Results 11 to 20 of about 5,787 (193)

Ferulic acid as a therapeutic agent in depression: Evidence from preclinical studies

CNS Neuroscience &Therapeutics, Volume 29, Issue 9, Page 2397-2412, September 2023., 2023
Abstract Depression is a common but severe mood disorder with a very high prevalence across the general population. Depression is of global concern and poses a threat to human physical and mental health. Ferulic acid (FA) is a natural active ingredient that has antioxidative, anti‐inflammatory, and free radical scavenging properties.
Xiaoyu Dong, Dongxue Zhao
wiley   +1 more source

Lepidium meyenii Walp (Maca)‐derived extracellular vesicles ameliorate depression by promoting 5‐HT synthesis via the modulation of gut–brain axis

iMeta, Volume 2, Issue 3, August 2023., 2023
We successfully isolated Maca‐EVs using ultracentrifugation and tested its antidepressant effects in the unpredictable chronic mild stress mice. Maca‐EVs increased serum serotonin (5‐HT) levels probably via the gut microbiota and metabolism modulation.
Rui Hong, Lan Luo, Liang Wang, Zhao‐Li Hu, Qi‐Rong Yin, Ming Li, Bin Gu, Bin Wang, Tao Zhuang, Xin‐Yue Zhang, Yuan Zhou, Wan Wang, Lin‐Yan Huang, Bing Gu, Su‐Hua Qi   +14 more
wiley   +1 more source

Increased risk of depression after Guillain‐Barré syndrome

Muscle &Nerve, Volume 67, Issue 6, Page 497-505, June 2023., 2023
Abstract Introduction/Aims Guillain‐Barré syndrome (GBS) is a potentially life‐threatening disorder, and some patients may develop subsequent depression related to traumatic stress or permanent loss of motor function. We determined the short‐term (0 to 2 years) and long‐term (>2 years) risk of depression after GBS.
Lotte Sahin Levison, Reimar Wernich Thomsen, Henning Andersen   +2 more
wiley   +1 more source

Novel drug developmental strategies for treatment‐resistant depression

British Journal of Pharmacology, Volume 179, Issue 6, Page 1146-1186, March 2022., 2022
Major depressive disorder is a leading cause of disability worldwide. Because conventional therapies are ineffective in many patients, novel strategies are needed to overcome treatment‐resistant depression (TRD). Limiting factors of successful drug development in the last decades were the lack of (1) knowledge of pathophysiology, (2) translational ...
Éva Borbély, Mária Simon, Eberhard Fuchs, Ove Wiborg, Boldizsár Czéh, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Antidepressant use and stroke or mortality risk in the elderly

European Journal of Neurology, Volume 29, Issue 2, Page 469-477, February 2022., 2022
In real‐world data of the elderly population, it was found that the risk of experiencing stroke or death in antidepressant users during and up to 1 year after exposure was higher compared to non‐users, even after adjustment for possible confounders. Abstract Background and purpose Current evidence on antidepressant‐related stroke or mortality risk is ...
Begüm Irmak Ön, Xavier Vidal, Ursula Berger, Mònica Sabaté, Elena Ballarín, Olga Maisterra, Antonio San‐Jose, Luisa Ibáñez   +7 more
wiley   +1 more source

[Retracted] Affective Antidepressant, Cytotoxic Activities, and Characterization of Phyto‐Assisted Zinc Oxide Nanoparticles Synthesized Using Sanvitalia procumbens Aqueous Extract

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
Green synthesis of nanoparticles has emerged as an effective and environmentally friendly method. Therefore, the current investigation is based on the green synthesis of zinc oxide nanoparticles (ZnO‐NPs) using plant extract of Sanvitalia procumbens (S. procumbens) that act as a capping and reducing agent. S.
Yasir Rashid, Fozia, Ijaz Ahmad, Nisar Ahmad, Madeeha Aslam, Amal Alotaibi, Shahid Ali Shah   +6 more
wiley   +1 more source

Effectiveness of a recent topical sialogogue in the management of drug-induced xerostomia [PDF]

, 2011
Objectives: Use of certain drugs is the most common aetiology of xerostomia. Systemic sialogogues provide a longer effect than topic ones, but also induce relevant side effects. Topical sialogogues, as malic acid, allow a safe use as they
Aguilar Salvatierra, Antonio, Gómez Moreno, Gerardo, Herrera, David, Martin-Piedra, M.A.   +3 more
core   +1 more source

Smoking and antidepressants pharmacokinetics: a systematic review [PDF]

, 2017
Despite an increasingly recognized relationship between depression and smoking, little is known about how smoking influences antidepressant response and treatment outcomes.
Donato, H, Madeira, N, Oliveira, P, Ribeiro, J   +3 more
core   +1 more source

Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]

, 2004
Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.
Baghai, Thomas C., Laakmann, G., Schule, C.   +2 more
core   +1 more source

Efficacy of Antidepressants in Management of Depressive Symptoms in Dementia: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Journal of Psychiatry Spectrum
Background: Dementia is associated with a complex array of neuropsychiatric manifestations which require consideration as they worsen the course of illness, especially in neurodegenerative etiologies.
R. Shantheri Pai, I. M. Shashikala, P. Hasitha Sudhakar   +2 more
doaj   +1 more source