Results 71 to 80 of about 276,787 (297)

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

Could antidepressants increase mood and immunity at the same time?

Frontiers in Psychiatry
A review of scientific literature suggests that the use of antidepressants can be broadly extended to address various forms of stress and inflammation as an adjunctive therapy that enhances host resistance.
Francis Lavergne, Therese M. Jay
doaj   +1 more source

DRUG REPOSITIONING: Revisiting the basic psychopharmacological mechanism of action for agomelatine and where it should be classified?

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2019
Concerning Agomelatine, as of this present moment and deeply analyzing things from the psychopharmacological point of view, the utmost important question yet to be answered is “why should the drug Agomelatine be regarded as an antidepressant agent when ...
Olumuyiwa John Fasipe, Oluwatosin Beatrice Ibiyemi-Fasipe, Peter Ehizokhale Akhideno, Muyiwa Samuel Fageyinbo   +3 more
doaj   +1 more source

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Efficacy of Antidepressants in Depression in Breast Cancer: A Systematic Review and Meta-analysis

Journal of Psychiatry Spectrum
Background: Breast cancer is the most common malignancy in women worldwide. Depression is a common psychological issue among these patients as they experience significant stress, and it impacts their quality of life.
Vinuta C. Chikkamath, Lingaraj Kariyannavar, Ranganath Rattehalli, B. Srinivas Pai   +3 more
doaj   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Pharmacological mechanism of natural antidepressants: the role of epigenetic modifications

Frontiers in Pharmacology
MDD is a complex mental illness shaped by the interplay between genetic vulnerability and environmental triggers. Its underlying pathophysiological processes are now understood to be influenced by epigenetic mechanisms.
Yitong Lu, Ruirui Shang, Xia Zhong, Jingbo Shi, Guangheng Zhang, Weijie Zhao, Jing Teng   +6 more
doaj   +1 more source

Hyponatremia Secondary Treatment with SSRI Antidepressants in Adults and Elderly [PDF]

, 2022
Martin J Mazzoglio Y Nabar, Milagros M. Muniz, Christian A. Montivero, Gabriel Schraier, Emmanuel E Leidi Terren, Martin J Mazzoglio Y Nabar, Milagros M. Muniz, Christian A. Montivero, Gabriel Schraier, Emmanuel E Leidi Terren   +9 more
openalex   +1 more source

Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

Nature Communications, 2019
Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the therapeutic response produced by novel rapid-acting antidepressants such as ketamine are mediated by mPFC activity.
Brendan D. Hare, R. Shinohara, Rong‐jian Liu, Santosh Pothula, R. DiLeone, R. Duman   +5 more
semanticscholar   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source