Results 61 to 70 of about 191,413 (246)
A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data
Advanced Science, EarlyView.SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang +5 more
wiley +1 more source
KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID‐ACTING ANTIDEPRESSANTS
Depression and Anxiety, 2016 Major depressive disorder (MDD) is a common and debilitating psychiatric disorder. Traditional antidepressants are of limited efficacy and take weeks to months to yield full therapeutic effects.
C. Abdallah +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv +12 more
wiley +1 more source
Translational PsychiatryObjective Gastrointestinal adverse effects are the most commonly reported adverse effects associated with the use of antidepressants. While existing studies on the gastrointestinal effects of antidepressant medications offer valuable insights, there are ...
Sixiang Wen +8 more
doaj +1 more source
Is the Risk of Preterm Birth and Low Birth Weight Affected by the Use of Antidepressant Agents during Pregnancy? A Population-Based Investigation. [PDF]
PLoS ONE, 2016 Untreated depression during pregnancy increases the risk of morbidity and mortality in the mother and child. Therefore, specific treatments are required for this population.The study aimed to investigating the effect of antidepressant medication used ...
Anna Cantarutti +4 more
doaj +1 more source
Advanced Science, EarlyView.Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan +11 more
wiley +1 more source
Mutation in the TRKB cholesterol recognition site that blocks antidepressant binding does not influence the basal or BDNF-stimulated activation of TRKB [PDF]
, 2022 Caroline Biojone +6 more
openalex +1 more source
Journal of Affective Disorders, 2015 BACKGROUND Dose equivalence of antidepressants is critically important for clinical practice and for research. There are several methods to define and calculate dose equivalence but for antidepressants, only daily defined dose and consensus methods have ...
Y. Hayasaka +8 more
semanticscholar +1 more source
Distinct Biotypes of Visual Perception in Major Depressive Disorder
Advanced Science, EarlyView.In a discover dataset (272 acute MDD patients), this work identifies a novel depression biotype characterized by impaired visual motion perception, using machine learning clustering. An independent dataset confirms the robustness of this biotype through cross‐validation and demonstrates its generalizability.
Zhuoran Cai +13 more
wiley +1 more source