin-4-ones derivatives [PDF]

, 2019
A series of new compounds with quinazolin-4-one structure, synthesized by the Pharmaceutical Chemistry Department of the Faculty of Pharmacy of the University of Medicine and Pharmacy “Carol Davila” Bucharest, was studied.
Bratu, Mihaela, Chiriță, Cornel, Chiriță, Ileana C, Limban, Carmen, Marineci, Cristina D, Negreș, Simona, Nuță, Diana C, Zbârcea, Cristina E, Ștefănescu, Emil   +8 more
core   +1 more source

D-cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: a systematic review and meta-analysis of individual participant data [PDF]

, 2017
Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear.
Altemus, Margaret, Anderson, Page, Andersson, Erik, Cukor, Judith, Davis, Michael, DCS Anxiety Consortium, de Kleine, Rianne A., Difede, JoAnn, Dunlop, Boadie W., Farrell, Lara J., Fernández de la Cruz, Lorena, Finck, Claudia, Frumento, Paolo, Geffken, Gary R., Geller, Daniel, Gerardi, Maryrose, Golfels, Fabian, Goodman, Wayne K., Guastella, Adam J., Gutner, Cassidy, Hendriks, Gert-Jan, Heyman, Isobel, Hofmann, Stefan G., Jovanovic, Tanja, Kushner, Matt G., Lee, Francis S., Lenze, Eric J., Levinson, Cheri A., Lewin, Adam B., Mataix-Cols, David, McConnell, Harry, McNamara, Joseph P., Monzani, Benedetta, Murphy, Tanya K., Norrholm, Seth, Otto, Michael W., Plag, Jens, Pollack, Mark H., Pérez-Vigil, Ana, Ressler, Kerry J., Rodebaugh, Thomas L., Rosenfield, David, Rothbaum, Barbara O., Rück, Christian, Scheeringa, Michael S., Siewert-Siegmund, Anja, Smits, Jasper A.J., Storch, Eric A., Ströhle, Andreas, Tart, Candyce D., Thuras, Paul, Tolin, David F., van Minnen, Agnes, Waters, Allison M., Weems, Carl F., Wilhelm, Sabine, Wyka, Katarzyna   +56 more
core   +1 more source

Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund, Johan Reutfors, Thomas Frisell, Fredrik Piehl   +3 more
wiley   +1 more source

Pronounced Inter-Individual Variation in Plasma Cortisol Response to Fluoxetine Hydrochloride in the Pig

Animals, 2020
Animal welfare assessment requires measures for positive affective state. Pharmacological agents that manipulate affective state can be used to evaluate novel biomarkers for affective state assessment.
Laura E. Marsh, Robyn Terry, Alexandra L. Whittaker, Stefan Hiendleder, Cameron R. Ralph   +4 more
doaj   +1 more source

The Novel Pimavanserin Derivative ST-2300 with Histamine H₃ Receptor Affinity Shows Reduced 5-HT_2A Binding, but Maintains Antidepressant- and Anxiolytic-like Properties in Mice

Biomolecules, 2022
The therapy of depression is challenging and still unsatisfactory despite the presence of many antidepressant drugs on the market. Consequently, there is a continuous need to search for new, safer, and more effective antidepressant therapeutics. Previous
Karthikkumar Venkatachalam, Sicheng Zhong, Mariam Dubiel, Grzegorz Satała, Bassem Sadek, Holger Stark   +5 more
doaj   +1 more source