Results 181 to 190 of about 3,411 (219)
Market Size in Innovation: Theory and Evidence from the Pharmaceutical Industry [PDF]
Daron Acemoglu, Joshua Linn
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Antidiarrheal Effects of Dihydroergotamine
The Journal of Clinical Pharmacology, 1977Dihydroergotamine (DHE), an alpha-adrenergic blocking agent, rapidly improved 121 out of 123 diarrheal patients. A hypotonic sigmoid and a hyperreactive rectum were found in these patients. Manometric studies of the distal colon showed that DHE counteracts the rectal hyperactivity and increases sigmoidal tone.
F, Lechin +3 more
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Digestive Diseases and Sciences, 1987
Successful treatment of severe diarrhea has traditionally relied upon opiates or opiate derivatives. Recent advances in our understanding of intestinal fluid and electrolyte absorption have provided the opportunity to develop therapeutic agents specific for various points in the secretory and absorptive process.
R N, Fedorak, M, Field
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Successful treatment of severe diarrhea has traditionally relied upon opiates or opiate derivatives. Recent advances in our understanding of intestinal fluid and electrolyte absorption have provided the opportunity to develop therapeutic agents specific for various points in the secretory and absorptive process.
R N, Fedorak, M, Field
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Current Gastroenterology Reports, 2017
Acute diarrhea often runs a self-limited course and little by way of treatment is needed except for oral rehydration therapy. Chronic diarrhea poses a longer-term problem. If not treatable with specific therapy aimed at the underlying pathophysiology, chronic diarrhea often needs long-term symptomatic therapy.This paper aims to examine the options for ...
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Acute diarrhea often runs a self-limited course and little by way of treatment is needed except for oral rehydration therapy. Chronic diarrhea poses a longer-term problem. If not treatable with specific therapy aimed at the underlying pathophysiology, chronic diarrhea often needs long-term symptomatic therapy.This paper aims to examine the options for ...
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Spinally mediated opioid antidiarrheal effects
European Journal of Pharmacology, 1991To assess the role of opioid receptors in the spinal cord in regulation of functions of the intestinal mucosa in a secretory model, we evaluated the ability of i.t. administered mu (PL017), delta (DPDPE) and kappa (U50,488H) selective opioid agonists to inhibit diarrhea produced in mice by an injection of prostaglandin E2 (PGE2) (200 micrograms/mouse ...
P K, Lemcke, J E, Shook, T F, Burks
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Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs.
The Journal of Pharmacology and Experimental Therapeutics, 1979Three synthetic antidiarrheals, diphenoxylate, loperamide and SC 27166, and two narcotics, morphine and codeine, were evaluated in rats by the intravenous and oral route for specificity and duration of their antidiarrheal, opiate-like and acute toxic effects.
C J, Niemegeers +3 more
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Metabolically Programmed Polyamine Analogue Antidiarrheals
Journal of Medicinal Chemistry, 1996The design, synthesis, and testing of a novel class of antidiarrheal drugs based on a tetraamine pharmacophore are reported. While N1,N14-diethylhomospermine (DEHSPM) (5 mg/kg) completely prevents diarrhea in rodents, tissue distribution studies demonstrated that the principal metabolite of DEHSPM, homospermine (HSPM), accumulates and persists in ...
R J, Bergeron +8 more
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Antimicrobial and Antidiarrheal drugs Survey
World Journal of Pharmaceutical Sciences, 2022Diarrhea is a major health problem throughout the world and it has become more problematic in developing countries like Ethiopia. People, in several parts of the world, use different traditional medicines for treating diarrhea and it has been reported that the roots, leaves, and flowers of various species are used for the same purpose.
Suthar Mona +3 more
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Nigerian Geophagical Clay: A Traditional Antidiarrheal Pharmaceutical
Science, 1985The chief geophagical clay entering the West African market system comes from the village of Uzalla, Nigeria. Village inhabitants ascribe antidiarrheal properties to the clay, and they use it in traditional medicinal preparations to counteract intestinal problems.
D E, Vermeer, R E, Ferrell
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