Results 51 to 60 of about 5,436 (148)

Aquaporin modulators: a patent review (2010-2015) [PDF]

, 2016
Introduction: Since the discovery of aquaporin-1 (AQP1) as a water channel, more than 2,000 articles, reviews and chapters have been published.
Casini, Angela, Soveral, Graça
core   +1 more source

New cases of δ‐aminolevulinic acid dehydratase deficiency: Functional insights into gene variants using an innovative mouse liver model

Journal of Internal Medicine, Volume 299, Issue 1, Page 126-142, January 2026.
Abstract Background Dysfunction of δ‐aminolevulinic acid dehydratase (ALAD), the second enzyme involved in heme biosynthesis, leads to two pathologies: genetic and acquired. The genetic form is an ultrarare, severe childhood‐onset disease inherited in an autosomal recessive manner, whereas the acquired form usually affects adults due to enzyme ...
Elena Di Pierro, Isabel Solares, Daniel Jericó, Francisco J. Castelbón, Javier Tomás Solera, Antoni Riera‐Mestre, María Barreda‐Sánchez, Carlo Poci, Annamaria Nicolli, Francesco Urigo, Ana Sampedro, Rafael Enríquez de Salamanca, Matteo Marcacci, Matías A. Ávila, Pauline Harper, Marta G. Fanlo‐Maresma, Encarna Guillén‐Navarro, Giovanna Graziadei, Andrea Wenzel, Bodo B. Beck, Paolo Ventura, Montserrat Morales‐Conejo, Antonio Fontanellas   +22 more
wiley   +1 more source

Clinical and molecular features of thiazide-induced hyponatremia [PDF]

, 2018
Hypertension affects more than 30% of the world’s adult population and thiazide (and thiazide-like) diuretics are amongst the most widely used, effective and least costly treatments available, with all-cause mortality benefits equivalent to ACE ...
Channavajjhala, Sarath K., Clayton, Jenny, Glover, Mark, Hall, Ian P., Jia, Wenjing, Nadal, Jodie   +5 more
core   +2 more sources

Model of Nocturnal Polyuria in Older Japanese Adults Receiving Enteral Nutrition in Medical Long‐Term Care Hospitals: An Exploratory Cross‐Sectional Study

LUTS: Lower Urinary Tract Symptoms, Volume 18, Issue 1, January 2026.
ABSTRACT Objective Nocturnal polyuria (NP) with urinary incontinence increases the risk of sleep disturbance, incontinence‐associated dermatitis, and urinary tract infection. Factors associated with NP in older adults receiving enteral nutrition (EN) have not been clearly identified.
Madoka Takimoto, Tamami Taniguchi
wiley   +1 more source

Short‐ and mid‐term effects of empagliflozin on sodium balance and fluid regulation in chronic heart failure

European Journal of Heart Failure, Volume 27, Issue 12, Page 3134-3141, December 2025.
Effects of empagliflozin on sodium and fluid regulation in chronic heart failure (CHF). EF, ejection fraction; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; NYHA, New York Heart Association. Aims Sodium–glucose co‐transporter 2 inhibitors have become a cornerstone in managing chronic heart failure (CHF).
Venera Bytyqi, Dennis Kannenkeril, Julie Kolwelter, Peter Linz, Agnes Bosch, Kristina Striepe, Marina V. Karg, Armin M. Nagel, Michael Uder, Mario Schiffer, Stephan Achenbach, Roland E. Schmieder   +11 more
wiley   +1 more source

Fármacos que atuam modulando a ação da vasopressina [PDF]

, 2015
Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências FarmacêuticasA vasopressina, também é designada por hormona antidiurética (ADH), a nível renal aumenta a
Cardoso, Ana Catarina Santos
core  

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, Volume 1, Issue 3, Page 322-358, December 2025.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats. [PDF]

, 2014
Beside its hormonal function in salt and water homeostasis, vasopressin released into distinct brain areas plays a crucial role in stress-related behavior resulting in the enhancement of an anxious/depressive-like state.
Anna Fodor, Barbara Klausz, Bibiána Török, Diána Balázsfi, Dóra Zelena, Krisztina B. Kovács, Mario Engelmann, Ottó Pintér   +7 more
core   +1 more source

Mechanisms of intrinsic osmolality and sodium detection by magnocellular neurosecretory neurons

Journal of Neuroendocrinology, Volume 37, Issue 12, December 2025.
Abstract The maintenance of extracellular fluid (ECF) osmolality and sodium concentration ([Na+]o) near optimal “set point” values sustains physiological functions and prevents pathological states such as hypo‐ and hypernatremia. The peptide hormones vasopressin (antidiuretic hormone) and oxytocin (a natriuretic hormone in rats) play key roles in this ...
Sandra Salgado‐Mozo, Anzala Murtaz, Joshua C. Wyrosdic, Julie O'Reilly‐Fong, Cristian Zaelzer, Mary P. LaPierre, Charles W. Bourque   +6 more
wiley   +1 more source

A randomised crossover trial of daridorexant for the treatment of chronic insomnia and nocturia

Journal of Sleep Research, Volume 34, Issue 6, December 2025.
Summary This double‐blind, placebo‐controlled, two‐way crossover trial evaluated the efficacy and safety of daridorexant in patients with chronic insomnia and comorbid nocturia. In total, 60 patients aged ≥55 years with insomnia complaints for ≥3 months, Insomnia Severity Index (ISI) ≥13 and ≥3 voids/night for ≥1 month were randomised (1:1) to ...
Katharina Lederer, Heike Benes, Alan Fine, Sylvia Shoffner, Sandro Bacchelli, David Castro Diaz, Jose Emilio Batista, Racheal Rowles, Tobias Di Marco, Michael Meinel   +9 more
wiley   +1 more source