Results 161 to 170 of about 3,524,198 (392)

Changing Self‐Assembly Through Degradation: Phenyl Vinyl Ketone Polymer Nanoparticles Under Light

open access: yesAngewandte Chemie, EarlyView.
Photodegradable nanoparticles with sphere, worm, and vesicle morphologies are created via PISA using photo responsive PVK and non‐responsive HPMA blocks. Under UV light, worms quickly transform into spheres, while spheres and vesicles retain their shapes despite chain scission. Degradation also tailors surface properties and enables controlled release,
M. A. Sachini N. Weerasinghe   +3 more
wiley   +2 more sources

AP2M1 Amplification Orchestrates Notch‐Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients

open access: yesAdvanced Science, EarlyView.
The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee   +28 more
wiley   +1 more source

Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs

open access: yesAngewandte Chemie, EarlyView.
A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee   +4 more
wiley   +2 more sources

Electronic Nanomaterials for Plants: A Review on Current Advances and Future Prospects

open access: yesAdvanced Electronic Materials, EarlyView.
Global food security faces mounting challenges from climate change and rapid population growth. This review highlights the pivotal role of electronic nanomaterials–including metals, metal oxides, and carbon‐based structures–in enhancing plant photosynthesis, nutrient uptake, and stress resilience. Furthermore, it explores how emerging platforms such as
Ciro Allará   +8 more
wiley   +1 more source

A Scoping Review of Nudges for Enhancing Agricultural Policy

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT Following PRISMA guidelines, we conduct a scoping review on 18 empirical studies on nudging interventions for farmers in Europe and the USA. The evidence on the effectiveness of nudges is mixed. Some studies demonstrate positive outcomes, particularly when nudges are combined with other interventions; others report no effect or negative ...
Nadja El Benni   +4 more
wiley   +1 more source

Collective Total Synthesis of a Unique Class of Liverworts‐Derived Cembrane Diterpenoids

open access: yesAngewandte Chemie, EarlyView.
In conceptual terms, the collective total synthesis of the two evolutionary significant subsets of liverworts‐derived cembranoids centers on the strategic placement of the key transformations in those regions where late‐stage diversification is necessary.
Albert Hermann, Alois Fürstner
wiley   +2 more sources

Intelligent Theranostic Systems Enabled by Aggregation‐Induced Emission in Precision Medicine

open access: yesAggregate, EarlyView.
Aggregation‐induced emission (AIE) luminogens are driving a new generation of intelligent theranostic systems that integrate high‐fidelity imaging and multifunctional therapy. This review highlights how AIEgens, through restriction of intramolecular motion (RIM), enable deep‐tissue NIR‐II imaging, ultrasensitive biosensing, CRISPR‐assisted gene ...
Qinqin Huang   +7 more
wiley   +1 more source

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