Results 71 to 80 of about 254,619 (233)

Peripheral Etanercept Administration Normalizes Behavior, Hippocampal Neurogenesis, and Hippocampal Reelin and GABAA Receptor Expression in a Preclinical Model of Depression

Frontiers in Pharmacology, 2018
Depression is a serious psychiatric disorder frequently comorbid with autoimmune disorders. Previous work in our lab has demonstrated that repeated corticosterone (CORT) injections in rats reliably increase depressive-like behavior, impair hippocampal ...
Kyle J. Brymer, Erin Y. Fenton, Lisa E. Kalynchuk, Hector J. Caruncho   +3 more
doaj   +1 more source

Antidepressant use associated with increased risk of hip fracture in the older population [PDF]

, 2017
Commentary on: Torvinen-Kiiskinen S, Tolppanen AM, Koponen M, et al. Antidepressant use and risk of hip fractures among community-dwelling persons with and without Alzheimer's disease. Int J Geriatr Psychiatry 2017. doi: 10.1002/gps.4667.
Kennedy, Michelle
core   +1 more source

Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway.

Frontiers in Pharmacology, 2015
The major drug binding site of sodium channels is inaccessible from the extracellular side, drug molecules can only access it either from the membrane phase, or from the intracellular aqueous phase.
Alexandra eLazar, Nora eLenkey, Krisztina ePesti, Krisztina ePesti, Laszlo eFodor, Arpad eMike   +5 more
doaj   +1 more source

Telomere length as a predictor of response to Pioglitazone in patients with unremitted depression: a preliminary study. [PDF]

, 2016
We studied peripheral leukocyte telomere length (LTL) as a predictor of antidepressant response to PPAR-γ agonist in patients with unremitted depression.
Blackburn, E, Epel, E, Lin, J, Lin, KW, Rasgon, N   +4 more
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Antidepressant drugs and the response in the placebo group: the real problem lies in our understanding of the issue [PDF]

, 2012
In a recent paper, Horder and colleagues (Horder et al., 2010, J Psychopharmacol 25: 1277–1288) have suggested that the mainproblem in the Kirsch analysis is methodological. We argue that the results are similar irrespective of the method used.
Bech P, Fountoulakis KN, Hans-Jürgen Möller, Kirsch I, Kirsch I, Kirsch I, Konarski JZ, Konstantinos N Fountoulakis, Moncrieff J   +8 more
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Practical Advice for Primary Care Clinicians on the Safe and Effective Use of Vortioxetine for Patients with Major Depressive Disorder (MDD)

Neuropsychiatric Disease and Treatment, 2022
C Brendan Montano,1,2 W Clay Jackson,3,4 Denise Vanacore,5 Richard H Weisler6,7 1Montano Wellness LLC, Cromwell, CT, USA; 2Department of Family Medicine, University of Connecticut Medical School, Farmington, CT, USA; 3Department of Psychiatry and Family ...
Montano CB, Jackson WC, Vanacore D, Weisler RH   +3 more
doaj  

Antidepressant Potential of Lotus corniculatus L. subsp. corniculatus: An Ethnobotany Based Approach

Molecules, 2020
As a Turkish traditional medicinal plant, aerial parts of Lotus corniculatus L. subsp. corniculatus (Fabaceae) are used as a painkiller, antihemoroidal, diuretic and sedative. In this study, the antidepressant potential of the plant has been attempted to
Fatma Tuğçe Gürağaç Dereli, Haroon Khan, Eduardo Sobarzo-Sánchez, Esra Küpeli Akkol   +3 more
doaj   +1 more source

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression [PDF]

, 2012
Background: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
A Cipriani, A Cipriani, A Hrobjartsson, A Loh, Andrea Pfennig, BR Rutherford, CP Gross, DE Moerman, DL Sackett, EA Largent, Emanuel Severus, F Seemuller, FG Miller, Florian Seemüller, G Parker, GI Papakostas, H Brody, H Brody, Hans-Jürgen Möller, HJ Moller, HJ Moller, HJ Moller, HU Wittchen, HV Krell, J Odgaard-Jensen, L Colloca, L Colloca, M Sinyor, MA Posternak, ME Wechsler, Michael Bauer, Michael Berger, Michael Obermeier, Michael Riedel, R Jones, RE Drake, RW Lam, Sandra Dittmann, SB Patten, SH Kennedy, Sophia Frangou, SR Wisniewski, U Hegerl, U Hegerl   +43 more
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Escitalopram versus paroxetine controlled release in major depressive disorder: a randomized trial

Neuropsychiatric Disease and Treatment, 2017
Taro Kishi,1 Yuki Matsuda,1 Shinji Matsunaga,1 Masatsugu Moriwaki,1,2 Yoichiro Otake,2 Kaku Akamatsu,3 Tomo Okochi,4 Shigeki Hirano,4 Toshihiko Funahashi,5 Momoko Okuda,6 Hideaki Tabuse,6 Kiyoshi Fujita,2 Nakao Iwata1 1Department of Psychiatry, Fujita ...
Kishi T, Matsuda Y, Matsunaga S, Moriwaki M, Otake Y, Akamatsu K, Okochi T, Hirano S, Funahashi T, Okuda M, Tabuse H, Fujita K, Iwata N   +12 more
doaj  

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
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