Results 61 to 70 of about 276,787 (297)

Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1

Translational Psychiatry, 2020
In rodent models of depression, (R)-ketamine has greater potency and longer-lasting antidepressant effects than (S)-ketamine; however, the precise molecular mechanisms underlying the antidepressant actions of (R)-ketamine remain unknown.
Kai Zhang, Chun Yang, Lijia Chang, A. Sakamoto, Toru Suzuki, Yuko Fujita, Y. Qu, Siming Wang, Yaoyu Pu, Yunfei Tan, Xingming Wang, T. Ishima, Y. Shirayama, M. Hatano, Kenji F. Tanaka, K. Hashimoto   +15 more
semanticscholar   +1 more source

De‐Saturation of Single‐Atom Copper Catalysts for Accelerating Propargylic Substitution Reactions

Advanced Materials, EarlyView.
De‐saturation of copper‐based single‐atom catalysts (De‐sat SACs) are realized by a KOH‐mediated Joule thermal shock strategy. Benefiting from the under‐saturation coordination environment of single‐atom Cu center, De‐sat Cu SACs exhibit remarkable catalytic activity in propargylic substitution reactions, tolerating a broad range of nucleophiles (N–, C–
Qilong Cai, Yang Meng, Chao Wu, Wenjia Qu, Qiang Wang, Tan Li, Chengyi Liu, Jinxing Chen, Huihui Lin, Qian He, Yafei Zhao, Shibo Xi, Jiong Lu   +12 more
wiley   +1 more source

Surge in antidepressant usage among adolescents and young adults during the COVID-19 pandemic: insights from an interrupted time series analysis

Epidemiology and Psychiatric Sciences
Background Depressive disorders are a major public health issue in Western societies, particularly among adolescents, young adults and women. The COVID-19 pandemic has exacerbated mental health challenges, increasing depression and anxiety symptoms ...
Zeno Di Valerio, Daniela Fortuna, Marco Montalti, Lucia Alberghini, Anna Caterina Leucci, Alessio Saponaro, Elisa Sangiorgi, Elena Berti, Maurizia Rolli, Dario Tedesco   +9 more
doaj   +1 more source

Expression of monoamine transporters, nitric oxide synthase 3 and neurotrophin genes in antidepressant-stimulated astrocytes

Frontiers in Psychiatry, 2012
Background: There is increasing evidence that glial cells play a role in the pathomechanisms of mood disorders and the mode of action of antidepressant drugs.
Sarah eKittel-Schneider, Gunter eKenis, Julia eSchek, Daniel evan den Hove, Daniel evan den Hove, Jos ePrickaerts, Klaus Peter eLesch, Klaus Peter eLesch, Harry eSteinbusch, Andreas eReif   +9 more
doaj   +1 more source

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Plants, 2020
Crocus sativus, a medicinally important herbaceous plant, has been traditionally used to cure coughs, colds, insomnia, cramps, asthma, and pain. Moreover, the therapeutic applications of saffron include its immunomodulatory and anticancer properties. The
Asif Khan, Nur Airina Muhamad, Hammad Ismail, Abdul Nasir, Atif Ali Khan Khalil, Yasir Anwar, Zahid Khan, Amjad Ali, Rosna Mat Taha, Baker Al-Shara, Sara Latif, Bushra Mirza, Yousef Abdal Jalil Fadladdin, Isam Mohamed Abu Zeid, Saed Ayidh Al-Thobaiti   +14 more
doaj   +1 more source

Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism.

American Journal of Psychiatry, 2018
OBJECTIVE: In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces opioid system activation. The objective of this study was to determine whether opioid receptor antagonism prior to administration of intravenous ketamine attenuates its
N. Williams, Boris D Heifets, C. Blasey, K. Sudheimer, J. Pannu, Heather Pankow, J. Hawkins, J. Birnbaum, D. M. Lyons, C. Rodriguez, A. Schatzberg   +10 more
semanticscholar   +1 more source

Hemp Proteins Conjugated with Green Tea Polyphenol Extract Form De Novo Plant‐Sourced Emulsifiers Suitable for Nanodelivery Systems Bearing Lipophilic Psychopharmaceuticals

Advanced Therapeutics, EarlyView.
Green tea polyphenols, conjugated either covalently or non‐covalently to hemp protein, comprise an excellent stabilizing matrix for oxidatively‐sensitive small molecules. These nanoemulsions are highly stable to a variety of chemical and physical stressors, protecting the small molecule while allowing for easy uptake across cell membranes and rapid ...
William Charles Hosie, Abhinandan Banerjee, Mary Augustina Egbuta, Kasra Razmkhah, Behzad Bolandi, Khalilalrahman Dehvari, Anton Homon, Aleena Kappadakunnel, Jonathan J. Simone, John F. Trant   +9 more
wiley   +1 more source

Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway.

Frontiers in Pharmacology, 2015
The major drug binding site of sodium channels is inaccessible from the extracellular side, drug molecules can only access it either from the membrane phase, or from the intracellular aqueous phase.
Alexandra eLazar, Nora eLenkey, Krisztina ePesti, Krisztina ePesti, Laszlo eFodor, Arpad eMike   +5 more
doaj   +1 more source

Time‐Dependent Therapeutic Effect of S‐Ketamine on PTSD Mediated by VTA‐OFC Dopaminergic Neurocircuit

Advanced Science, EarlyView.
This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang, Lei Liu, Jinghao Wang, Jiannan Li, Huiming Li, Rui Wang, Hui Wang, Min Wang, Quanying Liu, Zhongmin Fan, Yunyun Zhang, Xinxin Zhang, Dan Wang, Sa Wang, Rou Xue, Jindong Mao, Min Cai, Pengfei Wei, Hailong Dong, Yumei Wu, Guangchao Zhao   +20 more
wiley   +1 more source

Chinese herbal medicines for the treatment of depression: a systematic review and network meta-analysis

Frontiers in Pharmacology
Objectives: Amidst rising global burden of depression and the associated challenges with conventional antidepressant therapies, there is a growing interest in exploring the efficacy and safety of alternative treatments. This study uses a Bayesian network
Chun Dang, Qinxuan Wang, Qian Li, Ying Xiong, Yaoheng Lu   +4 more
doaj   +1 more source