Overstated association between adolescent physical fitness and adulthood depression risk due to familial factors. [PDF]
J Intern MedAbstract Objective Examine the association between adolescent cardiorespiratory fitness and future risk of depression and dispensation of antidepressants, including the role of familial confounding. Methods A cohort study with sibling‐comparisons based on Swedish men who participated in mandatory military conscription examinations from 1972 to 1995 ...
Ballin M +4 more
europepmc +2 more sources
Lithium Augmentation in Treatment-Resistant Depression: A Qualitative Review of the Literature. [PDF]
PharmacotherapyABSTRACT Depression is the leading cause of disability worldwide, affecting people of all ages. Both pharmacological and non‐pharmacological therapies are available for its treatment. However, some patients do not respond to first‐line pharmacological interventions, referred to as treatment‐resistant depression (TRD).
Acero-González A +8 more
europepmc +2 more sources
Antidepressant drugs and the response in the placebo group: the real problem lies in our understanding of the issue [PDF]
, 2012 In a recent paper, Horder and colleagues (Horder et al., 2010, J Psychopharmacol 25: 1277–1288) have suggested that the mainproblem in the Kirsch analysis is methodological. We argue that the results are similar irrespective of the method used.
Bech P +8 more
core +1 more source
Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance. [PDF]
, 2014 Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed
Bordbar, Aarash +4 more
core +2 more sources
Insuficiência Hepática Aguda Induzida pela Trazodona e Diazepam [PDF]
, 2016 Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the
Barroso, E +5 more
core +1 more source
Clinical relevance and treatment possibilities of bipolar rapid cycling [PDF]
, 2002 Bipolar rapid cycling (RC) is defined as 4 or more affective episodes within 1 year. It has been postulated that RC is related to a poor response to lithium, to the same extent as mixed episodes or other atypical symptoms of the illness.
Amann, B. +3 more
core +1 more source
PET studies of the serotonin system in major depression and its treatment [PDF]
, 2014 The serotonin system has been implicated in major depression since the 1960s, mainly based on the serotonin enhancing properties of antidepressants.
Tiger, Mikael
core +1 more source
Smoking and antidepressants pharmacokinetics: a systematic review [PDF]
, 2017 Despite an increasingly recognized relationship between depression and smoking, little is known about how smoking influences antidepressant response and treatment outcomes.
Donato, H +3 more
core +1 more source
Cost-effectiveness analysis of pharmaceutical treatment options in the first-line management of major depressive disorder in Belgium [PDF]
, 2014 The objective of this study was to assess the cost effectiveness of commonly used antidepressants as first-line treatment of major depressive disorder (MDD) in Belgium.
Annemans, Lieven +5 more
core +2 more sources
Automatic summarization of MEDLINE citations for evidence-based medical treatment: A topic-oriented evaluation [PDF]
, 2008 As the number of electronic biomedical textual resources increases, it becomes harder for physicians to find useful answers at the point of care. Information retrieval applications provide access to databases; however, little research has been done on ...
Fiszman, Marcelo +3 more
core +1 more source