Results 91 to 100 of about 7,770 (215)

Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis

Journal of Lipid Research, 2019
It is postulated that lipoprotein (a) [Lp(a)] inhibits fibrinolysis, but this hypothesis has not been tested in humans due to the lack of specific Lp(a) lowering agents. Patients with elevated Lp(a) were randomized to antisense oligonucleotide [IONIS-APO(
Michael B. Boffa, Tanya T. Marar, Calvin Yeang, Nicholas J. Viney, Shuting Xia, Joseph L. Witztum, Marlys L. Koschinsky, Sotirios Tsimikas   +7 more
doaj   +1 more source

Bleeding related to disturbed fibrinolysis [PDF]

, 2016
The components and reactions of the fibrinolysis system are well understood. The pathway has fewer reactants and interactions than coagulation, but the generation of a complete quantitative model is complicated by the need to work at the solid‐liquid ...
Cawthern K.M., Colucci G., Dombret H., Goodpasture E.W., Janning M., Kashuk J.L., Kluft C., Lisman T., Longstaff C., Miura O., Oudijk E.J., Rick M.E., Rijken D.C.   +12 more
core   +1 more source

Progress on hematoma expansion mechanism and hemostatic therapy of spontaneous intracerebral hemorrhage

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Spontaneous intracerebral hemorrhage (SICH) is a severe subtype of stroke. Hematoma expansion could occur in the short term after symptom onset in most patients, leading to neurological deterioration and mortality.
LI Yu⁃jian, ZHENG Jun
doaj  

Antifibrinolíticos e cirurgia cardíaca com circulação extracorpórea Antifibrinolíticos y cirugía cardíaca con circulación extracorpórea Antifibrinolytics and cardiac surgery with cardiopulmonary bypass

Revista Brasileira de Anestesiologia, 2007
JUSTIFICATIVA E OBJETIVOS: A cirurgia cardíaca é a especialidade cirúrgica que com mais freqüência está associada a sangramento, coagulopatia e necessidade de derivados de sangue.
Ari-Tadeu Lírio dos Santos, João Carlos Splettstosser, Paulo Warpechowski, Mariana Mariz Pinto Gaidzinski   +3 more
doaj   +1 more source

Concomitant use of combined hormonal contraceptives and antifibrinolytic agents for the management of heavy menstrual bleeding: A practice pattern survey. [PDF]

Thromb Res, 2021
Lim MY, Olson L, Rajpurkar MA, Weyand AC.   +3 more
europepmc   +1 more source

Plasminflammation—An Emerging Pathway to Bradykinin Production

Frontiers in Immunology, 2019
Plasminogen activation is essential for fibrinolysis—the breakdown of fibrin polymers in blood clots. Besides this important function, plasminogen activation participates in a wide variety of inflammatory conditions. One of these conditions is hereditary
Coen Maas
doaj   +1 more source

Successful Management of Acute Catastrophic Juvenile Vaginal Bleeding in Glanzmann’s Thromboasthenia by Uterine Tamponade: A Case Report and Review of The Literature

Case Reports in Hematology, 2012
Glanzmann’s thromboasthenia (GT) is a rare platelet disorder, due to membrane defects involving glycoprotein GP IIb/IIIa complex. Symptoms appear in infancy with episodes of bruising, gingival bleeding, epistaxis, or at the time of menarche acute episode
Nazli Hossain, Tahir S. Shamsi, Adeel Feroz   +2 more
doaj   +1 more source

Concurrent Presentation of von Willebrand Disease and Inflammatory Bowel Disease—A Case Report and Literature Review

eJHaem, Volume 7, Issue 2, April 2026.
Suraj Pratap, Aimee Foord
wiley   +1 more source

Comparative study of topical vs. intravenous tranexamic acid regarding blood loss in total knee arthroplasty

Revista Brasileira de Ortopedia
Objective: To compare topical vs. intravenous tranexamic acid (TA) in total knee arthroplasty regarding blood loss and transfusion., Methods: Ninety patients were randomized to receive TA intravenously (20 mg/kg in 100 mL of saline; group IV ...
Ari Zekcer, Ricardo Del Priori, Clauber Tieppo, Ricardo Soares da Silva, Nilson Roberto Severino   +4 more
doaj   +1 more source

Peri- and Postpartum Management of Patients With Factor XI Deficiency

Clinical and Applied Thrombosis/Hemostasis, 2019
Factor XI (FXI) deficiency is an uncommon autosomal disorder with variable bleeding phenotype, making peripartum management challenging. We describe our experience in pregnant women with FXI deficiency and identify strategies to minimize the use of ...
Gloria F. Gerber MD, Kelsey A. Klute MD, John Chapin MD, James Bussel MD, Maria T. DeSancho MD, MSc   +4 more
doaj   +1 more source