Results 81 to 90 of about 267,421 (217)
Molecules, 2019 The currently available antidepressant agents necessitate the development of newer alternatives because of their serious adverse effects and costs. Traditional medicinal knowledge is likely the key that opens the door to discover new medicines.
Esra Küpeli Akkol +2 more
doaj +1 more source
Antidepressant drug effects and depression severity: a patient-level meta-analysis.
Journal of the American Medical Association (JAMA), 2010 CONTEXT Antidepressant medications represent the best established treatment for major depressive disorder, but there is little evidence that they have a specific pharmacological effect relative to pill placebo for patients with less severe depression ...
J. Fournier +6 more
semanticscholar +1 more source
Hypericin: Single molecule spectroscopy of an active natural ingredient [PDF]
, 2019 Hypericin can be found in nature in Hypericum perforatum (St. John's Wort) and has become subject of intense biochemical research. Studies report of antidepressive, antineoplastic, antitumor and antiviral activity of hypericin. Among the variety of potential applications hypericin can be used as photosensitizer in photodynamic therapy (PDT), where it ...
arxiv +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Standard antidepressant treatments require weeks to show effectiveness. A single subanesthetic dose of ketamine rapidly attenuates many clinical signs and symptoms of depression; however, ketamine treatment also has many adverse effects ...
E. Lumsden +20 more
semanticscholar +1 more source
Alpha Wavelet Power as a Biomarker of Antidepressant Treatment Response in Bipolar Depression [PDF]
arXiv, 2017 There is mounting evidence of a link between the properties of electroencephalograms (EEGs) of depressive patients and the outcome of pharmacotherapy. The goal of this study was to develop an EEG biomarker of antidepressant treatment response which would require only a single EEG measurement.
arxiv
Analytical methods for determination of selective serotonin reuptake inhibitor antidepressants
Reviews in Analytical Chemistry, 2011 Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression. SSRIs are classified as fluoxetine, paroxetine, escitalopram, citalopram, sertraline, and fluvoxamine.
Şentürk Zühre +2 more
doaj +1 more source
Association of Antidepressant Use With Adverse Health Outcomes: A Systematic Umbrella Review.
JAMA psychiatry, 2019 Importance Antidepressant use is increasing worldwide. Yet, contrasting evidence on the safety of antidepressants is available from meta-analyses, and the credibility of these findings has not been quantified.
E. Dragioti +16 more
semanticscholar +1 more source
A Skew Normal Model of the Dose-Effect Relation in Pharmacology [PDF]
arXiv, 2015 This paper deals with a skew-normal model of the relation between a dose $d > 0$ and a quantitative measure $E(d)$ of an effect of the administered drug. Precisely, $E(d)$ is a measure of the therapeutic response or a measure of a side-effect. Some existing and additional properties of the logistic functions are proved, and a skew-normal model of the ...
arxiv
Translational Psychiatry, 2019 Although the robust antidepressant effects of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine in patients with treatment-resistant depression are beyond doubt, the precise molecular and cellular mechanisms underlying its antidepressant ...
Chun Yang +3 more
semanticscholar +1 more source
(2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Despite available medications for depression, currently approved antidepressants take months to exert therapeutic effects, and ∼30% of patients remain treatment resistant.
P. Zanos +10 more
semanticscholar +1 more source