Results 81 to 90 of about 253,402 (288)

The pharmacological management of depression – Update 2017

South African Family Practice, 2017
Depression affects nearly 350 million people worldwide. Local data indicates that approximately 17% of all South Africans will experience at least one episode of depression in their lifetime.
Elzbieta Osuch, Andre Marais
doaj   +1 more source

A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis

Animal Models and Experimental Medicine, EarlyView.
A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu, Yafei Yang, Chunxi Liu, Danting Wen, Tingyu Zhao, Ping Xie, Jing Xiao   +6 more
wiley   +1 more source

Synergistic Effects of Ginsenoside Rb3 and Rc From Panax notoginseng Leaf on Alleviating Neuroinflammation via PACAP in Depression

Food Frontiers
Panax notoginseng Leaf (PNL), an edible‐medicinal botanical resource, shows potential as functional ingredients for alleviating depression, owing to their unique saponin composition.
Shu‐zhen Ran, Rui Peng, Qin‐wan Guo, Li‐juan Ma, Jian‐bo Wan, Jun‐qing Huang, Zi‐ying Wang, Gang Chen   +7 more
doaj   +1 more source

Aldose Reductase Inhibition by Orthosiphon stamineus Extracts and Constituents Suggests Antioxidant Potential

Molecules
Background/Objectives: Aldose reductase (AR) plays a crucial role in the accumulation of oxidative factors that lead to oxidative stress-related neuroinflammation. This study aims to find a novel agent from natural sources that can inhibit AR.
Yousaf Dawood, Atheer Zgair, Mun Fei Yam, Nur Hidayah Kaz Abdul Aziz   +3 more
doaj   +1 more source

ASSESSMENT OF SOME NEUROPHARMACOLOGICAL POTENTIAL OF METHANOL SEED EXTRACT OF HUNTERIA UMBELLATA IN EXPERIMENTAL ANIMAL MODELS [PDF]

Science Heritage Journal
This study evaluated the anxiolytic, sedative, antidepressant, and anticonvulsant effects of the methanol seed extract of Hunteria umbellata in mice using established experimental models, including the Elevated Plus Maze (EPM), Hole-board test, Rota-rod ...
James Odianosen, Oseyomon, Godswill, Ohiozua, Philip Akugbe, Obarisiagbon, Abigail Mebu, Akhigbemen, Sylvia, Iyoha, Uati Victory, Usifo, Winner, Ebhounaye, Stella Ndidiamaka, Nwaoke   +7 more
doaj   +1 more source

Scalp electroacupuncture targeting trigeminal nerve activation alleviates post‐traumatic stress disorder–induced depression and neuroinflammation in mice

Animal Models and Experimental Medicine, EarlyView.
Scalp electroacupuncture (SA) through activation of the trigeminal pathway exerts anti‐inflammatory, antidepressant, and anxiolytic effects in an animal model of post‐traumatic stress disorder induced by single prolonged stress. This suggests that SA is involved in neuroinflammation and changes in brain‐derived neurotrophic factor protein through the ...
Bombi Lee, Yoongeum Kim, Hyungjun Kim, Dae‐Hyun Hahm   +3 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Antidepressants versus interpersonal psychotherapy in treating depression in HIV-positive patients.

South African Journal of Psychiatry, 2012
Aim. Despite the prevalence of HIV and AIDS in South Africa reaching pandemic proportions, very few studies have been published on co-morbid depression. This study at Chris Hani Baragwanath Hospital was conducted on a group of HIV-positive patients with ...
M Y H Moosa, F Y Jeenah
doaj   +1 more source

Disclosure of Clinical Trial Data: Why Exemption 4 of the Freedom of Information Act Should Be Restored [PDF]

, 2005
Clinical trial data generated during the FDA drug approval process can be very valuable. While patients and doctors desperately need this information to make informed choices about medical treatment, drug sponsors strive to keep this resource secret to ...
Boyce, Janene
core   +2 more sources

Combining antidepressants.

Shanghai archives of psychiatry, 2014
Treatment-resistant depression is a common problem encountered by psychiatrists. These patients are often difficult to treat effectively. Strategies for addressing patients with treatment-resistant depression include changing medications, adding another antidepressant (antidepressant polypharmacy), and augmenting treatment with a non-antidepressant.
openaire   +2 more sources