Results 91 to 100 of about 18,529 (289)

Switching From Standard to Extended Half‐Life Coagulation Factor Replacement in Haemophilia: Clinical Outcomes and Costs of Care in Finland

Haemophilia, EarlyView.
ABSTRACT Introduction Real‐world data are needed to evaluate treatment implementation, outcomes and costs of care in haemophilia patients switching prophylaxis from standard half‐life (SHL) to extended half‐life (EHL) clotting factor concentrates (CFCs).
Mirkka Koivusalo, Timea Szanto, Tuomas Kovalainen, Aino Vesikansa, Outi Laine, Anu Partanen, Timo Siitonen, Marko Vesanen, Juha Mehtälä, Nina Sarnesto, Johanna Haapkylä, Anna‐Elina Lehtinen, Riitta Lassila   +12 more
wiley   +1 more source

CM352 Reduces Brain Damage and Improves Functional Recovery in a Rat Model of Intracerebral Hemorrhage

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundIntracerebral hemorrhage (ICH) is an acute neurological disorder with high mortality and no effective treatment. In addition to the initial bleeding event, rebleeding and hematoma expansion are associated with poor outcome in these patients. We
José A. Rodríguez, Tomás Sobrino, Esteban López‐Arias, Ana Ugarte, Juan A. Sánchez‐Arias, Alba Vieites‐Prado, Irene de Miguel, Julen Oyarzabal, José A. Páramo, Francisco Campos, Josune Orbe, José Castillo   +11 more
doaj   +1 more source

Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): protocol and statistical analysis plan for a randomized controlled trial. [PDF]

, 2016
Background: Postpartum haemorrhage (PPH) is a leading cause of maternal death. Tranexamic acid has the potential to reduce bleeding and a large randomized controlled trial of its effect on maternal health outcomes in women with PPH (The WOMAN trial) is ...
Aimakhu, Chris O, Bello, Adenike, Fawole, Bukola, Gregg, Meghann, Huque, Sumaya, Kotila, Taiwo, Kuti, Modupe, Ogunbode, Olayinka, Olayemi, Oladapo, Roberts, Ian, Shakur, Haleema   +10 more
core   +2 more sources

Clotting Factor Concentration During Menstrual Phases in Women With and Without Heavy Menstrual Bleeding: A Systematic Review and Meta‐Analysis

Haemophilia, EarlyView.
ABSTRACT Background Cyclic sex‐hormone fluctuation impacts clotting factor concentrations, being lowest during the follicular phase of the menstrual cycle. This pattern is unexplored in women with heavy menstrual bleeding (HMB), but potentially affects the timely diagnosis of underlying bleeding disorders.
Anne de Vaan, Merel M. Goedkoop, Paco M. J. Welsing, Nehalennia van Hanegem, Roger E. G. Schutgens, Karin P. M. van Galen   +5 more
wiley   +1 more source

Antifibrinolytic drugs for acute traumatic injury.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2016
In South Africa, trauma is a major concern, with violence and road traffic accidents being the fifth and seventh leading causes of death, respectively. Antifibrinolytic agents have been used in trauma and major surgery to prevent fibrinolysis and reduce ...
M. McCaul, T. Kredo
semanticscholar   +1 more source

Traumatic injury clinical trial evaluating tranexamic acid in children (TIC-TOC): study protocol for a pilot randomized controlled trial. [PDF]

, 2018
BACKGROUND: Trauma is the leading cause of morbidity and mortality in children in the United States. The antifibrinolytic drug tranexamic acid (TXA) improves survival in adults with traumatic hemorrhage, however, the drug has not been evaluated in a ...
Adelson, P David, Barnhard, Sarah E, Bobinski, Matthew, Ghetti, Simona, Hewes, Hilary A, Holmes, James F, Kuppermann, Nathan, Michael Dean, J, Myers, Sage R, Nishijima, Daniel K, Roberts, Ian, Schalick, Walton O, Stanley, Rachel M, TIC-TOC Collaborators of the Pediatric Emergency Care Applied Re, Tran, Nam K, Tzimenatos, Leah S, VanBuren, John   +16 more
core   +2 more sources

ANTIFIBRINOLYTIC ACTIVITY IN NORMAL PREGNANCY [PDF]

Journal of Clinical Pathology, 1960
It is found that serum antifibrinolytic activity is inhibitory both to the spontaneous fibrinolytic activity and to the activity of streptokinase-activated plasminogen.The titres of serum antiplasmin activity during gestation, labour, and the puerperium are all of the same order and do not differ from those in non-pregnant women. The marked decrease in
openaire   +3 more sources

Antifibrinolytics for heavy menstrual bleeding [PDF]

Cochrane Database of Systematic Reviews, 2018
Heavy menstrual bleeding (HMB) is an important physical and social problem for women. Oral treatment for HMB includes antifibrinolytic drugs, which are designed to reduce bleeding by inhibiting clot-dissolving enzymes in the endometrium.Historically, there has been some concern that using the antifibrinolytic tranexamic acid (TXA) for HMB may increase ...
Bryant-Smith, Alison C, Lethaby, Anne, Farquhar, Cynthia, Hickey, Martha   +3 more
openaire   +4 more sources

The effect of tranexamic acid on the risk of death and hysterectomy in women with post-partum haemorrhage: statistical analysis plan for the WOMAN trial. [PDF]

, 2016
BACKGROUND: Severe haemorrhage is a leading cause of maternal death worldwide. Most haemorrhage deaths occur soon after childbirth. Severe post-partum bleeding is sometimes managed by the surgical removal of the uterus (hysterectomy).
Alfirevic, Zarko, Edwards, Philip, Elbourne, Diana, Roberts, Ian, Ronsmans, Carine, Shakur, Haleema   +5 more
core   +2 more sources

Bleeding Complications in JAK2‐Variant Essential Thrombocythemia: A Revisit in 2025

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterised by sustained thrombocytosis. Paradoxically, bleeding complications remain an under‐recognised clinical challenge. Compared with CALR‐mutated patients, those harbouring the JAK2‐V617F variant appear more prone to haemorrhage.
Gerard Gurumurthy, Samantha Gurumurthy, Tim C. P. Somervaille, Anna Falanga, Jecko Thachil   +4 more
wiley   +1 more source