Results 61 to 70 of about 253,402 (288)

Deep Brain Stimulation Induces Antidepressant Effects by Restoring High‐Fidelity Communication in the BNST‐NAc Circuit

Advanced Science, EarlyView.
This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv, Yu Cao, Yuhan Wang, Yunhao Wu, Yingying Zhang, Kuanghao Ye, Xian Qiu, Qingfang Sun, Liuguan Bian, Halimureti Paerhati, Valerie Voon, Shikun Zhan, Bomin Sun   +12 more
wiley   +1 more source

Could antidepressants increase mood and immunity at the same time?

Frontiers in Psychiatry
A review of scientific literature suggests that the use of antidepressants can be broadly extended to address various forms of stress and inflammation as an adjunctive therapy that enhances host resistance.
Francis Lavergne, Therese M. Jay
doaj   +1 more source

The reported use and effectiveness of Hypericum (St John’s wort) on affective symptoms in a depression self-help group [PDF]

, 2002
A recent meta-analysis suggested that Hypericum perforatum (St John’s wort) is an effective treatment for mild to moderate depression and may have a superior side-effect profile to some antidepressant drugs.
Baldwin, D.S., Dyson, R., Jenkins, G., Mayers, A.G., Tiernan, A.   +4 more
core   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Efficacy of Antidepressants in Depression in Breast Cancer: A Systematic Review and Meta-analysis

Journal of Psychiatry Spectrum
Background: Breast cancer is the most common malignancy in women worldwide. Depression is a common psychological issue among these patients as they experience significant stress, and it impacts their quality of life.
Vinuta C. Chikkamath, Lingaraj Kariyannavar, Ranganath Rattehalli, B. Srinivas Pai   +3 more
doaj   +1 more source

D-cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: a systematic review and meta-analysis of individual participant data [PDF]

, 2017
Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear.
Altemus, Margaret, Anderson, Page, Andersson, Erik, Cukor, Judith, Davis, Michael, DCS Anxiety Consortium, de Kleine, Rianne A., Difede, JoAnn, Dunlop, Boadie W., Farrell, Lara J., Fernández de la Cruz, Lorena, Finck, Claudia, Frumento, Paolo, Geffken, Gary R., Geller, Daniel, Gerardi, Maryrose, Golfels, Fabian, Goodman, Wayne K., Guastella, Adam J., Gutner, Cassidy, Hendriks, Gert-Jan, Heyman, Isobel, Hofmann, Stefan G., Jovanovic, Tanja, Kushner, Matt G., Lee, Francis S., Lenze, Eric J., Levinson, Cheri A., Lewin, Adam B., Mataix-Cols, David, McConnell, Harry, McNamara, Joseph P., Monzani, Benedetta, Murphy, Tanya K., Norrholm, Seth, Otto, Michael W., Plag, Jens, Pollack, Mark H., Pérez-Vigil, Ana, Ressler, Kerry J., Rodebaugh, Thomas L., Rosenfield, David, Rothbaum, Barbara O., Rück, Christian, Scheeringa, Michael S., Siewert-Siegmund, Anja, Smits, Jasper A.J., Storch, Eric A., Ströhle, Andreas, Tart, Candyce D., Thuras, Paul, Tolin, David F., van Minnen, Agnes, Waters, Allison M., Weems, Carl F., Wilhelm, Sabine, Wyka, Katarzyna   +56 more
core   +1 more source

Pharmacological mechanism of natural antidepressants: the role of epigenetic modifications

Frontiers in Pharmacology
MDD is a complex mental illness shaped by the interplay between genetic vulnerability and environmental triggers. Its underlying pathophysiological processes are now understood to be influenced by epigenetic mechanisms.
Yitong Lu, Ruirui Shang, Xia Zhong, Jingbo Shi, Guangheng Zhang, Weijie Zhao, Jing Teng   +6 more
doaj   +1 more source

Distinct Biotypes of Visual Perception in Major Depressive Disorder

Advanced Science, EarlyView.
In a discover dataset (272 acute MDD patients), this work identifies a novel depression biotype characterized by impaired visual motion perception, using machine learning clustering. An independent dataset confirms the robustness of this biotype through cross‐validation and demonstrates its generalizability.
Zhuoran Cai, Xi‐Wen Hu, Yuyang Li, Zheng Lin, Yongjie Li, Yong‐Chun Cai, Tao Xu, Ke Jia, Jin‐Fang Han, Zhong‐Lin Tan, Dezhong Yao, Xue Mei Song, Sugai Liang, Georg Northoff   +13 more
wiley   +1 more source

A study of leukocyte and platelet activity in patients with suicide attempt related to acute stres reaction

Psychiatry and Behavioral Sciences, 2013
Aim: Acute stress reaction (ASR) is often seen with depression, and stress-related hormones may play an important role in acute arterial thrombosis by increasing platelet aggregation.
Emel Kocer, Aytekin Alcelik, Gulşen Kocaman, Abdulkadir Kocer   +3 more
doaj   +1 more source

Facilitating Granule Cell Survival and Maturation in Dentate Gyrus With Baicalin for Antidepressant Therapeutics

Frontiers in Pharmacology, 2020
Baicalin isolated from Scutellaria baicalensis possesses antidepressant abilities through its relation to hippocampal neurogenesis. Current research has found that baicalin can promote the proliferation of hippocampal granule cells, however, the detailed
Fan Zhao, Weiwei Tao, Zhiyuan Shang, Weihua Zhang, Jie Ruan, Chenyiyu Zhang, Liping Zhou, Hunter Aiello, Hezheng Lai, Hezheng Lai, Rong Qu   +10 more
doaj   +1 more source