Telomere length as a predictor of response to Pioglitazone in patients with unremitted depression: a preliminary study. [PDF]
, 2016 We studied peripheral leukocyte telomere length (LTL) as a predictor of antidepressant response to PPAR-γ agonist in patients with unremitted depression.
Blackburn, E +4 more
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Pharmacological mechanism of natural antidepressants: the role of epigenetic modifications
Frontiers in PharmacologyMDD is a complex mental illness shaped by the interplay between genetic vulnerability and environmental triggers. Its underlying pathophysiological processes are now understood to be influenced by epigenetic mechanisms.
Yitong Lu +6 more
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Innovative psychological treatments for depression [PDF]
, 2016 A number of high-intensity psychosocial interventions have been shown to be as efficacious as and more enduring than medications in the treatment of nonpsychotic depression. Moreover, there have been important advances in the development of strategies to
Hollon, Steven D. +1 more
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Clinical effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: the CoBalT randomised controlled trial [PDF]
, 2014 Background: Only one-third of patients with depression respond fully to treatment with antidepressant medication. However, there is little robust evidence to guide the management of those whose symptoms are 'treatment resistant'.<p></p> ...
Abel, Anna +22 more
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A Novel Application of Ketamine for Improving Perioperative Sleep Disturbances
Nature and Science of Sleep, 2021 Bijia Song, Junchao Zhu Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of ChinaCorrespondence: Junchao ZhuDepartment of Anesthesiology, Shengjing Hospital of China Medical University ...
Song B, Zhu J
doaj
Medicine Science, 2019 Pari-flo is a commercial preparation in the form of a solution containing standardized Passiflora incarnata plant extract. We hypothesized that Pari-flo may have antidepressant potential with its content.
Ismet Yilmaz, Ahmet Berk
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Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder. [PDF]
, 2019 Changes in gene expression (GE) during antidepressant treatment may increase understanding of the action of antidepressant medications and serve as biomarkers of efficacy.
Congdon, Eliza +6 more
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Citalopram plus low-dose pipamperone versus citalopram plus placebo in patients with major depressive disorder: an 8-week, double-blind, randomized study on magnitude and timing of clinical response [PDF]
, 2011 Background: Selective serotonin reuptake inhibitors take several weeks to achieve their full antidepressant effects. Post-synaptic 5-HT<sub>2A</sub> receptor activation is thought to be involved in this delayed therapeutic effect ...
A. F. Schatzberg +14 more
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Antidepressant drugs and the response in the placebo group: the real problem lies in our understanding of the issue [PDF]
, 2012 In a recent paper, Horder and colleagues (Horder et al., 2010, J Psychopharmacol 25: 1277–1288) have suggested that the mainproblem in the Kirsch analysis is methodological. We argue that the results are similar irrespective of the method used.
Bech P +8 more
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Signaling pathways linking behavior to neurogenesis in healthy brain and disease [PDF]
, 2020 Self-repair of the adult brain is limited – most diseases lack effective therapy. In order to better understand how a regenerative response can be achieved, studying mechanisms shaping the neurogenic niche, from environmental factors to intrinsic ...
Klempin, Friederike
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