Results 101 to 110 of about 327,504 (360)

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

Synthesis and Antifungal Activity of Novel 3-Caren-5-One Oxime Esters

Molecules, 2017
A series of novel 3-caren-5-one oxime esters were designed and synthesized by multi-step reactions in an attempt to develop potent antifungal agents. Two E-Z stereoisomers of the intermediate 3-caren-5-one oxime were separated by column chromatography ...
Min Huang, Wen-Gui Duan, Gui-Shan Lin, Kun Li, Qiong Hu   +4 more
doaj   +1 more source

Optically active antifungal azoles. X. Synthesis and antifungal activity of N.

Chemical & pharmaceutical bulletin, 2001
New optically active antifungal azoles, N-14-(azolyl)phenyl]- and N-14-(azolylmethyl)phenyl]-N'-[(IR,2R)-2(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(IH-1,2,4-triazol-1-yl)propyllazolones (1, 2, 3), were prepared in a stereocontrolled manner. Compounds 1-3 showed strong antifungal activity against Candida albicans in vitro.
T, Kitazaki, T, Ichikawa, A, Tasaka, H, Hosono, Y, Matsushita, R, Hayashi, K, Okonogi, K, Itoh   +7 more
openaire   +2 more sources

APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis. [PDF]

, 2019
Invasive pulmonary aspergillosis (IPA) due to Aspergillus fumigatus is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high, and new treatments are needed ...
Alkhazraji, Sondus, Alqarihi, Abdullah, Gebremariam, Teclegiorgis, Gu, Yiyou, Ibrahim, Ashraf S, Jeon, Heewon H, Kapoor, Mili, Shaw, Karen J   +7 more
core  

The essential oil of Thymbra capitata and its application as a biocide on stone and derived surfaces [PDF]

, 2019
Many chemicals used nowadays for the preservation of cultural heritage pose a risk to both human health and the environment. Thus, it is desirable to find new and eco-friendly biocides that can replace the synthetic ones.
Bruno M., Gagliano Candela R., Lazzara G., Maggi F., Rosselli S.   +4 more
core   +1 more source

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Uji Aktifitas Antifungi Ekstrak Sarang Lebah Dari Luwu Utara Terhadap Candida albicans

Bioedukasi: Jurnal Pendidikan Biologi, 2017
Fungi infection is one of the main causes of health problems in Indonesia. One of them is caused by Candida albicans. To overcome infectious diseases can be done by looking for new alternatives with better antifungal activity.
Hartini Hartini
doaj   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Antifungal activity of guanidine compounds

Brazilian Journal of Microbiology
Guanidinic compounds are a class of compounds distributed in nature but also synthesized in vitro with a wide variety of applicability. One of the potentials of those molecules is antimicrobial activity. In that sense, although mainly limited to immunocompromised people, fungi pathogens are a cause of concern, even more so after the COVID-19 pandemic ...
Alexandra Daniela Barrios, Eguiluz, Caroline Barcelos Costa, Orlandi, Rafael Días, Do Espírito Santo, Eduardo Henrique, Zampieri, Luana Ribeiro, Dos Anjos, Maria José Soares Mendes, Giannini, Ana Marisa, Fusco-Almeida, Sandro Roberto, Valentini, Cleslei Fernando, Zanelli, Tatiana Maria, de Souza-Moreira, Eduardo René Pérez, González   +10 more
openaire   +2 more sources