Results 61 to 70 of about 267,421 (217)
An electroencephalographic signature predicts antidepressant response in major depression
Nature Biotechnology, 2019 Antidepressants are widely prescribed, but their efficacy relative to placebo is modest, in part because the clinical diagnosis of major depression encompasses biologically heterogeneous conditions. Here, we sought to identify a neurobiological signature
Wei Wu +26 more
semanticscholar +1 more source
ANet: Autoencoder-Based Local Field Potential Feature Extractor for Evaluating An Antidepressant Effect in Mice after Administering Kratom Leaf Extracts [PDF]
arXiv, 2022 Kratom (KT) typically exerts antidepressant (AD) effects. However, evaluating which form of KT extracts possesses AD properties similar to the standard AD fluoxetine (flu) remained challenging. Here, we adopted an autoencoder (AE)-based anomaly detector called ANet to measure the similarity of mice's local field potential (LFP) features that responded ...
arxiv
GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions.
Journal of Clinical Investigation, 2019 A single sub-anesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients, addressing a major unmet need for the treatment of mood disorders.
Danielle M. Gerhard +11 more
semanticscholar +1 more source
Frontiers in Neuroscience, 2021 Major depressive disorder (MDD) is a debilitating mental illness affecting people worldwide. Although significant progress has been made in the development of therapeutic agents to treat this condition, fewer than half of all patients respond to ...
Yuan Zhang +13 more
doaj +1 more source
5-HT2A mediated plasticity as a target in major depression: a narrative review connecting the dots from neurobiology to cognition and psychology [PDF]
arXiv, 2020 As the world's first primary morbidity factor, depression has a considerable impact on both an individual as well as a societal level. despite their discovery several decades ago, classical antidepressants have been shown to provide limited benefits against this condition.
arxiv
Antidepressant effect of Gentiana olivieri Griseb. in male rats exposed to chronic mild stress
Libyan Journal of Medicine, 2020 Background: The flowering parts of Gentiana olivieri, known as ‘Afat’ in the southeastern Anatolia region of Turkey, are used as a tonic, an appetizer, and for the treatment of several mental disorders, including depression.
Ahmet Berk +5 more
doaj +1 more source
Animals, 2020 Animal welfare assessment requires measures for positive affective state. Pharmacological agents that manipulate affective state can be used to evaluate novel biomarkers for affective state assessment.
Laura E. Marsh +4 more
doaj +1 more source
Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism.
American Journal of Psychiatry, 2018 OBJECTIVE: In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces opioid system activation. The objective of this study was to determine whether opioid receptor antagonism prior to administration of intravenous ketamine attenuates its
N. Williams +10 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Depression is a global health problem with growing prevalence rates and serious impacts on the daily life of patients. However, the side effects of currently used antidepressants greatly reduce the compliance of patients.
Shen Chen +10 more
doaj +1 more source