Results 31 to 40 of about 3,166 (75)

Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline

British Journal of Pharmacology, Volume 182, Issue 7, Page 1466-1486, April 2025.
Background and Purpose Alterations in tryptophan‐kynurenine (TRP‐KYN) pathway are implicated in major depressive disorder (MDD). α7 nicotinic acetylcholine (α7nACh) receptor regulates the hypothalamic–pituitary–adrenal (HPA) axis. We have shown that deficiency of kynurenine 3‐monooxygenase (KMO) induces depression‐like behaviour via kynurenic acid ...
Masaya Hasegawa, Kazuo Kunisawa, Bolati Wulaer, Hisayoshi Kubota, Hitomi Kurahashi, Takatoshi Sakata, Honomi Ando, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Taku Nagai, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Alleviation of Microglia Mediating Hippocampal Neuron Impairments and Depression‐Related Behaviors by Urolithin B via the SIRT1‐FOXO1 Pathway

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
UB exerts antidepressant activity and its modulation of microglia activation and neuroinflammation, balanced M1/M2 polarization via the SIRT1‐FOXO1 axis. ABSTRACT Aims Conventional antidepressants exhibit limited efficacy and delayed onset. This study aimed to elucidate the antidepressant effects of urolithin B (UB) and its regulatory role in microglia‐
Cuilan Liu, Di Zhao, Guoxing Yu, HengWei Du, Lihong Xu, Yifan Cao, Minghu Cui, Wentao Wang, Dan Wang, Jing Liu, Fantao Meng, Fengai Hu, Wei Li, Jing Du, Chen Li   +14 more
wiley   +1 more source

Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis

Orthopaedic Surgery, Volume 17, Issue 3, Page 922-938, March 2025.
This study employed transcriptomic analysis and Mendelian randomization to identify diagnostic and therapeutic biomarkers associated with aging‐circadian rhythm in knee osteoarthritis. Further functional and molecular mechanism analyses were conducted to elucidate their roles in knee osteoarthritis, providing a theoretical basis for clinical diagnosis ...
Hao Li, Yuze Yang, Bo Li, Jiaju Yang, Pengyu Liu, Yuanpeng Gao, Min Zhang, Guangzhi Ning   +7 more
wiley   +1 more source

Contribution of physiological dynamics in predicting major depressive disorder severity

Psychophysiology, Volume 62, Issue 2, February 2025.
Abstract This study aimed to explore the physiological dynamics of cognitive stress in patients with Major Depressive Disorder (MDD) and design a multiparametric model for objectively measuring severity of depression. Physiological signal recordings from 40 MDD patients and 40 healthy controls were collected in a baseline stage, in a stress‐inducing ...
Esther García Pagès, Spyridon Kontaxis, Sara Siddi, Mar Posadas‐de Miguel, Concepción de la Cámara, Maria Luisa Bernal, Thais Castro Ribeiro, Pablo Laguna, Llorenç Badiella, Raquel Bailón, Josep Maria Haro, Jordi Aguiló   +11 more
wiley   +1 more source

Nicorandil Ameliorates Depression‐Like Behaviors After Traumatic Brain Injury by Suppressing Ferroptosis Through the SLC7A11/GPX4 Axis in the Hippocampus

Brain and Behavior, Volume 15, Issue 1, January 2025.
Nicorandil administration significantly attenuates depression‐like behavior in rats with TBI. Mechanistically, nicorandil suppresses ferroptosis via promoting the SLC7A11/GPX4 axis in the hippocampus of rats with TBI, thus ameliorating depression‐like symptoms induced by TBI. Nicorandil: Nic.
Yao‐Ran Tu, Ming Tan, Yao Li, De‐Quan Hong, Fan Niu   +4 more
wiley   +1 more source

Evaluating the effects of physical activity and antidepressive agents on depressive symptoms in older adults: a meta-analysis of existing evidence. [PDF]

BMC Geriatr
Zhang S, Miao C.
europepmc   +1 more source

Recorded spontaneous seizure prior to electroconvulsive therapy after etomidate induction in a patient treated with bupropion: a case report. [PDF]

Neuropsychiatr
Pircher Nöckler ER, Mauracher L, Gasteiger L, Blasko I.   +3 more
europepmc   +1 more source

Dextromethorphan Bupropion Combination Tablet Suicide Attempt by Overdose: A Case Report. [PDF]

Neuropsychopharmacol Rep
Greer D, Girgis J, Kashani J, Atherton J.   +3 more
europepmc   +1 more source

Inhaled sevoflurane use for myoclonic status secondary to bupropion intoxication. [PDF]

Crit Care Sci
Canasiro AR, Park M, Cardozo Junior LCM, Vilar GR, Hajjar LA.   +4 more
europepmc   +1 more source

Prescribing Trends for Bipolar Disorder Drugs in Alberta, Canada Between 2008 and 2021: Tendances en matière de prescription de médicaments pour le trouble bipolaire en Alberta, au Canada, entre 2008 et 2021. [PDF]

Can J Psychiatry
Shafiq S, Ronksley PE, Elliott MJ, Bulloch AGM, Patten SB.   +4 more
europepmc   +1 more source