Results 241 to 250 of about 326,437 (300)
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Applied Microbiology and Biotechnology, 2002
The search for new drugs against fungal infections is a major challenge to current research in mycotic diseases. The present article reviews the current types of antifungal infections, the current scenario of antifungal antibiotics, and the need and approaches to search for newer antifungal antibiotics and antifungal drug targets.
B N Ganguli
exaly +3 more sources
The search for new drugs against fungal infections is a major challenge to current research in mycotic diseases. The present article reviews the current types of antifungal infections, the current scenario of antifungal antibiotics, and the need and approaches to search for newer antifungal antibiotics and antifungal drug targets.
B N Ganguli
exaly +3 more sources
Current Opinion in Microbiology, 2022
Fungi have a profound impact on human health, leading to billions of infections and millions of deaths worldwide each year. Exacerbating the public health burden is the continued emergence of drug-resistant fungal pathogens coupled with a dearth of treatment options to combat serious infections.
Nicole, Robbins, Leah E, Cowen
openaire +2 more sources
Fungi have a profound impact on human health, leading to billions of infections and millions of deaths worldwide each year. Exacerbating the public health burden is the continued emergence of drug-resistant fungal pathogens coupled with a dearth of treatment options to combat serious infections.
Nicole, Robbins, Leah E, Cowen
openaire +2 more sources
Biochemical Pharmacology, 2017
The need for new antifungal agents is undeniable. Current therapeutic choices for the treatment of invasive fungal infections are limited to three classes of drugs. Most used antifungal agents are not completely effective due to the development of resistance, host toxicity and undesirable side effects that limit their use in medical practice.
Sonia, Campoy, José L, Adrio
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The need for new antifungal agents is undeniable. Current therapeutic choices for the treatment of invasive fungal infections are limited to three classes of drugs. Most used antifungal agents are not completely effective due to the development of resistance, host toxicity and undesirable side effects that limit their use in medical practice.
Sonia, Campoy, José L, Adrio
openaire +2 more sources
Medical Journal of Australia, 2007
The four main classes of antifungal drugs are the polyenes, azoles, allylamines and echinocandins. Clinically useful "older" agents include topical azole formulations (for superficial yeast and dermatophyte infections), first-generation triazoles (fluconazole and itraconazole, for a range of superficial and invasive fungal infections), amphotericin B ...
ARIKAN AKDAĞLI, SEVTAP, Rex, John H.
openaire +6 more sources
The four main classes of antifungal drugs are the polyenes, azoles, allylamines and echinocandins. Clinically useful "older" agents include topical azole formulations (for superficial yeast and dermatophyte infections), first-generation triazoles (fluconazole and itraconazole, for a range of superficial and invasive fungal infections), amphotericin B ...
ARIKAN AKDAĞLI, SEVTAP, Rex, John H.
openaire +6 more sources
Pediatric Clinics of North America, 1983
When the decision to treat a fungal infection is made, there are several antifungal agents available for use. AmB remains the first-line drug in the treatment of most systemic fungal infections. Miconazole should be used to treat patients who cannot tolerate AmB or who are infected with AmB-resistant organisms.
M H, Koldin, G, Medoff
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When the decision to treat a fungal infection is made, there are several antifungal agents available for use. AmB remains the first-line drug in the treatment of most systemic fungal infections. Miconazole should be used to treat patients who cannot tolerate AmB or who are infected with AmB-resistant organisms.
M H, Koldin, G, Medoff
openaire +2 more sources
Antifungals and antifungal drug discovery.
2012Abstract This chapter discusses: (1) important clinical aspects of invasive clinical mycoses, i.e., candidosis and aspergillosis; (2) current antifungal therapeutic options for invasive mycoses; (3) antifungal drug resistance; and (4) approaches to antifungal drug discovery, including identification of drug targets.
R. Calderone +6 more
openaire +1 more source
Steroids, 2003
Azasteroids and derivatives thereof with antifungal potential are reviewed. Special emphasis is put on steroids with nitrogen as part of the steroidal framework, natural substances, and lines of development emerging from them.
Joachim, Burbiel, Franz, Bracher
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Azasteroids and derivatives thereof with antifungal potential are reviewed. Special emphasis is put on steroids with nitrogen as part of the steroidal framework, natural substances, and lines of development emerging from them.
Joachim, Burbiel, Franz, Bracher
openaire +2 more sources
2005
The increase in fungal infections and the change in fungal epidemiology is caused by the extensive use of antifungal agents to treat fungal infections that are being diagnosed in severly immunocompromised hosts. In addition, opportunistic fungal infections resistant to antifungal drugs have become increasingly common, and the armamentarium for ...
Roxana G, Vitale +2 more
openaire +2 more sources
The increase in fungal infections and the change in fungal epidemiology is caused by the extensive use of antifungal agents to treat fungal infections that are being diagnosed in severly immunocompromised hosts. In addition, opportunistic fungal infections resistant to antifungal drugs have become increasingly common, and the armamentarium for ...
Roxana G, Vitale +2 more
openaire +2 more sources
2016
Determining the optimal polyene antifungal dosing in obese patients is considered highly challenging. Limited data are available to describe the pharmacokinetics of polyene antifungals in these patients. However, polyene antifungals demonstrate widely variable pharmacokinetics in various clinical conditions.
Jamal, Janattul-Ain, Roberts, Jason A.
openaire +3 more sources
Determining the optimal polyene antifungal dosing in obese patients is considered highly challenging. Limited data are available to describe the pharmacokinetics of polyene antifungals in these patients. However, polyene antifungals demonstrate widely variable pharmacokinetics in various clinical conditions.
Jamal, Janattul-Ain, Roberts, Jason A.
openaire +3 more sources
Current Opinion in Infectious Diseases, 2008
Invasive fungal infections remain a serious complication for critically ill ICU patients. The aim of this article is to review recent efficacy data of newer antifungal agents for the treatment of invasive candidiasis. The influence that recent epidemiological trends, advances in diagnostic testing, and risk prediction methods exert on the optimization ...
Playford, Elliott Geoffrey +2 more
openaire +5 more sources
Invasive fungal infections remain a serious complication for critically ill ICU patients. The aim of this article is to review recent efficacy data of newer antifungal agents for the treatment of invasive candidiasis. The influence that recent epidemiological trends, advances in diagnostic testing, and risk prediction methods exert on the optimization ...
Playford, Elliott Geoffrey +2 more
openaire +5 more sources