Results 41 to 50 of about 56,664 (214)

Efficacy and safety of antidepressants for pain in older adults: A systematic review and meta‐analysis

open access: yesBritish Journal of Clinical Pharmacology, Volume 90, Issue 12, Page 3097-3118, December 2024.
Aims In many countries, pain is the most common indication for use of antidepressants in older adults. We reviewed the evidence from randomized controlled trials on the efficacy and safety of antidepressants, compared to all alternatives for pain in older adults (aged ≥65 years).
Sujita W. Narayan   +10 more
wiley   +1 more source

利用三碘甲狀腺氨酸強化療法治療對於三環抗抑鬱藥物無效的濫用藥物病人 [PDF]

open access: yes, 2001
We report on two substance misusers with depression resistant to tricyclic antidepressant treatment who responded to triiodothyronine augmentation.
Ho, TP, Kan, CK
core  

Comparative efficacy and acceptability of seven augmentation agents for treatment-resistant depression: A multiple-treatments meta-analysis [PDF]

open access: yes, 2014
Background. Treatment-resistant depression (TRD) is a therapeutic challenge for clinicians. Augmentation pharmacotherapy is effective for TRD, but it is still unclear which augmentation agent is most efficacious.  Objective.
Hong-Bo Qi, Shuai Huang, Xing Wang
core   +3 more sources

Ginsenoside Rg1: A Neuroprotective Natural Dammarane‐Type Triterpenoid Saponin With Anti‐Depressive Properties

open access: yesCNS Neuroscience &Therapeutics, Volume 30, Issue 12, December 2024.
Rg1 exhibits antidepressant effects through diverse mechanisms, such as anti‐inflammation, synaptic protection, neurogenesis promotion, brain‐derived neurotrophic factor release, enhancement of astrocyte gap junction function, and regulation of hypothalamic–pituitary–adrenal axis and antioxidative stress. Experimental studies validate Rg1's efficacy in
Dong Han   +5 more
wiley   +1 more source

Prevention of Tricyclic Antidepressant-Induced Ventricular Tachyarrhythmia by a Specific Bradycardic Agent in a Canine Model

open access: yesJournal of Cardiovascular Pharmacology, 1994
Sinus tachycardia facilitates ventricular conduction delay and sustained ventricular tachyarrhythmias during tricyclic antidepressant overdose. We hypothesized that impeding sinus tachycardia with the specific bradycardia agent, UL-FS 49, would reduce the incidence of ventricular tachyarrhythmia caused by tricyclic antidepressant overdose and tested ...
Steven D. Nelson   +2 more
openaire   +4 more sources

Coronary artery disease and depression [PDF]

open access: yes, 2017
Coronary artery disease (CAD) as well as depression are both highly prevalent diseases. Both cause a significant decrease in quality of life for the patient and impose a significant economic burden on society.
Langewitz, Wolf   +3 more
core  

Successful Suicide in a Child: Depression-Related or Paroxetine-Induced? [PDF]

open access: yes, 2017
Background: Children and adolescents are prone to develop psychiatric problems after stressful life events. These problems need appropriate treatment because of negative consequences like disease-related suicide.
Aghakhani, K   +3 more
core   +1 more source

A target trial emulation comparing the antidepressant effectiveness of selective serotonin reuptake inhibitors (SSRIs) highlighting the importance of patent‐related confounding by indication

open access: yesActa Psychiatrica Scandinavica, Volume 150, Issue 4, Page 198-208, October 2024.
Abstract Background The comparative effectiveness of selective serotonin reuptake inhibitors (SSRIs) has been subjected to relatively little research. However, a recent study based on target trial emulation suggested that sertraline may be more effective than escitalopram.
Christopher Rohde   +2 more
wiley   +1 more source

SERTRALINE AND MIRTAZAPINE AS GERIATRIC ANTIDEPRESSANTS [PDF]

open access: yes, 2013
Background: Depression within the geriatric patient population is an important issue as it is associated with increased mortality. Such depression may have a different aetiology to that in younger patients and be associated with comorbid chronic physical
Bhogle, Madhavi, Holland, Jonathon
core   +1 more source

Dibenzo[1,2,5]thiadiazepines are non-competitive GABAA receptor antagonists [PDF]

open access: yes, 2013
"A new process for obtaining dibenzo[c,f][1,2,5]thiadiazepines (DBTDs) and their effects on GABAA receptors of guinea pig myenteric neurons are described. Synthesis of DBTD derivatives began with two commercial aromatic compounds.
Carlos Barajas López   +8 more
core   +3 more sources

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