Haemodilution-induced profibrinolytic state is mitigated by fresh-frozen plasma: implications for early haemostatic intervention in massive haemorrhage [PDF]
, 2017 Background Fibrinolysis contributes to coagulopathy after major trauma and surgery. We hypothesized that progressive haemodilution is responsible, at least in part, for increased fibrinolytic tendency of blood clot. Methods The study was performed in two
Bolliger, D. +4 more
core
Effect of oral tranexamic acid on macular edema associated with retinal vein occlusion or diabetes [PDF]
, 2017 Purpose: Tranexamic acid (TXA) is a widely used antifibrinolytic agent that can also cause a decrease in vascular permeability. We hypothesized that TXA could improve macular edema (ME) that is caused by an increase in retinal vascular permeability.
Gosho Masahiko +7 more
core +3 more sources
Postoperative bilateral visual loss after a single dose of tranexamic acid
Anaesthesia Reports, Volume 13, Issue 2, July‐December 2025.Summary A 32‐year‐old woman presented with transient visual loss following the intra‐operative administration of a single intravenous dose of tranexamic acid during urgent cholecystectomy. Apart from obesity, the patient had no notable medical history or pre‐existing ocular conditions.
B. Chevalley +4 more
wiley +1 more source
Cochrane Database of Systematic Reviews, 2015 BACKGROUND Minor oral surgery or dental extractions (oral or dental procedures) are widely performed and can be complicated by hazardous oral bleeding, especially in people with an inherited bleeding disorder such as haemophilia or Von Willebrand disease.
K. V. van Galen +4 more
semanticscholar +1 more source
On‐demand treatment of bleeds in haemophilia patients with inhibitors: strategies for securing and maintaining predictable efficacy with recombinant activated factor VII [PDF]
, 2011 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90042/1/j.1365-2516.2011.02612.x ...
Abshire +38 more
core +1 more source
Treatment Landscape in Pediatric Immune Thrombocytopenia: Addressing Unmet Needs
Pediatric Blood &Cancer, Volume 72, Issue 7, July 2025.ABSTRACT Pediatric immune thrombocytopenia (ITP) is associated with a multifaceted burden on children and their parents/caregivers due to bleeding, fatigue, activity restrictions, and psychological distress. Most children recover within 12 months, but up to 30% develop chronic ITP.
Joana Azevedo +4 more
wiley +1 more source
Cochrane Database of Systematic Reviews, 2015 BACKGROUND Upper gastrointestinal bleeding is one of the most frequent causes of morbidity and mortality in the course of liver cirrhosis. People with liver disease frequently have haemostatic abnormalities such as hyperfibrinolysis.
A. Marti-Carvajal, I. Solá
semanticscholar +1 more source
Anti-fibrinolytic agents in post partum haemorrhage: a systematic review
BMC Pregnancy and Childbirth, 2009 Background Post partum haemorrhage is a leading cause of maternal death worldwide. It also contributes to maternal morbidity as women may require a hysterectomy to control bleeding, or may require a blood transfusion, which can transmit viral infections.
Blackhall Karen +4 more
doaj +1 more source
Spontaneous gastrocnemius muscle haematoma formation in a patient with alcoholic liver disease
The Pan African Medical Journal, 2020 Advanced liver disease is associated with several haemostatic alterations which can lead to either thrombosis or bleeding complications. Spontaneous muscle haematomas although a rare complication of liver cirrhosis is increasingly being described in the ...
Ndawapeka Tulonga Nhinda +3 more
doaj +1 more source
Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components. [PDF]
, 2013 Background Proteases expressed in atherosclerotic plaque lesions generate collagen fragments, release glycosaminoglycans (chondroitin sulfate [CS] and dermatan sulfate [DS]) and expose extracellular matrix (ECM) proteins (e.g.
Bóta, Attila +7 more
core +1 more source