Results 81 to 90 of about 391,178 (335)
Advanced Science, EarlyView.Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou +16 more
wiley +1 more source
Autophagy-based antidepressants? [PDF]
Brazilian Journal of Psychiatry, 2023 Flávio Kapczinski +4 more
doaj +1 more source
Could antidepressants increase mood and immunity at the same time?
Frontiers in PsychiatryA review of scientific literature suggests that the use of antidepressants can be broadly extended to address various forms of stress and inflammation as an adjunctive therapy that enhances host resistance.
Francis Lavergne, Therese M. Jay
doaj +1 more source
KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID‐ACTING ANTIDEPRESSANTS
Depression and Anxiety, 2016 Major depressive disorder (MDD) is a common and debilitating psychiatric disorder. Traditional antidepressants are of limited efficacy and take weeks to months to yield full therapeutic effects.
C. Abdallah +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang +20 more
wiley +1 more source
Angewandte Chemie, EarlyView.Dendritic pillar[6]arenes encompass a new class of cavitands with planar chirality, unique binding pockets, and great water solubility. These easily accessible hosts permit differentiating racemic dexamisole from levamisole as known cocaine adulterants.
Nitesh Kumar +8 more
wiley +2 more sources
Are bank employees stressed? job perception and positivity in the banking sector: an italian observational study [PDF]
, 2018 Background: The epidemiology of stress on bank workers in Europe is only at the introductory stages. This study investigated for the first time the association between occupational stress level in bank-employees using the BEST8, Karasek-Model and socio ...
DE SIO, Simone +6 more
core +2 more sources
Barriers and facilitators to GP-patient communication about emotional concerns in UK primary care: a systematic review. [PDF]
, 2020 Background In the UK, general practitioners (GPs) are the most commonly used providers of care for emotional concerns. Objective To update and synthesize literature on barriers and facilitators to GP–patient communication about emotional concerns in
Byng, R. +4 more
core +4 more sources
Advanced Science, EarlyView.Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang +16 more
wiley +1 more source
Disclosure of Clinical Trial Data: Why Exemption 4 of the Freedom of Information Act Should Be Restored [PDF]
, 2005 Clinical trial data generated during the FDA drug approval process can be very valuable. While patients and doctors desperately need this information to make informed choices about medical treatment, drug sponsors strive to keep this resource secret to ...
Boyce, Janene
core +2 more sources