Results 21 to 30 of about 30,443 (262)

Case Report: Serum methotrexate monitoring by immunoassay: confusion by by-product, confusion by antidote

Frontiers in Oncology, 2023
Methotrexate is a commonly used agent in the treatment of many malignancies and rheumatologic/inflammatory diseases. Working by inhibiting dihydrofolate reductase and thereby preventing eventual formation of tetrahydrofolate, methotrexate inhibits ...
Aditya Sharma, Philip Benoit, Frederick Lansigan, David Nierenberg   +3 more
doaj   +1 more source

Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral Snake) Venom

Toxins, 2018
There is a clear, unmet need for effective, lightweight, shelf-stable and economical snakebite envenoming therapies that can be given rapidly after the time of a snake’s bite and as adjuncts to antivenom therapies in the hospital setting. The sPLA2
Matthew R. Lewin, Lyndi L. Gilliam, John Gilliam, Stephen P. Samuel, Tommaso C. Bulfone, Philip E. Bickler, José María Gutiérrez   +6 more
doaj   +1 more source

Statutory, legal, scientific and productive aspects of conditions and prospects of development of antidote therapy in the Russian Federation

Вестник войск РХБ защиты, 2023
The modern period in the development of the world community and the Russian Federation in particular is characterized by the globalization of chemical danger.
V. D. Gladkikh, М. М. Muradov, N. А. Kolosova, I. К. Kasatkin, L. М. Slastilova   +4 more
doaj   +1 more source

Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high‐anticoagulant thrombin‐binding bivalent DNA aptamer‐linked M08 with HD22

Research and Practice in Thrombosis and Haemostasis, 2021
Background Bivalent thrombin‐binding aptamers (TBAs) have great potential for the treatment of thrombosis because they exhibit high anticoagulant activity, and their complementary single‐stranded DNA (ssDNA) sequences work as an antidote.
Toru Yoshitomi, Koji Wakui, Masato Miyakawa, Keitaro Yoshimoto   +3 more
doaj   +1 more source

Neutralizing Monoclonal Antibody, mAb 10D8, Is an Effective Detoxicant against Abrin-a Both In Vitro and In Vivo

Toxins, 2022
Abrin is a types II ribosome-inactivating protein (RIP) isolated from Abrus precatorious seeds, which comprises a catalytically active A chain and a lectin-like B chain linked by a disulfide bond.
Zhi Li, Hua Xu, Bo Ma, Li Luo, Lei Guo, Pingping Zhang, Yong Zhao, Lili Wang, Jianwei Xie   +8 more
doaj   +1 more source

Application of Activated Carbon Derived from Seed Shells of Jatropha curcas for Decontamination of Zearalenone Mycotoxin

Frontiers in Pharmacology, 2017
In the present study, activated carbon (AC) was derived from seed shells of Jatropha curcas and applied to decontaminate the zearalenone (ZEA) mycotoxin. The AC of J.
Naveen K. Kalagatur, Kumarvel Karthick, Joseph A. Allen, Oriparambil Sivaraman Nirmal Ghosh, Siddaiah Chandranayaka, Vijai K. Gupta, Kadirvelu Krishna, Venkataramana Mudili   +7 more
doaj   +1 more source

Pharmacologic and Clinical Considerations of Nalmefene, a Long Duration Opioid Antagonist, in Opioid Overdose

Psychiatry International, 2021
Opioid use disorder is a well-established and growing problem in the United States. It is responsible for both psychosocial and physical damage to the affected individuals with a significant mortality rate.
Amber N. Edinoff, Catherine A. Nix, Tanner D. Reed, Elizabeth M. Bozner, Mark R. Alvarez, Mitchell C. Fuller, Fatimah Anwar, Elyse M. Cornett, Adam M. Kaye, Alan D. Kaye   +9 more
doaj   +1 more source

Enzyme‐Inspired Hydrogen‐Bonded Organic Frameworks for Synergistic Capture, Detection, and Degradation of Nerve Agent Simulants

Advanced Science, EarlyView.
FDU‐HOF‐5, an enzyme‐inspired hydrogen‐bonded framework, enables targeted capture, real‐time visual alert, and detoxification of nerve agent simulants through biomimetic sites and multivalent interactions. Integrable into protective gear, it pioneers on‐site threat monitoring strategies for persistent neurotoxic hazards, advancing smart, responsive ...
Jiabao Liu, Guanglai Mo, Xiangyu Gao, Yingjia Deng, Yijin Wang, Qingyu Niu, Yujie Lei, Bin Fei, Joanne Yip, Zhaozhen Zhang, Jie Wu, Yunbo Bi, Kaikai Ma, Zhiqiang Li, Peng Li   +14 more
wiley   +1 more source

Preparation of Pectin Aerogels From Flaxseed and Evaluation of Their Potential as Hemostatic Agents: Water Absorption Characteristics

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Flaxseed has been used extensively to extract flaxseed oil and drugs used for breast cancer treatment. Flaxseed contains a considerable amount of pectin in addition. We extracted pectin from flaxseed and prepared pectin aerogels by the steps of de‐esterification, gelation, solvent exchange and supercritical CO2 drying.
Jin‐A Choe, Hyon‐Tae Pak, Kwang‐Myong Cha, Song‐Su Ma, Chol‐Ung Kim, Yong‐Son Rim   +5 more
wiley   +1 more source

Trends and variation in the use of andexanet alfa for the reversal of direct oral anticoagulants in NHS trusts in England

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Andexanet alfa was recommended by the National Institute for Health and Clinical Excellence (NICE) as an option in the management of life‐threatening gastrointestinal bleeding in patients taking apixaban or rivaroxaban in May 2021. A recent UK‐wide survey of local hospital protocols for the use of andexanet alfa suggested that practice ...
Louis Fisher, Richard Buka, Rosalind Byrne, Stephen Black, Helen J. Curtis, Christopher Wood, Andrew Brown, Sebastian Bacon, Richard Croker, Ben Goldacre, Brian MacKenna, Victoria Speed   +11 more
wiley   +1 more source