Results 51 to 60 of about 3,072 (115)

Use of Hemoadsorption and Continuous Venovenous Hemodialysis With Enhanced Middle Molecule Clearance in Drug‐Induced Rhabdomyolysis

open access: yesCase Reports in Critical Care, Volume 2025, Issue 1, 2025.
Drug‐induced rhabdomyolysis has become increasingly prevalent due to the rising use of medications such as statins, antidepressants, and antipsychotics. These can lead to muscle cell destruction and the release of myoglobin, potentially causing kidney damage.
Sebastian Hafner   +5 more
wiley   +1 more source

Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]

open access: yes, 2004
Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.
Baghai, Thomas C.   +2 more
core   +1 more source

Efficacy and safety of antidepressants for pain in older adults: A systematic review and meta‐analysis

open access: yesBritish Journal of Clinical Pharmacology, Volume 90, Issue 12, Page 3097-3118, December 2024.
Aims In many countries, pain is the most common indication for use of antidepressants in older adults. We reviewed the evidence from randomized controlled trials on the efficacy and safety of antidepressants, compared to all alternatives for pain in older adults (aged ≥65 years).
Sujita W. Narayan   +10 more
wiley   +1 more source

PET studies of the serotonin system in major depression and its treatment [PDF]

open access: yes, 2014
The serotonin system has been implicated in major depression since the 1960s, mainly based on the serotonin enhancing properties of antidepressants.
Tiger, Mikael
core   +1 more source

Ginsenoside Rg1: A Neuroprotective Natural Dammarane‐Type Triterpenoid Saponin With Anti‐Depressive Properties

open access: yesCNS Neuroscience &Therapeutics, Volume 30, Issue 12, December 2024.
Rg1 exhibits antidepressant effects through diverse mechanisms, such as anti‐inflammation, synaptic protection, neurogenesis promotion, brain‐derived neurotrophic factor release, enhancement of astrocyte gap junction function, and regulation of hypothalamic–pituitary–adrenal axis and antioxidative stress. Experimental studies validate Rg1's efficacy in
Dong Han   +5 more
wiley   +1 more source

Cognitive Remediation in Patients With Bipolar Disorder: A Randomized Trial by Sequential tDCS and Navigated rTMS Targeting the Primary Visual Cortex

open access: yesCNS Neuroscience &Therapeutics, Volume 30, Issue 12, December 2024.
All patients underwent a 3‐week intervention of combined electromagnetic stimulation. Scale assessments and magnetic resonance imaging data collection were performed before and after the intervention, followed by scale assessments at the eighth week.
Hetong Zhou   +11 more
wiley   +1 more source

A Phase 1 Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (2R,6R)‐Hydroxynorketamine in Healthy Volunteers

open access: yesClinical Pharmacology &Therapeutics, Volume 116, Issue 5, Page 1314-1324, November 2024.
(R,S)‐Ketamine (ketamine) is a dissociative anesthetic that also possesses analgesic and antidepressant activity. Undesirable dissociative side effects and misuse potential limit expanded use of ketamine in several mental health disorders despite promising clinical activity and intensifying medical need.
Shruti M. Raja   +40 more
wiley   +1 more source

Low‐dose amitriptyline: A potential therapeutic option for chronic pain in older people

open access: yes
British Journal of Clinical Pharmacology, Volume 91, Issue 3, Page 921-922, March 2025.
Takayuki Suga   +4 more
wiley   +1 more source

Multiple Acyl‐Coenzyme A Dehydrogenase Deficiency Is Associated with Sertraline Use – Is There an Acquired Form?

open access: yesAnnals of Neurology, Volume 96, Issue 4, Page 802-811, October 2024.
Objective Multiple acyl‐coenzyme A dehydrogenase deficiency (MADD) is a disorder of fatty acid oxidation and considered an inborn error of metabolism. In recent years, we have diagnosed an increasing number of patients where, despite extensive investigation, no disease‐causing mutations have been found. We therefore investigated a cohort of consecutive
Sofie Sunebo   +3 more
wiley   +1 more source

A target trial emulation comparing the antidepressant effectiveness of selective serotonin reuptake inhibitors (SSRIs) highlighting the importance of patent‐related confounding by indication

open access: yesActa Psychiatrica Scandinavica, Volume 150, Issue 4, Page 198-208, October 2024.
Abstract Background The comparative effectiveness of selective serotonin reuptake inhibitors (SSRIs) has been subjected to relatively little research. However, a recent study based on target trial emulation suggested that sertraline may be more effective than escitalopram.
Christopher Rohde   +2 more
wiley   +1 more source

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