Results 31 to 40 of about 4,667 (141)

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Psychedelics Promote Structural and Functional Neural Plasticity. [PDF]

, 2018
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast ...
Barragan, Eden V, Burbach, Kyle F, Cameron, Lindsay P, Dennis, Megan Y, Duim, Whitney C, Gray, John A, Greb, Alexandra C, Ly, Calvin, McAllister, A Kimberley, Olson, David E, Ori-McKenney, Kassandra M, Paddy, Michael R, Soltanzadeh Zarandi, Sina, Sood, Alexander, Wilson, Paige C, Wong, Jonathan M   +15 more
core   +2 more sources

The Prevalence and Implications of Polypharmacy in Individuals With Type 1 Diabetes

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 696-702, March 2026.
Polypharmacy is increasingly recognized as a relevant issue in diabetes care, but its prevalence and clinical relevance in individuals with type 1 diabetes remain underexplored. This study aimed to determine the prevalence of polypharmacy and to identify associated clinical and psychological factors. Participants were recruited from a tertiary diabetes
Namam Ali, Stephan van Erp, Cornelis Kramers, Cornelis J. Tack, Bastiaan E. de Galan   +4 more
wiley   +1 more source

Biochemical and Physiological Effects of Galanin in Health and Disease

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles, Yubo Wang, Kathryn Rhodes, Sharon DeMorrow   +3 more
wiley   +1 more source

Alternanthera philoxeroides (Mart.) Griseb Mitigates Age‐Related Depression in Mice Through Regulation of Oxidative Stress and Neurogenic Mechanisms

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.
Depression adversely impacts daily life, with age‐related neurodegeneration being a significant contributing factor. Neurodegenerative alterations, often accelerated by oxidative stress, underlie depressive progression in advanced age. Our previous research has reported that Alternanthera philoxeroides (Mart.) Griseb (AP) exhibits promising antioxidant
Possatorn Aon-im, Orawan Monthakantirat, Yaowared Chulikhit, Supawadee Daodee, Chantana Boonyarat, Anake Kijjoa, Charinya Khamphukdee, Anjali Chauhan   +7 more
wiley   +1 more source

Which placebo to cure depression? A thought-provoking network meta-analysis [PDF]

, 2013
BACKGROUND: Antidepressants are often considered to be mere placebos despite the fact that meta-analyses are able to rank them. It follows that it should also be possible to rank different placebos, which are all made of sucrose.
Anne Solène Maria, Bruno Falissard, Bruno Millet, Florian Naudet, Jean Michel Reymann, Philippe Charlier   +5 more
core   +3 more sources

Biodegradable Films Incorporated With Peels of Jatobá (Hymenaea courbaril L.) and Pomegranate Fruit (Punica granatum L.) Extracts for Preserving Chicken Breast Fillets

Journal of Food Safety, Volume 45, Issue 6, December 2025.
First the pomegranate and jatobá peel extracts were obtained and phenolic compounds were determined by HPLC. Then, chitosan‐based films incorporated with extracts were prepared and applied to chicken breast fillet preservation. The fillets were stored at 4°C for 21 days and analyzed every 3 days for physicochemical and microbiological properties ...
Larissa Almeida Soares, Luciana Cristina Lins de Aquino Santana   +1 more
wiley   +1 more source

The Predominant Protective Effect of Tianeptine Over Other Antidepressants in Models of Neuronal Apoptosis: The Effect Blocked by Inhibitors of MAPK/ERK1/2 and PI3-K/Akt Pathways [PDF]

, 2013
Tianeptine (Tian) possesses neuroprotective potential, however, little is known about the effect of this drug in models of neuronal apoptosis. In the present study, we aimed (1) to compare the neuroprotective capacities of some antidepressants (ADs) in ...
D. Jantas, S. Krawczyk, W. Lason
core   +1 more source

High Prevalence of Psychological Symptoms, Sexual Dysfunction, and Prolonged Medical Leave Two Years After Acute Leukemia Diagnosis—Patient Reported Outcome in Sweden

eJHaem, Volume 6, Issue 5, October 2025.
ABSTRACT Introduction With the purpose of identifying unmet needs of patients with acute leukemia, survivors were identified from the Swedish National Acute Leukemia registries. Methods At six months and at two years from diagnosis, patients were requested by mail to report outcome with focus on depression, sick leave, and sexual dysfunction.
Emma Bergfelt Lennmyr, Anna Lübking, Marie Abrahamsson, Gunnar Juliusson, Martin Höglund, Heléne Hallböök   +5 more
wiley   +1 more source

Olanzapine / fluoxetine combination for treatment resistant depression : efficacy and clinical utility

, 2008
Antidepressant monotherapy is a first-line treatment for depression; however, not all sufferers will adequately respond to treatment. When treating a patient with treatment-resistant depression, the clinician needs to consider all factors which may ...
Beasley, Beasley, Berk, Berk, Berk, Brent, Brent, Brown, Bull, Burrows, Bymaster, Bymaster, Callaghan, Corya, Corya, Corya, Crown, DeVane, Dodd, Dube, Dunner, Gharabawi, Girgis, Goethe, Gossen, Huang, Jensen, Kapczinski, Keck, Lau, Lecrubier, McIntyre, Michael Berk, Moller, Nemeroff, Ng, Ostroff, Owens, Pasco, Rothschild, Seetal Dodd, Sheline, Shelton, Shi, Souery, Thase, Trivedi, Zanarini   +47 more
core   +1 more source