Results 61 to 70 of about 298,427 (334)

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Medicaid spending burden among beneficiaries with treatment-resistant depression. [PDF]

, 2019
AIM: To evaluate Medicaid spending and healthcare resource utilization (HRU) in treatment-resistant depression (TRD). MATERIALS & METHODS: TRD beneficiaries were identified from Medicaid claims databases (January 2010-March 2017) and matched 1:1 with ...
Greenberg, Paul E., Jacques, Philippe, Lefebvre, Patrick, Lejeune, Dominique, Pilon, Dominic, Sheehan, John J., Singer, David, Szukis, Holly   +7 more
core   +1 more source

The reported use and effectiveness of Hypericum (St John’s wort) on affective symptoms in a depression self-help group [PDF]

, 2002
A recent meta-analysis suggested that Hypericum perforatum (St John’s wort) is an effective treatment for mild to moderate depression and may have a superior side-effect profile to some antidepressant drugs.
Baldwin, D.S., Dyson, R., Jenkins, G., Mayers, A.G., Tiernan, A.   +4 more
core   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Enhancing antidepressant safety surveillance: comparative analysis of adverse drug reaction signals in spontaneous reporting and healthcare claims databases

Frontiers in Pharmacology
Background/Objective: Spontaneous reporting systems (SRS) such as the Korea Adverse Event Reporting System (KAERS) are limited in their ability to detect adverse drug reaction (ADR) signals due to their limited data on drug use.
Taehyung Kim, Taehyung Kim, Xinying Jiang, Youran Noh, Youran Noh, Maryanne Kim, Maryanne Kim, Song Hee Hong, Song Hee Hong   +8 more
doaj   +1 more source

Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder. [PDF]

, 2019
Changes in gene expression (GE) during antidepressant treatment may increase understanding of the action of antidepressant medications and serve as biomarkers of efficacy.
Congdon, Eliza, Cook, Ian A, Coppola, Giovanni, Hamilton, Steven P, Hunter, Aimee M, Krantz, David E, Leuchter, Andrew F   +6 more
core   +1 more source

The role of phospholipid as a solubility- and permeability-enhancing excipient for the improved delivery of the bioactive phytoconstituents of Bacopa monnieri [PDF]

, 2016
In an attempt to improve the solubility and permeability of Standardized Bacopa Extract (SBE), a complexation approach based on phospholipid was employed.
Bobde, Yamini S, Dave, Vivek S., Dhore, Pradip W., Gupta, Deepak, Mack, Connor, Raut, Nishikant, Saoji, Suprit   +6 more
core   +2 more sources

Signaling pathways linking behavior to neurogenesis in healthy brain and disease [PDF]

, 2020
Self-repair of the adult brain is limited – most diseases lack effective therapy. In order to better understand how a regenerative response can be achieved, studying mechanisms shaping the neurogenic niche, from environmental factors to intrinsic ...
Klempin, Friederike
core   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Predictive, Data‐Driven Design of Red‐Light Photoredox Catalysts for C─Heteroatom Bond Formation

Angewandte Chemie, EarlyView.
From redox numbers to red light: Donor oxidation and core reduction potentials predict E0‐0 in cyanoarene dyes, guiding selection of an efficient red‐light catalyst, 4MeODPATPN (PC13). Under 620 nm light, PC13 facilitates Ni‐catalyzed C─heteroatom cross‐couplings (C─N, C─O, C─S) with high functional‐group tolerance and reduced hydrodehalogenation ...
Amir Gizatullin, Tingting Yuan, Sascha Grotjahn, Luigi Cavallo, Burkhard König, Chen Zhu, Magnus Rueping   +6 more
wiley   +2 more sources